Corneal hemangiosarcoma in a cat

Cazalot, Guillaume; Régnier, A.; Deviers, A.; Serra, F.; Lucas, Marie-Noëlle; Etienne, Claire Lyse; Raymond‐Letron, Isabelle

doi:10.1111/j.1463-5224.2011.00928.x

Cited by 13 publications

(17 citation statements)

References 28 publications

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“…Hemangiosarcoma is a malignant neoplasm of vascular endothelial cells origin and it may be associated to chronic inflammation and neoplastic transformation. It was reported in previous studies [2,6], and it could be a hypothesis for the presented clinical case. There are two cases described in the literature of abdominal wall tumor associated with foreign body and exuberant inflammatory response in cats using different types of suture; one case is a steel staple developing hemangiosarcoma [6] and the other is polyester sutures developed fibrosarcoma [1].…”

Section: Discussionsupporting

confidence: 77%

Hemangiosarcoma Associated with Polypropylene Suture in a Cat

Corgozinho¹,

Caloeiro²,

Figliuolo³

et al. 2018

Acta Scientiae. Vet.

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Background:Sutures plays an important role in wound repair by providing hemostasis and support for healing suture. Synthetic non-absorbable like polypropylene suture materials induce minimal tissue reaction. Polypropylene has not been associated to neoplasms in domestic animals. The aim this study is to describe the first case of polypropylene suture induced hemangiosarcoma in an abdominal wall of a feline. Case: A 13-year-old female domestic shorthair cat was presented with a ventral abdominal subcutaneous mass. Clinical examination revealed a firm, rough, and irregular, approximately 6 x 4 cm subcutaneous mass involving the caudal ventral abdomen. A complete blood (cell) count (CBC) was within normal limits. Leukemia and FIV tests were negative; and the results of a chemistry panel revealed elevated creatinine (valor: 2.0 reference range: 0.5-1.9). Abdominal ultrasound revealed a large mass of mixed echogenicity in the mid-ventral abdomen cranial to the bladder, measuring approximately 6 x 4 cm in the middle line with suture deeply embedded within mass suggesting foreign body reaction or neoplasm. There was evidence of sutures (hyperechoic lines) along the caudal abdominal wall extending into the mass. Records indicated that ovariohysterectomy procedure was performed 12 years previously at the same clinic and the closure of the abdominal wall was made with polypropylene sutures. No other abdominal surgery was performed in this cat. A fine-needle aspirate of the mass and contrast-enhanced computed tomography was not performed due to owner's finance restrains. The cat was referred to surgery and the mass was excised. No evidence of metastasis was noted during surgery. Histologically, the neoplastic cells were oval to round with granular cytoplasm and vesicular nucleus and exhibited moderate cellular and nuclear pleomorphism.

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Section: Discussionsupporting

confidence: 77%

Hemangiosarcoma Associated with Polypropylene Suture in a Cat

Corgozinho¹,

Caloeiro²,

Figliuolo³

et al. 2018

Acta Scientiae. Vet.

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“…48 CD-31 expression has also been reported in neoplasms in both dogs and cats. 49,50 Positive expression of CD-31 in this case is indicative of a neoplasm of endothelial origin. Vascular endothelial growth factor (VEGF) is a signaling protein found in normal ophthalmic tissues.…”

Section: Discussionmentioning

confidence: 72%

“…Immunohistochemistry for CD‐31 has been reported in horses to aid in the diagnosis of hemangiosarcoma . CD‐31 expression has also been reported in neoplasms in both dogs and cats . Positive expression of CD‐31 in this case is indicative of a neoplasm of endothelial origin.…”

Section: Discussionmentioning

confidence: 73%

Presumed primary ocular lymphangiosarcoma with metastasis in a miniature horse

Gerding

Gilger

Montgomery

et al. 2015

Veterinary Ophthalmology

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A 7-year-old, 153.0-kg American Miniature mare presented for evaluation of keratoconjunctivitis of the right eye (OD). A superior palpebral conjunctival mass and stromal keratitis were diagnosed. The incisional biopsy diagnosis was a presumptive corneal hemangiosarcoma. Transpalpebral enucleation was performed, and histopathologic evaluation confirmed angiosarcoma of the conjunctiva, cornea, and extraocular muscles. The horse developed progressive epistaxis and orbital swelling following surgery. A systemic workup was performed 3 months after enucleation, revealing regrowth within the orbit and marked cranial cervical lymphomegaly, suggestive of metastasis. Humane euthanasia was performed, and necropsy confirmed a locally invasive periorbital tumor with metastasis to the submandibular tissue, submandibular lymph node, and thoracic inlet. Histopathologic evaluation of necropsy specimens revealed polygonal to spindle neoplastic cells lining neoplastic vascular channels lacking erythrocytes. Immunohistochemically, the neoplastic cells labeled strongly positive for PROX-1, vimentin, CD-31, VEGF, weakly positive for factor VIII-related antigen, and negative for collagen IV. Based on the clinical, histological, and immunohistochemical features of this tumor, a primary ocular lymphangiosarcoma with metastasis was diagnosed.

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“…Most tumors of the cornea represent extension from conjunctival, intraocular, or limbal masses. Published cases of primary corneal neoplasms in veterinary species include squamous cell carcinoma, hemangioma, hemangiosarcoma, lymphangioma, lymphangiosarcoma, papilloma, adenocarcinoma, angiokeratoma, and lymphoma . The most common primary corneal neoplasms in veterinary species are viral papilloma and squamous cell carcinoma, predominantly occurring in horses and cattle, and less often in cats and dogs …”

Section: Discussionmentioning

confidence: 99%

“…Feline corneal vascular tumors published in the literature are predominantly primary scleral, conjunctival, or eyelid masses with corneal involvement, rather than primary corneal neoplasms. Only 2 individual case reports of corneal vascular tumors were identified in the literature . One case also had concurrent corneal squamous cell carcinoma in addition to corneal hemangiosarcoma (collision tumors) …”

Section: Introductionmentioning

confidence: 99%

Canine, feline, and equine corneal vascular neoplasia: A retrospective study (2007‐2015)

Shank

Teixeria

Dubielzig

2018

Veterinary Ophthalmology

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Corneal vascular neoplasms (hemangioma and hemangiosarcoma) are rare in all species. Reported cases are single case reports in a single species. Archived cases of corneal hemangioma and hemangiosarcoma from dogs, cats, and horses were obtained from the Comparative Ocular Pathology Lab of Wisconsin (COPLOW, Madison, WI), tabulated, and examined. This retrospective study describes the breeds, ages, tumor types, and characteristics of vascular neoplasms that appeared to be primarily corneal in location, in feline, canine, and equine patients, with gross and histologic images. There is a discussion of predisposing factors and speculated association with chronic ocular surface disease.

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Corneal hemangiosarcoma in a cat

Cited by 13 publications

References 28 publications

Hemangiosarcoma Associated with Polypropylene Suture in a Cat

Hemangiosarcoma Associated with Polypropylene Suture in a Cat

Presumed primary ocular lymphangiosarcoma with metastasis in a miniature horse

Canine, feline, and equine corneal vascular neoplasia: A retrospective study (2007‐2015)

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