Coronary Artery Disease in Patients with Arteriosclerosis Obliterans of the Lower Extremities or Aortic Aneurysm.

Aoshima, Shinichi; Bang, Hong Rong; Masuda, Naomichi; Tawarahara, Kei; Taguchi, Takahisa; Terada, Hajime; Kaneko, Masanori; Kurata, Chinori; Kobayashi, Akira; Yamazaki, Noboru; Hachiya, Takashi; Koyano, Kenichi; Sakaguchi, Shukichi

doi:10.2169/internalmedicine.31.994

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…and pertinent information including year the case series was published, number of patients, gender, age, cardiac risk factors, peripheral vascular territory involved, and coronary angiographic data were collected and tabulated (Table 4). The 19 case series included patients undergoing elective surgery for abdominal aortic aneurysms 4,7,9,10,15,17,18,20,21,23 , lower extremity arterial lesions 12 , a combination of abdominal aortic aneurysm and lower extremity arterial lesions 8,11,22 , a combination of abdominal and thoracic aortic aneurysms 16 , carotid artery disease 5,14 , a combination of abdominal aortic aneurysm and aortoiliac disease 19 , and a combination of all territories including other areas such as renal and mesenteric arterial disease 13 (Table 4). Except for one series 4 that reported a predominance of women similar to ours, the vast majority of patients in the remaining 19 case series were men.…”

Section: Resultsmentioning

confidence: 99%

Frequency of Coronary Artery Disease in Patients Undergoing Peripheral Artery Disease Surgery

Hur

Kızılgül

Aung

et al. 2012

The American Journal of Cardiology

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The prevalence of coronary artery disease (CAD) in patients with peripheral arterial disease (PAD) varies widely in published reports. This is likely due, at least in part, to significant differences in how PAD and CAD were both defined and diagnosed. We describe 78 patients with PAD who underwent pre-operative coronary angiography prior to elective peripheral revascularization and provide a review of published case series. In our patients the number with concomitant CAD varied from 55% in those with lower extremity stenoses to as high as 80% in those with carotid artery disease. The number of coronary arteries narrowed by ≥50% in our patients was 1 in 28%, 2 in 24% and 3 in 19%; 28% did not have any angiographic evidence of CAD. Our review of the literature resulted in identification of 19 case series in which a total of 3969 patients underwent pre-operative coronary angiography prior to elective PAD surgery; in the 2687 that were described according to the location of the PAD, 55% had at least one epicardial coronary artery with ≥70% diameter narrowing. The highest prevalence of concomitant CAD was in patients with severe carotid artery disease (64%). In conclusion, despite sharing similar risk factors the prevalence of obstructive CAD in patients with PAD ranges widely, and appears to differ across PAD locations. Thus, the decision to perform coronary angiography should be based on indications independent of the planned PAD surgery.

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Section: Resultsmentioning

confidence: 99%

Frequency of Coronary Artery Disease in Patients Undergoing Peripheral Artery Disease Surgery

Hur

Kızılgül

Aung

et al. 2012

The American Journal of Cardiology

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“…Lower extremity arteriosclerosis obliterans (LEASO) is a chronic progressive disease, in which atherosclerosis causes thickening of the intima of lower extremity arteries, narrowing or even occlusion of the lumen, and further causes a series of symptoms and signs of the affected limb, such as intermittent claudication, resting pain and even ulcer necrosis (Gao et al, 2010). It was reported that the proportion of LEASO complicated with coronary artery disease was significantly higher than that of other diseases, as high as 70% (Aoshima et al, 1992). Atherosclerosis, especially LEASO, is a complex inflammatory disease process that is the major underlying cause of coronary artery disease (Seibert et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Expression and clinical significance of HSP27 and its phosphorylation in lower extremity arteriosclerosis obliterans

Bai

Wang

et al. 2020

PeerJ

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Objectives This study set out to analyze the difference of heat shock protein 27 (HSP27) and its phosphorylation in patients with lower extremity arteriosclerosis obliterans (LEASO) at different stages. This research also examined their clinical significance in this disease. Methods Blood samples from 60 patients with LEASO were collected and divided into two groups according to ankle-brachial index (ABI): group A (ABI ≤ 0.43) and group B (ABI > 0.43). The expression of HSP27 in each stage of Fontaine was measured by ELISA, and the difference of HSP27 concentration and ABI between the two groups was analyzed. Meanwhile, three normal femoral artery specimens (normal group) and three atherosclerotic femoral artery specimens (lesion group) were collected, and HSP27 and its Phospho-HSP27 (Ser15), Phospho-HSP27 (Ser78) and Phospho-HSP27 (Ser82) were detected by western blotting. The data of the protein level between the normal group and the lesion group was made a statistical analysis. Results HSP27 concentration in group A was (40.73 ± 15.99) ng/ml, and ABI was 0.26 ± 0.20. HSP27 concentration in group B was (66.30 ± 24.70) ng/ml, and ABI was 0.64 ± 0.20. The protein expression of HSP27 and its phosphorylation in the normal group was 0.82 ± 0.13, 0.66 ± 0.12, 0.91 ± 0.24 and 0.90 ± 0.16, respectively; the protein expression of the lesion group was 0.45 ± 0.08, 0.42 ± 0.09, 0.39 ± 0.12 and 0.58 ± 0.11. Conclusion Patients with higher LEASO Fontaine stage and lower ABI had a lower HSP27 concentration. Serum HSP27 concentration was negatively correlated with the severity of LEASO, while HSP27 concentration was positively correlated with ABI value. The content of HSP27 and its phosphorylation of lesion group is significantly lower than that of normal group, which may be closely related to the occurrence and development of atherosclerosis.

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Clinical, Electrocardiographic, and Echocardiographic Features in Patients with Asymptomatic Aortic Abdominal Aneurysm

et al. 1996

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Cardiac involvement in peripheral vascular diseases can present interesting patho-physiological aspects and can influence the prognosis. The authors evaluated the cardiac condition of patients with asymptomatic aortic abdominal aneurysm (AAAA) by using clinical, electrocardiographic, and echocardiographic techniques. Seventy-eight patients were studied, 74 men and 4 women, with ages ranging from fifty-five to eighty-one years (mean 69.5 +/- 6.4). All patients were submitted to a complete clinical examination, usual blood tests, a 12-lead resting electrocardiogram, and an echo-Doppler evaluation. Forty-eight subjects (61.5%) were affected by hypertension, 53 (67.9%) were smokers, 25 (32.1%) were alcohol abusers, 39 (50%) had a history of angina pectoris, 20 (25.6%) had had previous myocardial infarction, and 30 (38.5%) were receiving active cardiovascular treatment. All patients except 2, who had chronic atrial fibrillation, manifested sinus rhythm. Electrocardiographic signs of left ventricular (LV) hypertrophy were present in 20 cases (25.6%), intraventricular conduction disturbances in 19 (24.4%), pathological Q waves in 20 (25.6%), and primary repolarization abnormalities in 25 (32.1%). Echocardiography showed a slight increase in left atrial diameter and intraventricular septum thickness (41.5 +/- 4.3 and 12.3 +/- 2 mm respectively). A clearer increase was found in LV mass index (159 +/- 44 g/m2). In 31 patients one or more LV asynergic segments were found. In our patients with AAAA the prevalence of major risk factors for atherosclerosis and ischemic heart disease including previous myocardial infarction was high. Echo-derived LV myocardial mass index was higher than normal even though electrocardiographic criteria for LV hypertrophy did not match echocardiographic data in all subjects. Finally a moderate prevalence of intraventricular conduction disturbances was recorded.

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Coronary Artery Disease in Patients with Arteriosclerosis Obliterans of the Lower Extremities or Aortic Aneurysm.

Cited by 6 publications

References 6 publications

Frequency of Coronary Artery Disease in Patients Undergoing Peripheral Artery Disease Surgery

Frequency of Coronary Artery Disease in Patients Undergoing Peripheral Artery Disease Surgery

Expression and clinical significance of HSP27 and its phosphorylation in lower extremity arteriosclerosis obliterans

Clinical, Electrocardiographic, and Echocardiographic Features in Patients with Asymptomatic Aortic Abdominal Aneurysm

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