Corneal Endothelial Changes in Type I and Type II Diabetes Mellitus

Schultz, Richard O.; Matsuda, Michihiko; Yee, Richard W.; Edelhauser, Henry F.; Schultz, Karen J.

doi:10.1016/0002-9394(84)90120-x

Cited by 335 publications

(185 citation statements)

References 14 publications

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“…Inoue et al, however, reported that people with type 2 DM have damaged corneal endothelial structure but found similar CCT values compared with non-diabetic subjects. [38][39][40] In people with type 1 DM, Schultz et al 40 observed similar CCT values to those of healthy subjects, while Roszkowska et al 37 found a significant increase in type 1 DM patients.…”

Section: Tear Filmmentioning

confidence: 99%

“…In diabetic corneas, endothelial cells show morphological abnormalities such as high coefficient of variation of cell area and a decrease in the percentage of hexagonal cells. 27,28,[37][38][39][40] Although there are many reports about corneal endothelium in people with DM, the results remain controversial. Inoue et al 38 found a decrease of 4.1% in endothelial cell density in patients with type 2 DM and a higher coefficient of variation of cell area but did not observe a decrease in the percentage of hexagonal cells.…”

Section: Tear Filmmentioning

confidence: 99%

“…29,40 Regarding endothelial cell hexagonality loss (pleomorphism), some authors reported a decrease in the percentage of hexagonal cells. 37,40 A number of studies have shown that people with DM have decreased corneal sensitivity, 17,19,21,22,27,28,33 make them more vulnerable to corneal trauma. Thickening and thinning of Schwann cell basal lamina, irregular distribution in the nerve beading pattern, and occasional axonal degeneration of the nonmyelinated corneal nerves have been found in people with DM.…”

Section: Tear Filmmentioning

confidence: 99%

See 2 more Smart Citations

Optical quality of the diabetic eye: a review

Calvo-Maroto

Pérez-Cambrodí²,

Albarán-Diego

et al. 2014

Eye

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Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyperglycaemia. Several structural, morphological, and physiological changes in each of ocular component have been described in detail during the past decades. Due to these abnormalities, the diabetic patient undergoes a degradation of the retinal image by an increase of higher ocular aberrations and ocular scattering coming from mainly tear film, cornea, and crystalline lens. This review aims to provide an overview of current knowledge about the effects of diabetes mellitus in these optical phenomena and its consequence on the visual quality of the diabetic patient.

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Section: Tear Filmmentioning

confidence: 99%

Section: Tear Filmmentioning

confidence: 99%

Section: Tear Filmmentioning

confidence: 99%

See 1 more Smart Citation

Optical quality of the diabetic eye: a review

Calvo-Maroto

Pérez-Cambrodí²,

Albarán-Diego

et al. 2014

Eye

View full text Add to dashboard Cite

show abstract

“…Anatomical as well as physiological changes occur in the cornea. Previous studies by Busted et aland Schultz et al [2,3] concluded increased polymegathism, polymorphism with increased central corneal thickness (CCT) and normal endothelial cell density (ECD). Other recent studies by Roszkowska et hydration and increased CCT.…”

Section: Introductionmentioning

confidence: 99%

Changes in the Central Corneal Thickness in Diabetes Mellitus Patients with age and Gender Matched Healthy Controls in North Indian Population

Makkar¹,

Srivastav²,

Mishra³

et al. 2018

AIMDR

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Background: Since diabetes mellitus affects the all part of body including ocular structures so we planned a study to compare the central corneal thickness in diabetes mellitus patients with age and sex matched healthy controls in North Indian population. The aim of our study was to compare the central corneal thickness in diabetes mellitus patients with age and sex matched healthy controls in North Indian population. Methods: It was a prospective clinical study done at tertiary care centre on two hundred patients. Out of them 100 were diabetic and 100 were healthy subjects. The CCT measurement was done in enrolled patient using a non contact ultrasonic pachymeter probe gently placed in the mid pupillary axis of the cornea in undilated eye. All CCT and IOP recordings were done between 12-2 pm keeping in mind the diurnal fluctuations. Data was analysed by SPSS Software version16. Results: CCT was higher in diabetics having duration > 10 years than those having duration < 10 years.Central corneal thickness values increased from patients with no diabetic retinopathy to those with proliferative retinopathy. Conclusion: The cornea of diabetics is significantly (P≤0.001) thicker than normal healthy subjects.

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“…Morphologic changes of CECs include increased variation in cell size (polymegethism) and in cell shape (pleomorphism). [11][12][13][14] Both polymegethism and pleomorphism are wellestablished parameters that are used to measure endothelial cell function and CEC responses to endogenous as well as exogenous stimuli. 11 Inflammation after corneal transplantation leads to increased apoptosis of the corneal endothelium, and loss of CECs during graft rejection has been observed in both rodent and human corneal transplants.…”

Section: Introductionmentioning

confidence: 99%

Quantification of allospecific and nonspecific corneal endothelial cell damage after corneal transplantation

Chauhan

Jurkunas

Funaki

et al. 2014

Eye

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Purpose To investigate the effect of host immunity (allospecific) and surgical manipulation (non-allospecific) on corneal endothelial cells (CECs) in corneal transplantation. Methods Draining lymph nodes and grafted C57BL/6 corneas were harvested from syngeneic recipients, allograft acceptors, and allograft rejectors (BALB/c) 1, 3, and 8 weeks after transplantation. We analyzed CEC apoptosis using an ex vivo cornea-in-the-cup assay, and visualized cell-to-cell junctions using immunohistochemical staining (ZO-1). Automatic cell analysis using Confoscan software was used to measure CEC density as well as changes in CEC morphology by quantifying the coefficient of variation in cell size (polymegethism) and shape (pleomorphism). Results The cornea-in-the-cup assay showed that allogeneic acceptor T cells and to an even greater extent rejector T cells (but not syngeneic T cells) induced CEC apoptosis. CEC density after corneal transplantation was significantly reduced in allogeneic acceptors compared with syngeneic grafts (Po0.001), and CEC density was even further reduced in the allo-rejector group compared with the allo-acceptor group. Allogeneic grafts showed a greater increase in the coefficient of variation in cell size (polymegethism) when compared with syngeneic grafts 1 week after transplantation (P ¼ Po0.001). However, pleomorphism was not significantly different between syngeneic and allo-acceptor grafts, indicating that polymegethism (but not pleomorphism or cell density) is a sensitive indicator of the effect of alloimmunity on CECs. Conclusions Our data demonstrate that host alloimmunity rather than surgical manipulation alone is the major cause of CEC damage in corneal transplantation, and such morphologic changes of CECs can be detected before the clinically visible onset of allograft rejection.

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Corneal Endothelial Changes in Type I and Type II Diabetes Mellitus

Cited by 335 publications

References 14 publications

Optical quality of the diabetic eye: a review

Optical quality of the diabetic eye: a review

Changes in the Central Corneal Thickness in Diabetes Mellitus Patients with age and Gender Matched Healthy Controls in North Indian Population

Quantification of allospecific and nonspecific corneal endothelial cell damage after corneal transplantation

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