Coronary Heart Disease Risks and Lifestyle Behaviors in Persons With HIV Infection

Salyer, Jeanne; Lyon, Debra E.; Settle, Jane; Elswick, R. K.; Rackley, Dwight

doi:10.1016/j.jana.2006.03.001

Cited by 16 publications

(17 citation statements)

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“…MetS was seen between the two groups (ATP III, 15.2 vs. 11.5%; IDF, 21.1 vs. 22.6%). This study shows that HIV-1 subtype C is associated with dyslipidemia, but not with a higher incidence of MetS in never antiretroviral-treated HIV-infected Africans.…”

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confidence: 89%

“…The above metabolic abnormalities are among the most significant side effects experienced with highly active antiretroviral (ARV) therapy, in particular with protease inhibitors [10,14,21]. On the other hand, the long term effects of the infection itself (as ARV therapy can not completely eradicate HIV-1) have become increasingly challenging [22] and may play a role in these metabolic changes. This is seen in the study of Bonfanti et al [23] where the prevalence of the MetS was higher in the HIV-infected individuals compared to the general population, but was similar in treated and untreated HIV-infected individuals.…”

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confidence: 99%

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Lipid Abnormalities in a Never‐Treated HIV‐1 Subtype C‐Infected African Population

Fourie

Rooyen

Kruger

et al. 2009

Lipids

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Dyslipidemia has been documented worldwide among human immunodeficiency virus-infected (HIV) individuals and these changes are reminiscent of the metabolic syndrome (MetS). In South Africa, with the highest number of HIV infections worldwide, HIV-1 subtype C is prevalent, while HIV-1 subtype B (genetically different from C) prevails in Europe and the United States. We aimed to evaluate if HIV infection (subtype C) is associated with dyslipidemia, inflammation and the occurrence of the MetS in Africans. Three hundred newly diagnosed HIV-infected participants were compared to 300 age, gender, body mass index and locality matched uninfected controls. MetS was defined according to the Adult Treatment Panel III (ATP III) and International Diabetes Federation (IDF) criteria. The HIV-infected group showed lower high density lipoprotein cholesterol (1.23 vs. 1.70 mmol/L) and low density lipoprotein cholesterol (2.60 vs. 2.80 mmol/L) and higher triglycerides (1.29 vs. 1.15 mmol/L), C-reactive protein (3.31 vs. 2.13 mg/L) and interleukin 6 (4.70 vs. 3.72 pg/L) levels compared to the uninfected group. No difference in the prevalence of the MetS was seen between the two groups (ATP III, 15.2 vs. 11.5%; IDF, 21.1 vs. 22.6%). This study shows that HIV-1 subtype C is associated with dyslipidemia, but not with a higher incidence of MetS in never antiretroviral-treated HIV-infected Africans.

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confidence: 89%

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confidence: 99%

Lipid Abnormalities in a Never‐Treated HIV‐1 Subtype C‐Infected African Population

Fourie

Rooyen

Kruger

et al. 2009

Lipids

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“…HIV infection, both before and after the introduction of PI-ART, is associated with a pro-atherogenic lipid profile characterized by an increase in triglyceride levels, a decrease in HDL-C, and the presence of small LDL-C particles (Riddler et al, 2003;Salyer, Lyon, Settle, Elswick, & Rackley, 2006). Patients on ART for six years had decreased HDL-C and BMI and increased TG and insulin values as compared to HIV-negative healthy controls (Hansen et al, 2006).…”

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confidence: 99%

Lipoatrophy of the Footpad in HIV-Treated Patients Is Associated With Increased PAI-1

Schönnesson

Bratt

2009

Biological Research For Nursing

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This is the unspecified version of the paper.This version of the publication may differ from the final published version. We would also like to thank Bernt Hildingsson Lund for coordinating the data collection and the nurses and physicians at Venhälsan, Stockholm South General Hospital for their assistance. Finally, we would like to acknowledge the assistance of the patients who gave time and effort to respond to the questionnaire and volunteered for the physical examination and blood donation. Results: Plantar pedis lipoatrophy occurred more often among ART patients (60%) than among treatment naïve patients (12%; p <0.001). ART patients with plantar lipoatrophy were older, had higher PAI-1 values, a higher prevalence of lipoatrophy in other body compartments, and longer stavudine and didanosine treatment history as compared to patients without plantar lipoatrophy. In multiple logistic regression, the best predictive model for plantar lipoatrophy was increased PAI-1 when HIV and metabolic/cardiovascular risk parameters were studied and treatment with didanosine when treatment history was studied. Permanent repository linkIncreased PAI-1 was not associated to lioatrophy in any other location.Conclusions: Plantar lipoatrophy is common among patients on long-term ART and, although often overlooked, may cause significant discomfort. The association to PAI-1, a well known marker of increased cardiovascular risk, is intriguing and further focuses on the need of an active approach to evaluating and lowering cardiovascular risk factors in long-term HIV treatment.

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“…Em outro estudo, Salyer et al 28 avaliaram os hábitos de vida de indivíduos com HIV/Aids e também identificaram alto nível de fatores de risco cardiovascular modificáveis, tais como sedentarismo e tabagismo.…”

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Risco cardiovascular: marcadores antropométricos, clínicos e dietéticos em indivíduos infectados pelo vírus HIV

Leite

Sampaio

2011

Rev. Nutr.

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Descrever marcadores antropométricos, clínicos e dietéticos associados ao risco cardiovascular em indivíduos infectados pelo vírus HIV. MétodosRealizou-se um estudo transversal com 100 indivíduos, adultos, com HIV/Aids, da cidade do Rio de Janeiro. O risco cardiovascular foi estimado pelo escore de risco de Framingham. O consumo alimentar foi avaliado por meio de um recordatório de 24 horas e de uma lista de frequência de consumo de alimentos. Para comparar variáveis, foram utilizados o teste t de Student e o teste Qui-quadrado. ResultadosDentre os indivíduos avaliados, 63% eram homens, com idade média de 41,8, DP=9,6 anos, 77% faziam uso de antirretrovirais. Escore de risco de Framingham >10% foi identificado em 53% dos indivíduos. Os principais fatores de risco cardiovascular potencialmente modificáveis identificados foram: lipoproteína de alta densidade baixo (70%), hipercolesterolemia (35%), hipertensão arterial (35%), seguidos de tabagismo (23%) e glicose alta (21%). Indivíduos com escore de risco de Framingham >10% apresentavam uma tendência para consumir dietas mais ricas em colesterol (p=0,720), em sódio (p=0,898), em açúcares/doces (p=0,032) e pobres em fibras (p=0,273), associadas a um maior consumo de bebidas alcoólicas (p=0,053). A avaliação dos hábitos de vida revelou maior prevalência de tabagismo e maior nível de sedentarismo no grupo com escore de risco de Framingham >10, porém não significativos.

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Coronary Heart Disease Risks and Lifestyle Behaviors in Persons With HIV Infection

Cited by 16 publications

References 36 publications

Lipid Abnormalities in a Never‐Treated HIV‐1 Subtype C‐Infected African Population

Lipid Abnormalities in a Never‐Treated HIV‐1 Subtype C‐Infected African Population

Lipoatrophy of the Footpad in HIV-Treated Patients Is Associated With Increased PAI-1

Risco cardiovascular: marcadores antropométricos, clínicos e dietéticos em indivíduos infectados pelo vírus HIV

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