Corneal Absorption of Fluorometholone in Rabbits

Sieg, James W.; Robinson, Joseph R.

doi:10.1001/archopht.1974.01010010248016

Cited by 17 publications

(8 citation statements)

References 9 publications

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“…Considerably larger values are found in the stimulated eye (SIEG and ROBINSON 1977) or on deviations from physiological pH (CONRAD et al 1978), but the flow returns to baseline after topical anesthesia (PATTON and ROBINSON 1975). The position of the animal's head, when it is under anesthesia, has a noticeable effect on drainage (SIEG and ROBINSON 1974).…”

Section: A} Tearsmentioning

confidence: 99%

Ocular Pharmacokinetics

Maurice¹,

Mishima²

1984

Handbook of Experimental Pharmacology

224

169

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Section: A} Tearsmentioning

confidence: 99%

Ocular Pharmacokinetics

Maurice¹,

Mishima²

1984

Handbook of Experimental Pharmacology

224

169

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“…Neither approach has been previously explored, but the use of drugs to decrease or inhibit selectively tear turnover andlor solution drainage to improve drug bioavailability seems particularly attractive. It has been shown (7) that rabbits under systemic anesthesia, whose tear production is inhibited (1, 8), achieve significantly higher aqueous humor levels of an instilled drug.…”

mentioning

confidence: 99%

Influence of Topical Anesthesia on Tear Dynamics and Ocular Drug Bioavailability in Albino Rabbits

Patton

Robinson

1975

Journal of Pharmaceutical Sciences

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“…Systemic anesthesia increases the bioavailabi 1 ity of a topically applied drug by reducing the turnover of tears, the blinking rate, and eye movements (5,23). During ketamine anesthesia, corneal reflexes are maintained (15).…”

Section: Discussionmentioning

confidence: 99%

“…It was previously demonstrated that barbiturate anesthesia greatly affects the aqueous humor drug level time profile of a topically-applied compound (5). The comparable effects of ketamine have not been published.…”

Section: Introductionmentioning

confidence: 99%

On the Use of Ketamine in Ocular Pharmacological Studies

Bar-Ilan¹,

Pessah²

1986

Journal of Ocular Pharmacology and Therapeutics

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The effects of ketamine anesthesia in ocular pharmacological studies were investigated in albino rabbits over a period of 6 hr. Ketamine injection (30 or 90 mg/kg, i.m.) was accompanied by a 6 mm Hg elevation of intraocular pressure (IOP), lasting for 2 -4 hr. Body temperature (T^) showed an initial significant increase followed by a decrease, with changes ranging between +1.6 to -1.2°C.Aqueous humor levels of ethoxzolamide following topical application of a 2% suspension were 2-9 times higher in ketamine-treated rabbits. The observed elimination rate constant for ethoxzolamide was A = -0.34 hr"1 in ketamine-treated rabbits, half of that observed in normal rabbits (A = -0.73 hr"1).In spite of the higher ethoxzolamide levels in aqueous humor, the measured ocular hypotensive response to ethoxzolamide was greatly reduced by ketamine treatment. These findings demonstrate that great care should be taken in interpretation and comparison of ocular pharmacological data obtained in ketamine-anesthetized rabbits.

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Corneal Absorption of Fluorometholone in Rabbits

Cited by 17 publications

References 9 publications

Ocular Pharmacokinetics

Ocular Pharmacokinetics

Influence of Topical Anesthesia on Tear Dynamics and Ocular Drug Bioavailability in Albino Rabbits

On the Use of Ketamine in Ocular Pharmacological Studies

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