Coronary heart disease mortality among Arab and Jewish residents of Jerusalem

Kark, Jeremy D.; Gordon, Ethel-Sherry; Haklai, Ziona

doi:10.1016/s0140-6736(00)02849-x

Cited by 34 publications

(23 citation statements)

References 2 publications

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“…This population is known to have high rates of cardiovascular risk factors [37] ; however, we did not find any relationship between MCI/AD and cardiovascular risk factors other than hypertension. This may be partly explained by the study methodology.…”

Section: Discussioncontrasting

confidence: 90%

Hypertension Increases the Probability of Alzheimer’s Disease and of Mild Cognitive Impairment in an Arab Community in Northern Israel

et al. 2009

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Background: We aimed to determine whether vascular risk factors are associated with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) in an elderly Arab population. Methods: An Arabic-speaking team performed a door-to-door survey of consecutive residents aged ≧65 years. We estimated the odds of AD or MCI versus normal controls as a function of age, gender, education and presence of vascular factors by multinomial logistic regression with interactions. Results: Out of 767 subjects (54% men), 444 were cognitively normal, 234 had MCI and 89 had AD. AD was significantly associated with hypertension (p = 0.01; OR = 2.08; 95% CI: 1.18–3.65), age (p < 0.0001; OR = 1.19; 95% CI: 1.14–1.24), female gender (p = 0.0016; OR = 3.06; 95% CI: 1.53–6.15) and education (p = 0.0002; OR = 0.75; 95% CI: 0.65–0.88). MCI was significantly associated with hypertension (p = 0.0042; OR = 1.69; 95% CI: 1.25–2.44), age (p < 0.0001; OR = 1.06; 95% CI: 1.03–1.09) and education (p < 0.0001; OR = 0.76; 95% CI: 0.71–0.83), but not with gender. Conclusions: Hypertension, older age and low education significantly increase the probability of AD and MCI. The effect of hypertension on the odds of AD versus controls is over and above the effects of age, gender and education. For MCI versus controls there is no gender effect, and the effect of hypertension is over and above the effects of age and education.

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Section: Discussioncontrasting

confidence: 90%

Hypertension Increases the Probability of Alzheimer’s Disease and of Mild Cognitive Impairment in an Arab Community in Northern Israel

et al. 2009

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“…As diff erent religious and cultural backgrounds might be associated with various health behaviors and outcomes, we assumed that the two communities might show diff erences in health status. Such diff erences have been described in several similar contexts in other cultures such as Arab and Jewish populations 7,8 . Th ere are no studies that examined diff erences in epidemiological parameters based on ethnic relocation in the area of former Yugoslavia.…”

Section: Introductionsupporting

confidence: 64%

“…Th is is the fi rst report comparing these two entities for health outcomes twenty years after the division. Diff erences in health outcomes between the cultural and ethnic groups that inhabit the same territory have been previously described in other populations 7,8 . Both populations are Caucasian of mainly Slavic ancestry 14 , and genetic diff erences associated with recorded diff erences are not plausible, but cannot be completely excluded either.…”

Section: Resultsmentioning

confidence: 56%

Socio-Cultural Effects on Mental Health and Common Chronic Diseases in Primary Care Patients in East and West Mostar, Bosnia and Herzegovina: Preliminary Results

Vasilj

Margetić

et al. 2016

ACC

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SUMMARY -Since war activities, the previously mixed population of Mostar, Bosnia and Herzegovina, live in segregated parts of the town based on ethnicity. Th e aim of this study was to examine diff erences in health risks and health status between populations of the two parts of the town. Health status of 300 randomly selected primary care patients was evaluated by practicing family physicians in two main primary care centers in West and East Mostar. Each group consisted of 150 patients. Data were collected between December 2013 and May 2014. Patients were evaluated for smoking habit, alcohol consumption, body mass index, blood pressure and laboratory measurement of fasting glycemia. Family physicians provided diagnosis of chronic noninfectious diseases (hypertension, diabetes mellitus, cardiovascular disease, malignant disease, depression, and alcoholism). Th e two groups diff ered according to age, income, employment status, and rate of alcoholism and hypertension. Alcoholism (OR= 4.105; 95% CI 2.012-8.374) and hypertension (OR=1.972; 95% CI 1.253-3.976) were associated with inhabitants of West Mostar, adjusted for age, employment and income status on logistic regression. In conclusion, ethnic diff erences between inhabitants of the two parts of the town might infl uence health outcomes. Th ese are preliminary data and additional studies with larger samples and more specifi c questions considering nutrition and cultural issues are needed to detect the potential diff erences between the groups.

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“…19 The unique genetics that each of these three populations has adopted during the course of history has been shown in previous genetic studies, 19,22 and may be demonstrated via the disparity in prevalence of a range of diseases, such as colorectal cancer, 23 IDDM, 24 asthma 25 and coronary heart disease. 26 It should be noted that the above-mentioned populations share genomic similarities and were shown to be separated by a rather short genetic distance, especially when compared to Europeans or even to other more distant Jewish groups. 27,28 This unique relationship between Israeli populations creates a background suitable for detection of genomic variations in defined regions.…”

Section: Introductionmentioning

confidence: 99%

Genomic profiling of interpopulation diversity guides prioritization of candidate-genes for autoimmunity

et al. 2004

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Autoimmune diseases seem to have strong genetic attributes, and are affected to some extent by shared susceptibility loci. The latter potentially amount to hundreds of candidate genes (CG), creating the need for a prioritization strategy in genetic association studies. To form such a strategy, 26 autoimmune-related CG were genotyped for a total of 72 single nucleotide polymorphisms (SNPs) in three distinct Israeli ethnic populations: Ashkenazi Jews, Sephardic Jews and Arabs. Four quantitative criteria reflecting population stratification were analyzed: allele frequencies, haplotype frequencies, the F st statistic for homozygotes distribution and linkage disequilibrium extents. According to the consequent interpopulation genomic diversity profiles, the genes were classified into conserved, intermediate and diversified gene groups. Our results demonstrate a correlation between the biological role of autoimmune-related CG and their interpopulation diversity profiles as classified by the different analyses. Annotation analysis suggests that genes more readily influenced by environmental conditions, such as immunological mediators, are 'population specific'. Conversely, genes showing genetic conservation across all populations are characterized by apoptotic and cleaving functions. We suggest a research strategy by which CG association studies should focus first on likely conserved gene categories, to increase the likelihood of attaining significant results and promote the development of gene-based therapies.

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Coronary heart disease mortality among Arab and Jewish residents of Jerusalem

Cited by 34 publications

References 2 publications

Hypertension Increases the Probability of Alzheimer’s Disease and of Mild Cognitive Impairment in an Arab Community in Northern Israel

Hypertension Increases the Probability of Alzheimer’s Disease and of Mild Cognitive Impairment in an Arab Community in Northern Israel

Socio-Cultural Effects on Mental Health and Common Chronic Diseases in Primary Care Patients in East and West Mostar, Bosnia and Herzegovina: Preliminary Results

Genomic profiling of interpopulation diversity guides prioritization of candidate-genes for autoimmunity

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