Corneal Epithelium Thickness Profile in 614 Normal Chinese Children Aged 7–15 Years Old

Ma, Yingyan; He, Xiangui; Zhu, Xiaofeng; Lu, Lina; Zhu, Jianfeng; Zou, Haidong

doi:10.1038/srep23482

Cited by 12 publications

(14 citation statements)

References 37 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thereafter, the scar tissues were formed after corneal edema was repaired, which undoubtedly caused the irregular changes of epithelial thickness in the scarring KC. Since the thickness profiles in some stages of KC had never been investigated based on the AS-OCT, the findings not only supported the previous studies (Li et al, 2012;Ma et al, 2016;Xu et al, 2016;Morishige et al, 2019;Wang et al, 2019;Yang et al, 2020;Toprak et al, 2021), but also provided new evidence for the KC features at different stages. Furthermore, our experimental results with the linear discriminant analysis revealed that the measured thickness indices could be used to differentiate the groups of different KC stages from normal eyes.…”

Section: Discussionsupporting

confidence: 82%

“…Although the corneal thickness profiles including the epithelial layer have been investigated based on AS-OCT images (Chen et al, 2012;Corre-Perez et al, 2012;Li et al, 2012;Wu et al, 2014;Ma et al, 2016;Xu et al, 2016;Ang et al, 2018;Mathai et al, 2019;Morishige et al, 2019;Ouyang et al, 2019;Santos et al, 2019;Wang et al, 2019;Yang et al, 2020;Toprak et al, 2021), none of them was able to successfully classify the KC into different stages based on the CLEK guidelines (Zadnik et al, 1998). Often, all the KC eyes are considered as a group when compared with normal eyes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dissecting the Profile of Corneal Thickness With Keratoconus Progression Based on Anterior Segment Optical Coherence Tomography

Dong

Guo

et al. 2022

Front. Neurosci.

View full text Add to dashboard Cite

PurposeTo characterize the corneal and epithelial thickness at different stages of keratoconus (KC), using a deep learning based corneal segmentation algorithm for anterior segment optical coherence tomography (AS-OCT).MethodsAn AS-OCT dataset was constructed in this study with 1,430 images from 715 eyes, which included 118 normal eyes, 134 mild KC, 239 moderate KC, 153 severe KC, and 71 scarring KC. A deep learning based corneal segmentation algorithm was applied to isolate the epithelial and corneal tissues from the background. Based on the segmentation results, the thickness of epithelial and corneal tissues was automatically measured in the center 6 mm area. One-way ANOVA and linear regression were performed in 20 equally divided zones to explore the trend of the thickness changes at different locations with the KC progression. The 95% confidence intervals (CI) of epithelial thickness and corneal thickness in a specific zone were calculated to reveal the difference of thickness distribution among different groups.ResultsOur data showed that the deep learning based corneal segmentation algorithm can achieve accurate tissue segmentation and the error range of measured thickness was less than 4 μm between our method and the results from clinical experts, which is approximately one image pixel. Statistical analyses revealed significant corneal thickness differences in all the divided zones (P < 0.05). The entire corneal thickness grew gradually thinner with the progression of the KC, and their trends were more pronounced around the pupil center with a slight shift toward the temporal and inferior side. Especially the epithelial thicknesses were thinner gradually from a normal eye to severe KC. Due to the formation of the corneal scarring, epithelial thickness had irregular fluctuations in the scarring KC.ConclusionOur study demonstrates that our deep learning method based on AS-OCT images could accurately delineate the corneal tissues and further successfully characterize the epithelial and corneal thickness changes at different stages of the KC progression.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Dissecting the Profile of Corneal Thickness With Keratoconus Progression Based on Anterior Segment Optical Coherence Tomography

Dong

Guo

et al. 2022

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Central corneal thickness (CCT) is also an independent risk factor for glaucoma, and potential factors affecting corneal thickness measurements or their association with IOP measurements have been extensively studied [3,4]. The recent development of topographic mapping using Fourier domain optical coherence tomography (FD-OCT) has enabled the measurement of corneal epithelial thickness (CET) as well as corneal thickness in the clinical routine with various clinical applications [5][6][7]. The corneal epithelium is one of the main structures that undergo degenerative alterations in ocular diseases.…”

Section: Introductionmentioning

confidence: 99%

Changes in Corneal Epithelial Thickness Induced by Topical Antiglaucoma Medications

Nam

Kim

2021

JCM

View full text Add to dashboard Cite

Corneal thickness measurement is important for assessing intraocular pressure in patients with glaucoma. This study investigated the changes in corneal epithelial thickness (CET) induced by antiglaucoma medications and explored the factors affecting CET measurement. CET was measured over a 9.0 mm diameter area by using Fourier domain optical coherence tomography in 125 patients with primary open-angle glaucoma and 125 age-matched controls without glaucoma. The influence of sex, age, benzalkonium chloride (BAK)-containing instillations, disease severity, and types and numbers of medications was analyzed using simple and multiple regression analyses. CET over 25 sectors was smaller in the glaucoma group than in the control group (mean difference of 4.2 µm in the central 2.0 mm zone; 52.8 ± 3.6 vs. 48.5 ± 3.9, p < 0.001). Simple regression analysis revealed age, use of β-blockers, prostaglandin, carbonic anhydrase inhibitors, total number of medications, and number of daily BAK-containing instillations were associated with a thinner epithelium. Multiple regression analysis revealed β-blockers, prostaglandin, and number of BAK-containing instillations were significant factors. Use of β-blockers and number of BAK-containing instillations were also associated with a thinner epithelium in the monotherapy subgroup analysis. CET was significantly smaller in patients with glaucoma receiving topical medications and was affected by the use of β-blockers, prostaglandin, and BAK.

show abstract

“…The ratio of epithelial to corneal thickness may be a more sensitive criterion for diagnosing dry eye syndrome than simply epithelial thickness as previously suggested. In dry eye syndrome, the thickness of the epithelium increases, but this may be invisible in patients with initially thin epithelium, because even with thickening in patients with a thin cornea, the thickness of the epithelium may not exceed normal values [18].…”

Section: Aim Of the Workmentioning

confidence: 99%

Patogenetic relationship between the corneal epithelial thickness and microcirculation in the conjunctiva during optical coherent tomography in healthy subjects without ophthalmopathology

Луценко

Unguryan

2020

J Educ Health Sport

View full text Add to dashboard Cite

Relevance. The ocular surface is composed of various tissue components, and all of these components work together to maintain the integrity and normal function of the ocular surface. Aim of the work: to study of indicators of the blood flow of the bulbar conjunctiva and the state of the corneal epithelium in a group of conventionally healthy individuals and assessment of their physiological relationship. Materials and methods. The study involved 20 apparently healthy people (40 eyes) of the Caucasian race, aged from 25 to 53, without concomitant ophthalmopathology. During the examinations, the state of the cornea (thickness of the cornea, epithelium) and bulbar conjunctiva 94 were determined. The study of patients was carried out for 5 months from May to October 2020 on the basis of the Department of Eye Diseases of the State Institution "Zaporozhye Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine" in the Department of Eye Microsurgery in Zaporizhzhia Regional Clinical Hospital. Results. With the help of angio-optical coherence tomography, the density of vessels of the superficial and deep plexuses of the conjunctiva were studied and the normative base of conventionally healthy patients was formed. The density of the vessels of the superficial plexus at a distance of 1, 2 and 3 mm from the limbus did not differ significantly and averaged 50.7 µm. The density of the vessels of the deep plexus on average was 55.7 µm, but did not differ significantly from the indices of the superficial plexus. In the study of the density of the vascular bed of the deep plexus, statistically significant (p<0.05) more intense blood flow was noted at a distance of 2 mm from the limbus, and the lowest density of vessels at the level of 1 mm from the limbus. A statistically significant associative logical relationship between the dynamics of the thickness of the cornea and its epithelium was established, and the ratio of the thickness of the cornea to its epithelium was calculated in practically healthy individuals, which is within 9-11 conv. units. Conclusions. The proposed normative reference values of a group of healthy individuals will allow both to adequately assess the functional ability of the corneal epithelium, to assess the density of blood flow of the bulbar conjunctiva and episclera, and to timely rationally select personally pathogenetically justified treatment and rehabilitation measures, taking into account the severity of pathological changes in the cornea at the subclinical stage.

show abstract

Corneal Epithelium Thickness Profile in 614 Normal Chinese Children Aged 7–15 Years Old

Cited by 12 publications

References 37 publications

Dissecting the Profile of Corneal Thickness With Keratoconus Progression Based on Anterior Segment Optical Coherence Tomography

Dissecting the Profile of Corneal Thickness With Keratoconus Progression Based on Anterior Segment Optical Coherence Tomography

Changes in Corneal Epithelial Thickness Induced by Topical Antiglaucoma Medications

Patogenetic relationship between the corneal epithelial thickness and microcirculation in the conjunctiva during optical coherent tomography in healthy subjects without ophthalmopathology

Contact Info

Product

Resources

About