Corneal Perforation in Patients With Vitamin A Deficiency in the United States

Suan, Eric P.; Bedrossian, Edward H.; Eagle, Ralph C.; Laibson, Peter R.

doi:10.1001/archopht.1990.01070050048028

Cited by 25 publications

(12 citation statements)

References 18 publications

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“…Ulcerative keratitis has been reported in several prior cases of alcoholic pancreatitis with vitamin A deficiency in the developed world [3, 4, 5]. Patients with alcoholism are susceptible to vitamin A deficiency both because of erratic eating habits and because alcoholism predisposes to gastrointestinal disease that impedes absorption and utilization of vitamin A.…”

Section: Introductionmentioning

confidence: 99%

Keratitis with Kocuria palustris and Rothia mucilaginosa in Vitamin A Deficiency

Mattern

Ding²

2014

Case Rep Ophthalmol

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Purpose: To present a case of unusual corneal infection early in the course of peripheral ulcerative keratitis in a patient with severe vitamin A deficiency. Method: Single observational case report in urban USA. Case Presentation: An alcoholic patient with pancreatitis, chronic diarrhea, and vitamin A deficiency presented with a marginal corneal ulcer from which two bacteria of the family Micrococcaceae were cultured and identified by genome sequence analysis, namely Kocuria palustris and Rothia mucilaginosa. Soon after, severe bilateral peripheral ulcerative keratitis developed, later accompanied by eyelid cellulitis of one lid. These conditions improved with antibiotics, treatment of the underlying gastrointestinal conditions, and treatment of the vitamin deficiency. Conclusion: Susceptibility to keratitis with unusual bacteria of the Micrococcaceae family can occur in the setting of alcoholism-related gastrointestinal disease with severe vitamin A deficiency. To our knowledge, K. palustris is a species not previously identified in any human disease, and the Kocuria genus has not previously been reported as a participant in eye infection. Documented cases of R. mucilaginosa in ocular disease are rare. These unusual infections heralded the onset of severe marginal corneal melts.

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Section: Introductionmentioning

confidence: 99%

Keratitis with Kocuria palustris and Rothia mucilaginosa in Vitamin A Deficiency

Mattern

Ding²

2014

Case Rep Ophthalmol

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“…To our knowledge, there is only one prior report in which an enucleation specimen was obtained from a living patient with keratomalacia. 7 Fulminant anterior segment pathology with severe corneal xerosis, stromal melt, and perforation was observed in the specimen from our patient, whereas the posterior segment did not demonstrate outer retinal thinning that would be suggestive of permanent photoreceptor degeneration.…”

Section: Discussionmentioning

confidence: 52%

Keratomalacia in a Patient With Psychogenic Vitamin A Deficiency

Gospe

Todorich²,

Foster

et al. 2016

Cornea

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“…The lack o f conjunctival mucus-secreting cells at the lev el of the lesion in our patient caused a severe alteration of the lachrymal film, which in turn favored the metaplasia process of the epithelia and the further loss of mucus-secret ing cells [5][6][7]. We attempted a conservative therapeutic ap proach using a commercially available vitamin A (25,000 lU/lOOg) ophthalmic ointment.…”

Section: Commentmentioning

confidence: 83%