Corneal Biomechanical Properties in Different Ocular Conditions and New Measurement Techniques

García-Porta, Nery; Fernandes, Paulo; Queirós, António; Salgado-Borges, José; Parafita-Mato, Manuel A.; González-Meijóme, José Manuel

doi:10.1155/2014/724546

Cited by 89 publications

(91 citation statements)

References 170 publications

(272 reference statements)

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“…The anterior 40% of the central corneal stroma is the strongest region of the cornea, whereas the posterior 60% of the stroma is at least 50% weaker [24]. This biomechanical effect correlated with deeper ablation may be due to more central collagen and matrix material removed [6, 25]. The differences between Fang’ study and ours may stem from that they measured the corneal elastic modulus immediately after LASIK in vitro, the cornea didn’t undergo wound healing process.…”

Section: Discussionmentioning

confidence: 99%

Effects of ablation depth and repair time on the corneal elastic modulus after laser in situ keratomileusis

Wang

Chen

et al. 2017

BioMed Eng OnLine

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BackgroundThe biomechanical properties of the cornea should be taken into account in the refractive procedure in order to perform refractive surgery more accurately. The effects of the ablation depth and repair time on the elastic modulus of the rabbit cornea after laser in situ keratomileusis (LASIK) are still unclear.MethodsIn this study, LASIK was performed on New Zealand rabbits with different ablation depth (only typical LASIK flaps were created; residual stroma bed was 50 or 30% of the whole cornea thickness respectively). The animals without any treatment were served as normal controls. The corneal thickness was measured by ultrasonic pachymetry before animals were humanly killed after 7 or 28 days post-operatively. The corneal elastic modulus was measured by uniaxial tensile testing. A mathematical procedure considering the actual geometrics of the cornea was created to analyze the corneal elastic modulus.ResultsThere were no obvious differences among all groups in the elastic modulus on after 7 days post-operatively. However, after 28th days post-operatively, there was a significant increase in the elastic modulus with 50 and 30% residual stroma bed; only the elastic modulus of the cornea with 30% residual stroma bed was significantly higher than that of 7 days.ConclusionsChanges in elastic modulus after LASIK suggest that this biomechanical effect may correlate with the ablation depth and repair time.

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Section: Discussionmentioning

confidence: 99%

Effects of ablation depth and repair time on the corneal elastic modulus after laser in situ keratomileusis

Wang

Chen

et al. 2017

BioMed Eng OnLine

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“…1 In recent times, however new devices have been introduced which enable assessment of biomechanics in vivo in a clinical setting. Following are the commonly used biomechanical descriptors:…”

Section: Biomechanical Parametersmentioning

confidence: 99%

“…Corneal biomechanics involves the study of deformation and equilibrium of corneal tissues with the application of these forces. 1 Freidenwald was the first to describe the viscoelastic properties of the cornea in 1937, which were later elaborated by Nyquist and Woo.…”

Section: Introductionmentioning

confidence: 99%

CT | PDF | VIDEO Corneal Biomechanics: A Paradigm shift in Studying Corneal Pathology

Maru¹

2017

DJO

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“…However, a large range of values of Young's modulus have been reported varying from 0.1 to 57 MPa. 12 This can in part be explained by the viscoelastic nature of the cornea, however, there are many drawbacks to some of the techniques currently used such as strip extensometry, which affect the reliability of data and its usefulness when considering in vivo behaviour.…”

Section: Quantification Of Corneal Mechanical Propertiesmentioning

confidence: 99%

The role of light in measuring ocular biomechanics

Wilson

Marshall

Tyrer

2016

Eye

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The cornea is a highly specialised tissue with a unique set of biomechanical properties determined by its complex structure. The maintenance of these mechanical properties is fundamental to maintain clear vision as the cornea provides the majority of the focussing power of the eye. Changes to the biomechanics of the cornea can occur during ageing, disease, and trauma, or as a result of surgery. Recently there has been increased interest in the mechanical properties of the cornea as knowledge of these properties has significant implications for the improvement of current ocular treatments including PRK and LASIK, and for the diagnosis and tracking of corneal diseases and therapy such as keratoconus and crosslinking. Biomechanics are also important for the development of artificial corneal replacements. This paper describes the use of a novel, non-destructive lateral electronic speckle pattern shearing interferometer (ESPSI). The data generated via this technique give a full-field view of the mechanical response of the cornea under simulated physiological loading conditions, and enables strain and displacement to be determined in three planes. The technique allows corneal stiffness to be quantified and enables changes and non-homogeneities that occur due to surgery or disease to be detected.

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Corneal Biomechanical Properties in Different Ocular Conditions and New Measurement Techniques

Cited by 89 publications

References 170 publications

Effects of ablation depth and repair time on the corneal elastic modulus after laser in situ keratomileusis

Effects of ablation depth and repair time on the corneal elastic modulus after laser in situ keratomileusis

CT | PDF | VIDEO Corneal Biomechanics: A Paradigm shift in Studying Corneal Pathology

The role of light in measuring ocular biomechanics

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