Corneal and Tear Film Changes After Botulinum Toxin-A in Blepharospasm or Hemifacial Spasm

Abstract

BTX-A injection therapy was affected the tear film in patients with blepharospasm or hemifacial spasm. However, there were no changes in corneal parameters, except corneal astigmatism, in these patients after treatment.

Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm

“…and Kocabeyoglu et al . found that TBUT was significantly higher at 3 weeks after injection 37 , 41 . We focused on the tear film LLT, which can reflect the tear film stability in an alternative manner and directly reveal meibomian gland function 42 , and found that BoNT injection significantly increased the tear film LLT without affecting meibomian gland dropout (Table 2 ).…”

Differences in Corneal Parameters Between Affected and Normal Contralateral Eyes in Patients With Hemifacial Spasm Treated With Botulinum Toxin-A

“…Moon et al 22 observed reduction in astigmatism values in patients with HFS 1 month after treatment with BTX-A. Gunes et al 23 used Scheimpflug imaging to evaluate corneal parameters in patients with HFS before BTX-A application and with 3-week and 3-month follow-ups. They observed significant reduction in astigmatism values three weeks and three months after treatment; nevertheless, changes in other corneal parameters were not observed.…”

Impact of botulinum toxin-A on corneal curvature assessed with Scheimpflug and Placido systems

“…Using videokeratoscopy, Moon et al 26 observed a reduction in astigmatism values in these patients 1 month after treatment with BTX-A. Gunes et al 27 used the Scheimpflug system to assess corneal parameters in hemifacial spasm patients before BTX-A application and at the 3-week and 3-month follow-ups. They found a significant reduction in astigmatism at both timepoints; nevertheless, significant changes in other corneal parameters were not observed.…”