Core/shell upconversion nanoparticles with intense fluorescence for detecting doxorubicin <i>in vivo</i>

Hu, Junshan; Zhan, Shiping; Wu, Xiaofeng; Hu, Shigang; Wu, Shihong; Liu, Yunxin

doi:10.1039/c8ra02928h

Cited by 29 publications

(15 citation statements)

References 42 publications

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“…Finally, the UCNPs@NRs sample was tested. By the spectrum coincidence between the neutral red absorption and UCNPs green emission, the FRET effect resulted from the band match between the two aptamers leading to fluorescence quenching of core/shell UCNPs, but 655 nm emission intensity was not sensitive to the neutral red.…”

Section: Methodsmentioning

confidence: 99%

“…After 20 min, the reaction was sufficiently stirred, the mixture was adjusted to pH 6.0 with HCl (1 m ). By the absorption of neutral red and the emission of core/shell UCNPs, it was easily inferred that 535 nm green emission (GE) of CS UCNPs could be quenched by neutral red. Nitrite could react with neutral red specifically to generate diazonium salt and lose the functional group of diazonium, which leads to the remarkable decrease in NR.…”

Section: Methodsmentioning

confidence: 99%

“…The photos of Chinese cabbage cell was obtained by a Samsung digital camera (NX2000). Excited by 980 nm laser, the upconversion luminescent spectra were obtained by a fluorescence spectrometer equipment (Hitachi F‐2700) …”

Section: Characterizationmentioning

confidence: 99%

“…The unique optical properties of upconversion nanoparticles (UCNP) attracted much attention, which could convert low‐energy photons into high‐energy photons . Because of sharp emission, low injury penetrates the skin and zero self‐background fluorescence multicolor imaging, upconversion nanoparticles are expected to quickly move into clinical practice to solve many disease problems Here, we demonstrate a NR‐modified core/shell UCNPs probe for efficient detection of nitrite in plant cells with a test limit of 0.1 µg mL −1 .…”

Section: Introductionmentioning

confidence: 99%

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Dye‐Sensitized Core/Shell Upconversion Nanoparticles for Detecting Nitrites in Plant Cells

Zhan

et al. 2019

Part & Part Syst Charact

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A fluorescent nanoprobe is reported for rapid detection of nitrites (NO2−) in plant cells. The probe is fabricated by linking neutral reds (NR) to the surface of upconversion fluorescent core/shell nanocrystalline with the bridging of polyethylene glycol (PEG) molecules. The fluorescence of upconversion nanoparticles (UCNPs) is stored by NR through fluorescence resonance energy transfer (FRET) under 980 nm excitation that can be released by further linking to NO2−. It is observed that the intensity rate of green to red emission of NR‐modified UCNPs changes linearly with increasing the amount of NO2−. So that concentration of NO2− can be accordingly addressed. Worth mentioning is that, comparing with bare core upconversion nanoparticles (NPs), core/shell UCNPs can greatly reduce the surface quenching of the fluorescence induced by solvents instead of NR and thus leading to the enhancement of signal‐to‐noise ratios. Moreover, excitation of core/shell UCNPs requires only a much lower power (0.06 W cm−2) than bare cores which is beneficial to reducing the decomposition of NR to stabilize the FRET processes. Under the optimum conditions, the detection limit of nitrite in plant cells was 0.1 µg mL−1.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dye‐Sensitized Core/Shell Upconversion Nanoparticles for Detecting Nitrites in Plant Cells

Zhan

et al. 2019

Part & Part Syst Charact

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“…To obtain PABA‐supported core/inert–shell UCNPs, NaGdF 4 :Yb 3+ ,Er 3+ core and NaYF 4 @NaGdF 4 :Yb 3+ ,Er 3+ core/shell (CS) UCNPs with uniform particle size were first synthesized by the method in our previous works, with average diameter of 28 and 34 nm, and shown in Figure a,b, respectively. A uniform shell thickness of 3 nm was clearly observed.…”

Section: Structurementioning

confidence: 99%

Steady State Luminescence Enhancement in Plasmon Coupled Core/Shell Upconversion Nanoparticles

Zhan

Xiong

Nie

et al. 2019

Adv Materials Inter

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Plasmon enhanced upconversion luminescence has been deeply investigated and finds extensive applications from fluorescent sensors to cancer therapy. Here, the steady state luminescence enhancement is shown in plasmonic substrate coupled upconversion nanoparticles (UCNPs). The plasmonic Au‐nanohole‐nanoplate bilayer arrays (PABAs) are designed for generating full‐covered local field which couple both the excitation and the emission field of core/shell UCNPs. By tuning the coupling distance through a 3 nm thick inert shielding shell on upconversion nanoparticles, the plasmon enhanced upconversion luminescence enhancement is found independent on excitation power. This effect will greatly facilitate the applications of plasmon enhanced upconversion nanoparticles as biosensors even under extremely weak excitation. E.g., PABA‐supported core/inert–shell UCNPs are employed as a fluorescent sensor for detecting acetic acid gas, and a linear relationship between upconversion luminescent intensity and acetic acid concentration can be obtained as expected, accompanied by a detection limit of 81 nmol mL−1, which is one order of magnitude lower than the best level ever reported.

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Frequency Upconversion in UCNPs Containing Rare‐Earth Ions

Pattnaik

Kumar

2022

Upconverting Nanoparticles

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Core/shell upconversion nanoparticles with intense fluorescence for detecting doxorubicin in vivo

Abstract: This proposed UCNP probe design and results may provide some guidance for the real-time and efficient detection of Dox, and can be helpful in biomedical applications.

Cited by 29 publications

References 42 publications

Dye‐Sensitized Core/Shell Upconversion Nanoparticles for Detecting Nitrites in Plant Cells

Dye‐Sensitized Core/Shell Upconversion Nanoparticles for Detecting Nitrites in Plant Cells

Steady State Luminescence Enhancement in Plasmon Coupled Core/Shell Upconversion Nanoparticles

Frequency Upconversion in UCNPs Containing Rare‐Earth Ions

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