2021
DOI: 10.1016/j.exer.2021.108508
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Corneal biomechanics: Measurement and structural correlations

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Cited by 42 publications
(38 citation statements)
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“…A major challenge is that the cornea has a complex tissue organization with a spatially inhomogeneous structure that is directionally anisotropic in its response to loading. Corneal collagen fibrils are preferentially oriented along the superior-inferior and nasal-temporal meridians in the central region and have circumferential orientation in the periphery ( Meek, 2009 ; Chong and Dupps, 2021 ). The regional and directional uniformity of the collagen fibril organization causes stiffness differences of the cornea in the lateral dimension.…”
Section: Discussionmentioning
confidence: 99%
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“…A major challenge is that the cornea has a complex tissue organization with a spatially inhomogeneous structure that is directionally anisotropic in its response to loading. Corneal collagen fibrils are preferentially oriented along the superior-inferior and nasal-temporal meridians in the central region and have circumferential orientation in the periphery ( Meek, 2009 ; Chong and Dupps, 2021 ). The regional and directional uniformity of the collagen fibril organization causes stiffness differences of the cornea in the lateral dimension.…”
Section: Discussionmentioning
confidence: 99%
“…Third, the cornea is composed of many extracellular materials and components with variable charge and chemical interactivity that are distributed inhomogeneously throughout the cornea. For example, the more hydrophilic glycosaminoglycans are found in the deep stroma and promote nonuniform swelling and viscous behaviors ( Chong and Dupps, 2021 ). In addition, ocular disease progression (e.g., keratoconus, ectasia, and glaucoma) and treatments (e.g., corneal cross-linking, refractive surgery) can also add complexity to the regional and directional variations in corneal structure and biomechanical behaviors.…”
Section: Discussionmentioning
confidence: 99%
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“…However, biomechanical measurement is complicated because the cornea is spatially inhomogeneous to lateral span and depth and is directionally anisotropic in its response to loading. [ 5 ]…”
mentioning
confidence: 99%