Coronary artery aneurysms

Befeler, Benjamin; Aranda, Juan M.; Embí, Abrahám A.; Mullin, Francis L.; El‐Sherif, Nabil; Lazzara, Ralph

doi:10.1016/0002-9343(77)90423-5

Cited by 224 publications

(38 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The etiologies of coronary artery aneurysms are various and have been extensively debated [2, 4, 7, 8, 9, 10]. The most common etiology of coronary aneurysm is atherosclerosis, accounting for over 50% of coronary aneurysms diagnosed in adults [1, 3, 7, 10].…”

Section: Discussionmentioning

confidence: 99%

“…Atherosclerotic coronary aneurysms, like inflammatory coronary aneurysms, are usually multiple, involve more than one coronary artery, and appear later in life than those of a congenital or inflammatory nature [1]. Atherosclerotic coronary aneurysms were found to be predominant in men [2, 7, 8, 10, 18], occur more frequently in the RCA [7, 8, 10], and often involve the multi-coronary artery tree [7, 10]. These unique clinical and angiographic findings were also found in our patients.…”

Section: Discussionmentioning

confidence: 99%

“…Although some authors have suggested that the essential component in the formation of coronary aneurysm is an abnormal vessel media which may be secondary to an extension of the intimal atherosclerotic process [2, 8, 19], the exact mechanism causing coronary aneurysms is still unknown. There is also no suggested mechanism to explain why coronary aneurysms predominantly occur in the RCA and less often involve the LMCA.…”

Section: Discussionmentioning

confidence: 99%

“…Although it has many causes, the exact mechanisms causing formation of a coronary aneurysm are still unclear [6, 7, 8, 9, 10]. Furthermore, clinical observations have demonstrated that thrombosis, embolization, and rupture of the involved segments are the leading causes of acute myocardial infarction (AMI) and sudden death from this disease entity [1, 2, 4, 5, 7, 10].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical Features and Outcome of Coronary Artery Aneurysm in Patients with Acute Myocardial Infarction Undergoing a Primary Percutaneous Coronary Intervention

Yip

Chen

et al. 2002

Cardiology

View full text Add to dashboard Cite

Background: While coronary artery aneurysm is an uncommon anatomic disorder and has various forms, its clinical features and outcome and its impact on thrombus formation and the no-reflow phenomenon in the clinical setting of acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (p-PCI) have not been discussed. The purpose of this study was to evaluate whether this anatomic disorder predisposes to a high burden of thrombus formation, and subsequently leads to the no-reflow phenomenon and untoward clinical outcome in patients with AMI undergoing p-PCI. Methods and Results: In our hospital, emergency p-PCI was performed in 924 consecutive patients with AMI between May 1993 and July 2001. Of these 924 patients, 24 patients (2.6%) who had an infarct-related artery (IRA) with aneurysmal dilatation were retrospectively registered and constituted the patient population of this study. Angiographic findings demonstrated that the ectasia type (defined as diffuse dilatation of 50% or more of the length of the IRA) was found most frequently (70%), followed by the fusiform type (20%; defined as a spindle-shaped dilatation in the IRA) and the saccular type (10%; defined as a localized spherical-shaped dilatation in the IRA). The right coronary artery was the most frequently involved vessel (54.2%), followed by the left anterior descending (25.0%) and the left circumflex arteries (20.8%). Coronary angiography revealed that all of these aneurysmal IRA filled with heavy thrombus (indicated as high-burden thrombus formation). The no-reflow phenomenon (defined as ≤TIMI-2 flow) and distal embolization after p-PCI were found in 62.5 and 70.8% of the IRA, respectively. The incidence of cardiogenic shock and the 30-day mortality rate were 25 and 8.3%, respectively. The survival rate was 90.9% (20/22) during a mean follow-up of 19 ± 30 months. Conclusions: While aneurysmal dilatation of an IRA is an uncommon angiographic finding in the clinical setting of AMI, it is frequently associated with high-burden thrombus formation and has a significantly lower incidence of successful reperfusion. However, the long-term survival of these patients is excellent.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Features and Outcome of Coronary Artery Aneurysm in Patients with Acute Myocardial Infarction Undergoing a Primary Percutaneous Coronary Intervention

Yip

Chen

et al. 2002

Cardiology

View full text Add to dashboard Cite

show abstract

“…The underlying pathological mechanism of CAE is not completely known. At the present time, CAE is considered to be a variant of CAD, although that 20-30% of cases are associated with collagenosis (16,17) or connective tissue diseases (18,19). CAE is commonly coexistent with CAD and there is a relationship between coronary ectasia and several markers of atherosclerosis and inflammation such as leukocyte counts, matrix metalloproteinases, interleukins, uric acid, adiponectin, lipoprotein-associated phospholipase A2, C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1) (20)(21)(22)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study

Kırış¹,

Bostan²,

Korkmaz³

et al. 2012

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: Carotid-femoral pulse wave velocity (PWV), the current "gold-standard" measure of arterial stiffness, has emerged as an important independent predictor of cardiovascular events. The increased PWV is recognized as an indicator of atherosclerosis. The relationship between isolated coronary artery ectasia (CAE) and carotid-femoral PWV has not been well-described. The aim of our study was to assess this relation. Methods: Thirty-four patients with isolated CAE without any visible coronary stenosis and 24 control subjects with angiographically normal coronary arteries were enrolled to this cross-sectional observational study. Applanation tonometry was applied to assess the carotid-femoral PWV. Statistical analyses were performed by Mann-Whitney U and Chi-square tests. Multiple linear regression analysis was used for the evaluation of the relations of parameters. Results: The baseline clinical and laboratory parameters of the both groups were similar. Patients with isolated CAE had significantly higher carotid-femoral PWV compared to control subjects (10.5±2.4 vs 9.2±1.7 m/s, p=0.02). In multiple regression analysis, age (beta=0.23, 95% CI=0.001-0.094, p=0.04), number of ectatic vessels (beta=0.24, 95% CI=0.044-1.07, p=0.03), and systolic blood pressure (beta=0.52, 95% CI=0.028-0.1, p=0.001) were found independently related to PWV. Conclusion: We have shown an association between increased carotid-femoral PWV and isolated CAE, suggesting that atherosclerosis may be involved in the pathogenesis of isolated CAE without any coronary stenosis in the adult population. (

show abstract

Coronary Artery Ectasia Associated With Hereditary Hemorrhagic Telangiectasia

Kurnik

Heymann²

1989

Arch Intern Med

View full text Add to dashboard Cite

Coronary artery aneurysms

Cited by 224 publications

References 44 publications

Clinical Features and Outcome of Coronary Artery Aneurysm in Patients with Acute Myocardial Infarction Undergoing a Primary Percutaneous Coronary Intervention

Clinical Features and Outcome of Coronary Artery Aneurysm in Patients with Acute Myocardial Infarction Undergoing a Primary Percutaneous Coronary Intervention

Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study

Coronary Artery Ectasia Associated With Hereditary Hemorrhagic Telangiectasia

Contact Info

Product

Resources

About