Coronary calcification in hemodialysis patients: The contribution of traditional and uremia-related risk factors

Abstract

Coronary artery calcification is highly prevalent in the hemodialysis population and is associated with older age, higher BMI, inflammation and reduced trabecular bone volume. Higher OPG is independently associated with coronary artery calcification and may represent an incomplete self-defensive response to the progression of atherosclerosis in hemodialysis patients.

Thirty-Month Follow-Up of Coronary Artery Calcification in Hemodialysis Patients: Different Roles for Inflammation and Abnormal Calcium-Phosphorous Metabolism?

“…[6,12,15] A positive correlation between CRP and DCAC was detected, as in other studies. [13,15,17] Finally, a positive correlation between DCAC and CAC score at the beginning of the study was found, which is in accordance with the observed persistent CAC score progression. Multivariate analysis applied selectively in patients with positive DCAC in the end of the study (n=27) showed that DCAC was affected mainly by CAC0 and CaxP.…”

“…This continuous CAC progression is in accordance with the findings of previous studies. [5,6,[10][11][12][13][14][15][16][17] CAC progression (DCAC) was not affected by a history of hypertension. Univariate analysis revealed that DCAC was not correlated with the amount of essential calcium intake administered as calcium bicarbonate during the study period, which is in disagreement with the results of other studies.…”

“…Age, dialysis duration, lipid profile, hypertension, abnormal calciumphosphorous metabolism, the amount of elemental calcium intake administered as calcium carbonate, and inflammation all have been associated in different studies with CAC progression in HD patients. [5,6,[10][11][12][13][14][15][16][17] The aim of the present study was to evaluate the significance of all of the above factors in CAC score progression during a 30-month period in HD patients. CAC score was assessed by repeating every six months conventional computed tomography (CCT).…”

Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy

“…Additional biopsies were selected from previous clinical studies representing 10 CKD and 10 hemodialysis (HD) patients in which five of each category were diagnosed with HTO or LTO bone disease (Table 1). (36)(37)(38) CKD biopsies were from individuals with 24-hour creatinine clearance rates between 15 and 90 mL/m 2 who had not received phosphate binders, vitamin D analogues, or corticosteroids. (36) HD patients (stage 5) were 18 years or older, and had been on hemodialysis three times weekly for at least 3 months.…”

“…(36) HD patients (stage 5) were 18 years or older, and had been on hemodialysis three times weekly for at least 3 months. (37) The technique for immunohistochemical detection of bone proteins from clinical samples was adapted from a previously reported method. (39) In brief, two adjacent 5-mm sections of bone tissue were placed side by side on each slide.…”