Corn-like Au/Ag nanorod-mediated NIR-II photothermal/photodynamic therapy potentiates immune checkpoint antibody efficacy by reprogramming the cold tumor microenvironment

Jin, Liangjie; Shen, Song; Huang, Youju; Li, Dongdong; Yang, Xianzhu

doi:10.1016/j.biomaterials.2020.120582

Cited by 83 publications

(60 citation statements)

References 44 publications

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“…The blackbody property enabled AuPB with good photothermal properties and was a promising photothermal agent. In addition, Jin et al (2021) prepared corn-like Au/Ag NRs, also showed good therapeutic effect for breast cancer treatment in mice.…”

Section: Photothermal Treatmentmentioning

confidence: 99%

Recent Progress on NIR-II Photothermal Therapy

Zhang

et al. 2021

Front. Chem.

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Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials in near-infrared region (NIR-I, 750-900 nm) attracts extensive attention in recent years because of the good biological penetration of NIR light. However, the penetration depth is still not enough for solid tumors due to high tissue scattering. The light in the second near-infrared region (NIR-II, 1000-1700 nm) allows deeper tissue penetration, higher upper limit of radiation and greater tissue tolerance than that in the NIR-I, and it shows greater application potential in photothermal conversion. This review summarizes the photothermal properties of Au nanomaterials, two-dimensional materials, metal oxide sulfides and polymers in the NIR-II and their application prospects in photothermal therapy. It will arouse the interest of scientists in the field of cancer treatment as well as nanomedicine.

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Section: Photothermal Treatmentmentioning

confidence: 99%

Recent Progress on NIR-II Photothermal Therapy

Zhang

et al. 2021

Front. Chem.

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“…ANP was combined with HSP-Cas9 for PD-L1 genome editing to enhance the antitumor immune response by inhibiting T-cell silencing via the PD-1/PD-L1 checkpoint pathway. Similarly, the bimetallic Au/Ag nanoparticles irradiated with NIR-II laser can reprogram cold TME to hot TME via PTT and PDT [15]. The combination of PTT and PDT induces ICD in tumors, APC activation, and DC maturation, thereby resulting in the infiltration of T cells in the TME and the reprogramming of cold tumors into hot tumor TM [15].…”

Section: Metallic Nanoparticle-mediated Dendritic Cell Maturationmentioning

confidence: 99%

“…The optical properties of MNPs can be used to intensify in vivo tracking using multiple imaging modalities, such as computed tomography (CT) [8], magnetic resonance imaging (MRI) [9], positron emission tomography (PET) [10], photoacoustic imaging (PA) [11], ultrasound (US) [12] and surface-enhanced Raman scattering (SERS) [13]. Although MNPs are wellknown drug carriers, they are also currently being investigated as potential candidates for photothermal therapy (PTT) [14], photodynamic therapy (PDT) [15], sonodynamic therapy (SDT) [16], chemodynamic therapy (CDT) [17], magnetic hyperthermia therapy (MHT) [18], and immune therapy (IT) [19]. MNPs, such as gold nanoparticles (GNPs) [20], copper nanoparticles (CuNPs) [21], and molybdenum oxide nanoparticles [22], exhibit localized surface plasmon resonance and generate local heat upon near-infrared (NIR) laser irradiation.…”

Section: Introductionmentioning

confidence: 99%

Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy

2021

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Cancer immunotherapy strategies leveraging the body’s own immune system against cancer cells have gained significant attention due to their remarkable therapeutic efficacy. Several immune therapies have been approved for clinical use while expanding the modalities of cancer therapy. However, they are still not effective in a broad range of cancer patients because of the typical immunosuppressive microenvironment and limited antitumor immunity achieved with the current treatment. Novel approaches, such as nanoparticle-mediated cancer immunotherapies, are being developed to overcome these challenges. Various types of nanoparticles, including liposomal, polymeric, and metallic nanoparticles, are reported for the development of effective cancer therapeutics. Metallic nanoparticles (MNPs) are one of the promising candidates for anticancer therapy due to their unique theranostic properties and are thus explored as both imaging and therapeutic agents. In addition, MNPs offer a dense surface functionalization to target tumor tissue and deliver genetic, therapeutic, and immunomodulatory agents. Furthermore, MNPs interact with the tumor microenvironment (TME) and regulate the levels of tumor hypoxia, glutathione (GSH), and reactive oxygen species (ROS) for remodulation of TME for successful therapy. In this review, we discuss the role of nanoparticles in tumor microenvironment modulation and anticancer therapy. In particular, we evaluated the response of MNP-mediated immune cells, such as dendritic cells, macrophages, T cells and NK cells, against tumor cells and analyzed the role of MNP-based cancer therapies in regulating the immunosuppressive environment.

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“…Tumor cells undergoing ICD can evoke danger-associated molecular patterns (DAMPs) to recruit intratumoral T lymphocytes infiltration as well as an increased ratio of cytotoxic T lymphocytes (CTLs), resulting in the enhanced immune response [ 13 – 15 ]. Therefore, the development of agents with simultaneous PDT and PTT effects is advantageous to trigger significant ICD with better therapeutic efficacy [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Dye-loaded mesoporous polydopamine nanoparticles for multimodal tumor theranostics with enhanced immunogenic cell death

et al. 2021

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Background Tumor phototherapy especially photodynamic therapy (PDT) or photothermal therapy (PTT), has been considered as an attractive strategy to elicit significant immunogenic cell death (ICD) at an optimal tumor retention of PDT/PTT agents. Heptamethine cyanine dye (IR-780), a promising PDT/PTT agent, which can be used for near-infrared (NIR) fluorescence/photoacoustic (PA) imaging guided tumor phototherapy, however, the strong hydrophobicity, short circulation time, and potential toxicity in vivo hinder its biomedical applications. To address this challenge, we developed mesoporous polydopamine nanoparticles (MPDA) with excellent biocompatibility, PTT efficacy, and PA imaging ability, facilitating an efficient loading and protection of hydrophobic IR-780. Results The IR-780 loaded MPDA (IR-780@MPDA) exhibited high loading capacity of IR-780 (49.7 wt%), good physiological solubility and stability, and reduced toxicity. In vivo NIR fluorescence and PA imaging revealed high tumor accumulation of IR-780@MPDA. Furthermore, the combined PDT/PTT of IR-780@MPDA could induce ICD, triggered immunotherapeutic response to breast tumor by the activation of cytotoxic T cells, resulting in significant suppression of tumor growth in vivo. Conclusion This study demonstrated that the as-developed compact and biocompatible platform could induce combined PDT/PTT and accelerate immune activation via excellent tumor accumulation ability, offering multimodal tumor theranostics with negligible systemic toxicity. Graphical Abstract

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Corn-like Au/Ag nanorod-mediated NIR-II photothermal/photodynamic therapy potentiates immune checkpoint antibody efficacy by reprogramming the cold tumor microenvironment

Cited by 83 publications

References 44 publications

Recent Progress on NIR-II Photothermal Therapy

Recent Progress on NIR-II Photothermal Therapy

Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy

Dye-loaded mesoporous polydopamine nanoparticles for multimodal tumor theranostics with enhanced immunogenic cell death

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