Corneal Epithelial Defects After Smoking Crack Cocaine

McHenry, John G.; Zeiter, John H.; Madion, Matthew P.; Cowden, John W.

doi:10.1016/0002-9394(89)90871-4

Cited by 27 publications

(16 citation statements)

References 2 publications

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“…Sachs et al 13 used the term "crack eye syndrome" to describe the corneal findings of superficial punctate epithelial keratopathy, corneal epithelial defects, and infectious keratitis associated with smoking crack cocaine. Corneal epithelial defects were first described by McHenry et al 14 in 1989. The exact mechanism is not completely understood, but it was postulated that cocaine disrupts plasma membranes and cytoplasm resulting in alteration of corneal epithelial cell function.…”

Section: Commentmentioning

confidence: 99%

Nasolacrimal Duct Obstruction and Orbital Cellulitis Associated With Chronic Intranasal Cocaine Abuse

et al. 1999

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To report the association of acquired nasolacrimal duct obstruction and orbital cellulitis in patients with a history of chronic intranasal cocaine abuse. Methods: Retrospective, consecutive case series. Results of imaging, histopathologic examinations, and clinical courses of these patients were studied. Results: Five women and 2 men (mean age, 41 years) with a history of chronic intranasal cocaine abuse (mean, 11 years; range, 5-20 years) presented with epiphora and in some cases acute onset of periorbital pain, edema, and erythema associated with fever. The suspicion of intranasal cocaine abuse was made on anterior rhinoscopy with the detection of an absent nasal septum and inferior turbinate. Computed tomographic and magnetic resonance imaging findings in 4 patients included extensive bony destruction of the normal orbital wall architec

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Section: Commentmentioning

confidence: 99%

Nasolacrimal Duct Obstruction and Orbital Cellulitis Associated With Chronic Intranasal Cocaine Abuse

et al. 1999

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“…A few cases of acquired anterior staphyloma associated with drug abuse have been reported in the literature. In 1989, McHenry et al (9) first described corneal epithelial defects that were associated with crack cocaine. Since then, others have reported regarding corneal damage caused by narcotics (3)(4)(5) .…”

Section: Discussionmentioning

confidence: 99%

Acquired anterior staphyloma after corneal ulcer associated with the use of crack

Vasconcelos

Guerra

Morato

et al. 2016

Arquivos Brasileiros De Oftalmologia

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CASE REPORTA 30-year-old black man presented with a 4-week history of a foreign body sensation, redness, and pain in his right eye. His left eye was stable. The patient had a history of crack cocaine and injected heroin abuse. He was homeless and admitted to using crack cocaine daily over the past 4 months. He denied any previous contact lens use, trauma, or ocular surgery. He was otherwise quite well with no systemic symptoms, and his general medical history was unremarkable.On examination at our hospital, uncorrected visual acuity was found to be light perception (LP) in the right eye and 20/25 in the ABSTRACTWe describe an unusual case of acquired anterior staphyloma in a patient addicted to crack cocaine. At the beginning of his crack cocaine abuse, he noticed redness and irritation of his eyes. Over the next 4 months, the patient also noticed the onset of decreasing visual acuity in his right eye (OD). Initially, his visual acuity was light perception in OD, and slit-lamp examination revealed a corneal infiltrate with a peripheral perforation and an iris prolapse. The patient was hospitalized to ensure compliance with the prescribed treatment and was advised to undergo therapeutic keratoplasty; however, the patient left the hospital against medical advice and was lost to follow-up for the next 6 months. He returned with complaints of photophobia and the inability to close his right eyelids. At this time, his cornea had developed an anterior staphyloma and required a sclerokeratoplasty. Following surgery, the patient was again lost to follow-up.

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“…It is interesting to note that similar corneal complica tions have been reported following the use of crack cocaine. Corneal epithelial defects following the use of crack cocaine were first described by McHenry et al 4 These epithelial defects may lead to frank corneal ulcer ation and infectious keratitis. s Sachs et als have noted that crack cocaine smoke may have a direct toxic effect on the corneal epithelium and also may lead to damage because of possible corneal anaesthesia.…”

Section: Discussionmentioning

confidence: 99%