Corneal antinociceptive effect of (-)-α-bisabolol

Abstract

Context: (-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area.Objective: To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent.Materials and methods: Acute corneal nociception was induced by the local application of hypertonic saline (5 M NaCl; 20 μL) to the corneal surface of Swiss mice (n = 8/group) 60 min after topical treatment with solutions or ointment containing BISA (50–200 mg/mL). The number of eye wipes performed with the ipsilateral forepaw was counted for a period of 30 s. Control groups (vehicles) were included.Results: BISA (50, 100 or 200 mg/mL) solubilized with Tween 80 did not reduce the number of eye wipes. Animals treated with the ointment (BISA 50, 100 or 200 mg/mL; p < 0.001), as well the solution containing propylene glycol (BISA 100 mg/mL; p < 0.05), showed significant reduction in the number of nociceptive behaviours. Solutions containing propylene glycol and isopropyl myristate had no effects.Discussion and conclusion: BISA possess corneal antinociceptive activity. Although the ointment presented antinociceptive effect, it is concluded that BISA when associated with propylene glycol has better potential for corneal nociceptive pain since it is more comfortable to use, leading to greater acceptance by patients.

α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson’s Disease

“…BSB was diluted in oil to prepare the dose of 50 mg/kg body weight. BSB dose in the present study was selected based on previous studies [ 31 ] and was injected intraperitoneally 30 min before ROT administration, once daily for 4 weeks. Administration of oil alone (vehicle) to the animals served as control.…”

Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

“…In test models of visceral pain induced by cyclophosphamide and mustard oil, α-Bisabolol was evaluated and showed an ability to reduce pain related behavior in treated mice [ 84 ]. Similarly, corneal nociception was notably reduced, inferred from the decreased eye wipes by mice forepaws, on which α-Bisabolol containing ointment was applied [ 85 ]. Furthermore, it was reported that α-Bisabolol had a synergistic effect in reducing nociception, inflammation and gastric injury when co-administered with diclofenac [ 86 ].…”

Antinociceptive effects of minor cannabinoids, terpenes and flavonoids in Cannabis

“…Bisabolol has also been tested in models of orofacial inflammation induced by formalin (Barreto et al , 2016; Melo et al , 2017), capsaicin (Barreto et al , 2016), glutamate (Barreto et al , 2016) and cinnamaldehyde (Melo et al , 2017), and hindpaw inflammation induced by formalin (Rocha et al , 2011) and carrageenan (Rocha et al , 2011). Bisabolol also produced antinociception against corneal pain when administered as an ointment or solution (Teixeira et al , 2017). Lastly, bisabolol alleviated neuropathic pain (Fontinele et al , 2019; Melo et al , 2019) and chronic inflammatory pain (Fontinele et al , 2019).…”