Optical quality of the diabetic eye: a review

Calvo-Maroto, Ana M.; Pérez-Cambrodí, Rafael J.; Albarán-Diego, C; Pons, A.; Cerviño, Alejandro

doi:10.1038/eye.2014.176

Cited by 42 publications

(33 citation statements)

References 87 publications

(164 reference statements)

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“…In DM, diffusion of glucose from the aqueous humor through the cornea occurs when there is a breakdown of the blood–aqueous barrier, resulting in a glucose gradient in the cornea . An increase in non‐enzymatic glycation in corneal proteins and collagen (via the Maillard reaction) also occurs in DM, resulting in increased corneal AF …”

Section: Ocular Af In Diabetesmentioning

confidence: 99%

Ocular autofluorescence in diabetes mellitus. A review

Calvo-Maroto

Pérez-Cambrodí²,

García‐Lázaro

et al. 2016

Journal of Diabetes

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Diabetes mellitus is a metabolic disease with a considerable impact on healthcare owing to its increased prevalence and high mortality rate. Structural, morphological, and physiological changes in each of the ocular components have been described in detail. Autofluorescence has been described as a good indicator of metabolic activity. The aim of the present review is to provide an overview of ocular endogenous fluorophores in the cornea, the crystalline lens, and the retinal pigment epithelium, the effects of diabetes mellitus and therefore the potential of autofluorescence assessment for screening and monitoring changes in diabetic patients.

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Section: Ocular Af In Diabetesmentioning

confidence: 99%

Ocular autofluorescence in diabetes mellitus. A review

Calvo-Maroto

Pérez-Cambrodí²,

García‐Lázaro

et al. 2016

Journal of Diabetes

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“…Earlier reviews on diabetic corneal disease focused primarily on clinical problems (Sánchez-Thorin, 1998; Cisarik-Fredenburg, 2001; Kaji, 2005). More recently, appropriate attention was given to mechanisms of disease and available therapies (Bikbova et al, 2012; Calvo-Maroto et al, 2014; Misra et al, 2016; Vieira-Potter et al, 2016; Shih et al, 2017). This review provides recent updates in this rapidly developing field and analyzes in more detail the latest therapeutic candidates.…”

Section: Introductionmentioning

confidence: 99%

Diabetic complications in the cornea

2017

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Diabetic corneal alterations, such as delayed epithelial wound healing, edema, recurrent erosions, neuropathy/loss of sensitivity, and tear film changes are frequent but underdiagnosed complications of both type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus. The disease affects corneal epithelium, corneal nerves, tear film, and to a lesser extent, endothelium, and also conjunctiva. These abnormalities may appear or become exacerbated following trauma, as well as various surgeries including retinal, cataract or refractive. The focus of the review is on mechanisms of diabetic corneal abnormalities, available animal, tissue and organ culture models, and emerging treatments. Changes of basement membrane structure and wound healing rates, the role of various proteinases, advanced glycation end products (AGEs), abnormal growth and motility factors (including opioid, epidermal, and hepatocyte growth factors) are analyzed. Experimental therapeutics under development, including topical naltrexone, insulin, inhibitors of aldose reductase and AGEs, as well as emerging gene and cell therapies are discussed in detail.

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“…It affects multiple ocular structures and leads to several complications, such as diabetic retinopathy, cataracts, glaucoma, optic neuropathy, and dry eye (2). Studies have shown that 70% of patients with diabetes have corneal abnormalities, generally described as diabetic keratopathy (3–8).…”

Section: Introductionmentioning

confidence: 99%

Recovery of Corneal Sensitivity and Increase in Nerve Density and Wound Healing in Diabetic Mice After PEDF Plus DHA Treatment

Pham

Kakazu

et al. 2017

Diabetes

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Diabetic keratopathy decreases corneal sensation and tear secretion and delays wound healing after injury. In the current study, we tested the effect of treatment with pigment epithelium-derived factor (PEDF) in combination with docosahexaenoic acid (DHA) on corneal nerve regeneration in a mouse model of diabetes with or without corneal injury. The study was performed in streptozotocin-induced diabetic mice (C57BL/6). Ten weeks after streptozotocin injection, diabetic mice showed significant decreases of corneal sensitivity, tear production, and epithelial subbasal nerve density when compared with age-matched normal mice. After diabetic mice were wounded in the right eye and treated in both eyes with PEDF+DHA for 2 weeks, there was a significant increase in corneal epithelial nerve regeneration and substance P–positive nerve density in both wounded and unwounded eyes compared with vehicle-treated corneas. There also was elevated corneal sensitivity and tear production in the treated corneas compared with vehicle. In addition, PEDF+DHA accelerated corneal wound healing, selectively recruited type 2 macrophages, and prevented neutrophil infiltration in diabetic wounded corneas. These results suggest that topical treatment with PEDF+DHA promotes corneal nerve regeneration and wound healing in diabetic mice and could potentially be exploited as a therapeutic option for the treatment of diabetic keratopathy.

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Optical quality of the diabetic eye: a review

Cited by 42 publications

References 87 publications

Ocular autofluorescence in diabetes mellitus. A review

Ocular autofluorescence in diabetes mellitus. A review

Diabetic complications in the cornea

Recovery of Corneal Sensitivity and Increase in Nerve Density and Wound Healing in Diabetic Mice After PEDF Plus DHA Treatment

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