Core-Shell Magnetic Nanoparticles for Highly Sensitive Magnetoelastic Immunosensor

Campanile, Raffaele; Scardapane, Emanuela; Forente, A.; Granata, C.; Germano, Roberto; Girolamo, Rocco Di; Minopoli, Antonio; Velotta, R.; Ventura, Bartolomeo Della; Iannotti, V.

doi:10.3390/nano10081526

Cited by 14 publications

(8 citation statements)

References 53 publications

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“…Figure 2b,c showed the core-shell structure of the nanocomposites of Fe3O4/CS and Fe3O4/CS/PEI, respectively, that can be seen at the boundary of magnetite spherical NPs. This core-shell structure was reported in many previously synthesized magnetic nanomaterials [52][53][54]. Figure 2d showed the particle size distribution of the nanocomposite Fe3O4/CS/PEI that equals to 12 nm, similar to the results of XRD.…”

Section: The Characterization Of Synthesized Nanomaterialssupporting

confidence: 83%

“…Figure 2b,c showed the core-shell structure of the nanocomposites of Fe 3 O 4 /CS and Fe 3 O 4 /CS/PEI, respectively, that can be seen at the boundary of magnetite spherical NPs. This core-shell structure was reported in many previously synthesized magnetic nanomaterials [52][53][54]. Figure 2d According to Figure 3, all synthesized nanomaterials are ferromagnetic with saturation magnetization (Ms) of 71, 62, and 51 emu g −1 for Fe3O4, Fe3O4/CS, and Fe3O4/CS/PEI, respectively.…”

Section: The Characterization Of Synthesized Nanomaterialssupporting

confidence: 71%

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Polyethylenimine-Modified Magnetic Chitosan for the Uptake of Arsenic from Water

et al. 2021

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The removal of heavy metals from water has become a global environmental problem. Various materials have been applied as adsorbent to remove metals from water. In this field, nanomaterials have been gaining increasing interest due to their exceptional properties. In this work, we discuss the synthesis of a core-shell structure nanocomposite by the modification of magnetic chitosan (CS) (Fe3O4/CS) with polyethylenimine (PEI) to produce Fe3O4/CS/PEI composite for the adsorption of arsenic ions (As(V) and As(III)) from aqueous solution. The synthesized materials were characterized using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), transmission electron microscope (TEM), and vibrating sample magnetometer (VSM). The results indicated the successful combination of three components of the nanocomposite. The adsorption conditions were optimized by studying the effect of different parameters included pH, contact time, initial concentration, and adsorbent dosage. The optimum adsorption pH was found to be 6.7 while the optimum adsorbent dosage was found to be 2.0 and 1.5 g/L for As(III) and As(V), respectively. The removal efficiency for the uptake of As(III) and As(V) ions over Fe3O4/CS/PEI nanocomposite at optimum conditions was found to be 99.5 and 99.7%, respectively. The experimental results were fitted using Freundlich’s and Langmuir’s isotherms. The data were more fitted to Langmuir isotherm providing a suggestion of monolayer adsorption with maximum adsorption capacity equal to 77.61 and 86.50 mg/g for the removal of As(III) and As(V), respectively. Moreover, linear regression coefficient (R2) indicated that the adsorption of arsenic ions over the synthesized magnetic nanocomposite obeyed pseudo 2nd order suggesting the chemisorption process. The reusability of the nanosorbent for arsenic uptake using sodium hydroxide as eluent was also assessed up to five cycles. Interestingly, Fe3O4/CS/PEI nanocomposite can be considered as a promising adsorbent for As ions’ removal from water and should be tested for the removal of other pollutants.

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Section: The Characterization Of Synthesized Nanomaterialssupporting

confidence: 83%

“…Figure 2b,c showed the core-shell structure of the nanocomposites of Fe 3 O 4 /CS and Fe 3 O 4 /CS/PEI, respectively, that can be seen at the boundary of magnetite spherical NPs. This core-shell structure was reported in many previously synthesized magnetic nanomaterials [52][53][54]. Figure 2d According to Figure 3, all synthesized nanomaterials are ferromagnetic with saturation magnetization (Ms) of 71, 62, and 51 emu g −1 for Fe3O4, Fe3O4/CS, and Fe3O4/CS/PEI, respectively.…”

Section: The Characterization Of Synthesized Nanomaterialssupporting

confidence: 71%

Polyethylenimine-Modified Magnetic Chitosan for the Uptake of Arsenic from Water

et al. 2021

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“…Recently, attentions have been increased toward the improvement and application of magnetic nanoparticles in biosensors due to their properties like easy synthesis, biocompatibility with biomolecules, provide immobilization substrates for bio-recognition residues (peptides, aptamers, and antibodies), exceptional physicochemical properties, high mass transference, high surface area [ 83 ]. The simple synthesis, modification, and functionalization of magnetic nanoparticles were presented in Figure 5 .…”

Section: Antibiotics Electrochemical Detection Methodsmentioning

confidence: 99%

The Application of Nanomaterials for the Electrochemical Detection of Antibiotics: A Review

et al. 2021

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Antibiotics can accumulate through food metabolism in the human body which may have a significant effect on human safety and health. It is therefore highly beneficial to establish easy and sensitive approaches for rapid assessment of antibiotic amounts. In the development of next-generation biosensors, nanomaterials (NMs) with outstanding thermal, mechanical, optical, and electrical properties have been identified as one of the most hopeful materials for opening new gates. This study discusses the latest developments in the identification of antibiotics by nanomaterial-constructed biosensors. The construction of biosensors for electrochemical signal-transducing mechanisms has been utilized in various types of nanomaterials, including quantum dots (QDs), metal-organic frameworks (MOFs), magnetic nanoparticles (NPs), metal nanomaterials, and carbon nanomaterials. To provide an outline for future study directions, the existing problems and future opportunities in this area are also included. The current review, therefore, summarizes an in-depth assessment of the nanostructured electrochemical sensing method for residues of antibiotics in different systems.

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“…Magnetic field hyperthermia offers a promising approach to support cancer therapies in which the MNPs are locally heated by a time-varying magnetic field [ 3 ]. Furthermore, magnetoelastic biosensors in combination with magnetic nanoparticles offer an approach for the wireless detection of pathogens in liquids and for real-life diagnostic purposes [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

MNP-Enhanced Microwave Medical Imaging by Means of Pseudo-Noise Sensing

Ley

Sachs

Faenger

et al. 2021

Sensors

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Magnetic nanoparticles have been investigated for microwave imaging over the last decade. The use of functionalized magnetic nanoparticles, which are able to accumulate selectively within tumorous tissue, can increase the diagnostic reliability. This paper deals with the detecting and imaging of magnetic nanoparticles by means of ultra-wideband microwave sensing via pseudo-noise technology. The investigations were based on phantom measurements. In the first experiment, we analyzed the detectability of magnetic nanoparticles depending on the magnetic field intensity of the polarizing magnetic field, as well as the viscosity of the target and the surrounding medium in which the particles were embedded, respectively. The results show a nonlinear behavior of the magnetic nanoparticle response depending on the magnetic field intensity for magnetic nanoparticles diluted in distilled water and for magnetic nanoparticles embedded in a solid medium. Furthermore, the maximum amplitude of the magnetic nanoparticles responses varies for the different surrounding materials of the magnetic nanoparticles. In the second experiment, we investigated the influence of the target position on the three-dimensional imaging of the magnetic nanoparticles in a realistic measurement setup for breast cancer imaging. The results show that the magnetic nanoparticles can be detected successfully. However, the intensity of the particles in the image depends on its position due to the path-dependent attenuation, the inhomogeneous microwave illumination of the breast, and the inhomogeneity of the magnetic field. Regarding the last point, we present an approach to compensate for the inhomogeneity of the magnetic field by computing a position-dependent correction factor based on the measured magnetic field intensity and the magnetic susceptibility of the magnetic particles. Moreover, the results indicate an influence of the polarizing magnetic field on the measured ultra-wideband signals even without magnetic nanoparticles. Such a disturbing influence of the polarizing magnetic field on the measurements should be reduced for a robust magnetic nanoparticles detection. Therefore, we analyzed the two-state (ON/OFF) and the sinusoidal modulation of the external magnetic field concerning the detectability of the magnetic nanoparticles with respect to these spurious effects, as well as their practical application.

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Core-Shell Magnetic Nanoparticles for Highly Sensitive Magnetoelastic Immunosensor

Cited by 14 publications

References 53 publications

Polyethylenimine-Modified Magnetic Chitosan for the Uptake of Arsenic from Water

Polyethylenimine-Modified Magnetic Chitosan for the Uptake of Arsenic from Water

The Application of Nanomaterials for the Electrochemical Detection of Antibiotics: A Review

MNP-Enhanced Microwave Medical Imaging by Means of Pseudo-Noise Sensing

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