Corneal collagen cross-linking in keratoconus – long-term prospective study

Nicula, Cristina; Nicula, D; Popescu, Roxana; Saplonţai-Pop, Aniela

doi:10.1016/j.jfo.2014.10.007

Cited by 9 publications

(8 citation statements)

References 18 publications

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“…CXL is easy to perform and had no side effects for the endothelial cells, lens, and retina because riboflavin is a photosensibilizing agent for the production of reactive oxygen radicals and it has endothelial protection. [11,12] And, it is safe and effective in halting the progression of keratoconus in pediatric patients (under 19 years) at Uçakhan's 4-year follow-up. [13] …”

Section: Discussionmentioning

confidence: 99%

Outcomes of corneal crosslinking for central and paracentral keratoconus

Tian

Weiyan

et al. 2017

Medicine

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Background:The aim of the study was to compare the therapy of corneal collagen crosslinking (CXL) for central and paracentral keratoconus.Methods:64 eyes of 43 central keratoconus patients whose highest power of the cornea located in the central 3 mm zone and 24 eyes of 16 paracentral keratoconus patients whose highest power located out of the central 3 mm zone received standard corneal CXL were included. Maximum keratometry (Kmax) and astigmatism according to topography, uncorrected distant visual acuity (UDVA), corrected distant visual acuity (CDVA) were studied preoperatively and 2 years postoperatively.Results:Central group: Preoperative UDVA and CDVA were 0.9 ± 0.4 and 0.5 ± 0.4 logMAR, respectively. At 2 years, UDVA and CDVA significantly improved to 0.8 ± 0.4 and 0.4 ± 0.3 logMAR(P < 0.01). Preoperative Kmax and astigmatism were 61.5 ± 14.7 diopter (D) and 4.0 ± 2.9 D, respectively. At 2 years, Kmax and astigmatism significantly decreased to 57.0 ± 10.4 and 3.0 ± 2.2 D (P < 0.01). Paracentral group: preoperative UDVA and CDVA were 0.8 ± 0.7 and 0.2 ± 0.4 logMAR, respectively. At 2 years, UDVA significantly improved to 0.4 ± 0.4 logMAR(P < 0.01), whereas CDVA remained 0.2 ± 0.3 logMAR(P > 0.05). Preoperative Kmax and astigmatism were 50.3 ± 5.3 and 2.4 ± 1.7 D, respectively. At 2 years, Kmax significantly decreased to 48.8 ± 4.6 (P < 0.01), whereas astigmatism remained 2.2 ± 1.8 D (P > 0.05).Conclusion:This study indicated that CXL was more effective for central keratoconus than paracentral keratoconus.

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Section: Discussionmentioning

confidence: 99%

Outcomes of corneal crosslinking for central and paracentral keratoconus

Tian

Weiyan

et al. 2017

Medicine

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“…Longitudinal and long-term follow-up studies have shown an acceptable safety for this technique, and extremely rare complications have been reported in patients. [ 21 22 23 24 25 ] CXL that was originally introduced to slow or ideally prevent further progression of KC has shown to be efficient in improvement of clinical, topographical, and aberrometric indices. [ 8 10 11 13 ] As with most of the studies in the literature, we found a significant improvement in mean K, CCT, MRSE, UCVA, and BCVA 4-year-postoperation, which indicates the corneal stability induced by CXL.…”

Section: Discussionmentioning

confidence: 99%

“…[ 8 10 11 13 ] As with most of the studies in the literature, we found a significant improvement in mean K, CCT, MRSE, UCVA, and BCVA 4-year-postoperation, which indicates the corneal stability induced by CXL. [ 21 22 23 24 25 ]…”

Section: Discussionmentioning

confidence: 99%

Higher-order aberration 4 years after corneal collagen cross-linking

Naderan

Jahanrad

2017

Indian J Ophthalmol

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Purpose:Corneal collagen cross-linking (CXL) is a treatment strategy used in keratoconic eyes. Evaluation of long-term changes of higher-order aberrations (HOAs) after CXL is useful in understanding the efficacy of this procedure in improving optical, refractive, and visual acuity. This study aims to investigate the long-term effect of CXL on ocular HOA in patients with progressive keratoconus (KC).Methods:Using an OPD-Scan II aberrometer, ocular HOAs measurements of 56 eyes of 56 patients that underwent CXL was evaluated at the baseline, 1, 2, and 4 years after the procedure. All OPD-Scan measurements were decomposed into Zernike coefficients from 3rd to 6th order.Results:The results revealed that except for a few parameters, most of the aberration parameters continuously decreased during the study. In the 4-year postoperative period, a statistically significant improvement in all HOA parameters except 5th order Zernike polynomials (Z51, Z5−1, Z53, Z5−3, Z55, and Z5−5) was observed. All the values significantly decreased compared to the preoperative measurements (P < 0.05). The mean ± standard deviation (SD) root mean square of the 3rd, 4th, and the 5th order as well as coma, coma like, and total HOA parameters were significantly decreased compared to both preoperative and previous visits (P < 0.001). There were significant correlations between preoperative measurements of HOAs parameters with best-corrected visual acuity (BCVA) including Z31, Z3−1, Z40, Z51, and Z42. Moreover, all the HOAs parameters in 4 years after the CXL were significantly correlated with BCVA (P < 0.05).Conclusion:CXL is effective in improving HOA parameters in eyes with progressive KC during a long-term follow-up.

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“…[thamkar,thamkar] For both Tamhankar et al studies success with prism was defined as complete or partial resolution of diplopia based on patient report. In the first study, of 94 patients with a range of motility disorders, 88% were considered successfully treated (12) and in the other study, of 64 patients with large angle, incomitant, or combined horizontal and vertical strabismus, 72% were successfully treated (30).There are conditions where optic corrections fail due to other ophthalmological disorders (40,41), due to associated neurological symptoms, or due to cognitive severe impairments (42). Another treatment for diplopia is the injection of botulinum toxin which blocks local synaptic transmission at cholinergic terminals.…”

Section: Prescription Of Prismsmentioning

confidence: 99%

Non-surgical correction of diplopia after stroke- a strong impact factor on quality of life-minireview

Nicula

Nicula²,

Bulboacă

2019

BALNEO

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One of the most frequent disorders accompanied by diplopia is represented by stroke. Beyond different symptoms of stroke, diplopia constitutes an important clinical factor in influencing the quality of life in surviving patients. In this paper we discuss the visual impairment associated with stroke location, types of diplopia, the clinical examination, and the nonsurgical treatment of diplopia. The purpose of diplopia treatment is to restore binocular vision and eliminate the double vision. The most used nonsurgical treatment for diplopia is the optical correction by the prisms. Another therapeutic option is the botulinum toxin injections. Key words: diplopia, stroke, visual rehabilitation, prism correction,

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Corneal collagen cross-linking in keratoconus – long-term prospective study

Cited by 9 publications

References 18 publications

Outcomes of corneal crosslinking for central and paracentral keratoconus

Outcomes of corneal crosslinking for central and paracentral keratoconus

Higher-order aberration 4 years after corneal collagen cross-linking

Non-surgical correction of diplopia after stroke- a strong impact factor on quality of life-minireview

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