1987
DOI: 10.1136/bjo.71.8.598
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Corneal and intraocular penetration of topical and subconjunctival fusidic acid.

Abstract: SUMMARY Corneal tissue absorption and intraocular penetration of fusidic acid were assessed in the rabbit after topical or subconjunctival application. Corneal tissue levels of fusidic acid one hour after the last topical application of the drug were well above the minimum inhibitory concentrations (MICs) for most Gram-positive and many Gram-negative organisms. Adequate levels were achieved in the aqueous at one hour following the last topical application, but no significant levels were detected in the vitreou… Show more

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Cited by 17 publications
(10 citation statements)
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“…Although good corneal penetration and absence of known topical toxicity make fusidic acid suitable for the treatment of microbial keratitis, it is not recommended for endophthalmitis due to nonadequate levels in the vitreous following topical application [8]. However, ofloxacin was promising with a 79.5% susceptible rate in Gram-positive isolates.…”
Section: Discussionmentioning
confidence: 99%
“…Although good corneal penetration and absence of known topical toxicity make fusidic acid suitable for the treatment of microbial keratitis, it is not recommended for endophthalmitis due to nonadequate levels in the vitreous following topical application [8]. However, ofloxacin was promising with a 79.5% susceptible rate in Gram-positive isolates.…”
Section: Discussionmentioning
confidence: 99%
“…, 1987b). For some related studies, these have been specified as Sarcina lutea ATCC 9341 or Corynebacterium xerosis FF (Taylor et al. , 1987; Thorn and Johansen, 1997).…”
Section: The In Vitro Efficacy Of Fusidic Acid As An Antibacterial Drugmentioning
confidence: 99%
“…Hence, for example, MICs for Staph. epidermidis have been reported to be between 0.12 and 0.15 μ g mL −1 (Taylor et al. , 1987; Jackson et al.…”
Section: The In Vitro Efficacy Of Fusidic Acid As An Antibacterial Drugmentioning
confidence: 99%
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“…The first step in validating this route was to determine the well-tolerated dose, which varies according to the physicochemical properties of a drug. For example, a subconjunctival injection of 100 mg of ceftazidime induces only mild local irritation at the site of injection in rabbits (16), whereas injection of 100 mg of fusidic acid induces severe conjunctival necrosis and corneal edema (17). The well-tolerated dose of subconjunctival pefloxacin was 0.8 mg on the basis of clinical and histopathological criteria.…”
Section: Discussionmentioning
confidence: 99%