Coronary Plaque Microstructure and Composition Modify Optical Polarization

Villiger, Martin; Otsuka, Kenichiro; Καρανάσος, Αντώνιος; Doradla, Pallavi; Ren, Jian; Lippok, Norman; Shishkov, Milen; Daemen, Joost; Diletti, Roberto; Geuns, Robert‐Jan van; Zijlstra, Felix; Soest, Gijs van; Libby, Peter; Regar, Evelyn; Nadkarni, Seemantini K.; Bouma, Brett E.

doi:10.1016/j.jcmg.2017.09.023

Cited by 61 publications

(39 citation statements)

References 28 publications

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“…This characteristic property has enabled automated segmentation of pathologic features such as drusen and atrophic zones, and has allowed the assessment of age‐related macular degeneration (AMD) . Depolarization measured with OCT has also been used to monitor the healing process and scar formation of thermal injuries in rat skin and to detect lipid‐rich areas of coronary atherosclerotic lesions and dental caries .…”

Section: Introductionmentioning

confidence: 99%

Quantitative depolarization measurements for fiber‐based polarization‐sensitive optical frequency domain imaging of the retinal pigment epithelium

Lippok

Braaf

Villiger

et al. 2018

Journal of Biophotonics

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A full quantitative evaluation of the depolarization of light may serve to assess concentrations of depolarizing particles in the retinal pigment epithelium and to investigate their role in retinal diseases in the human eye. Optical coherence tomography and optical frequency domain imaging use spatial incoherent averaging to compute depolarization. Depolarization depends on accurate measurements of the polarization states at the receiver but also on the polarization state incident upon and within the tissue. Neglecting this dependence can result in artifacts and renders depolarization measurements vulnerable to birefringence in the system and in the sample. In this work, we discuss the challenges associated with using a single input polarization state and traditional depolarization metrics such as the degree-of-polarization and depolarization power. We demonstrate quantitative depolarization measurements based on Jones vector synthesis and polar decomposition using fiber-based polarization-sensitive optical frequency domain imaging of the retinal pigment epithelium in a human eye.

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Section: Introductionmentioning

confidence: 99%

Quantitative depolarization measurements for fiber‐based polarization‐sensitive optical frequency domain imaging of the retinal pigment epithelium

Lippok

Braaf

Villiger

et al. 2018

Journal of Biophotonics

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“…Hence, in atherosclerotic tissues, depolarization is observed in plaque regions that are rich in lipid, cholesterol crystals, or macrophages. Depolarization evaluates this randomness in a small neighborhood around each pixel as the ratio of the depolarized signal intensity to the total signal intensity, corresponding to 1 minus the degree of polarization (34,48). Depolarization ranges from 0 for completely polarized light without any randomness to 1 for completely random polarization states.…”

Section: Working Principle Of Ivp With Ps-octmentioning

confidence: 99%

“…Birefringence and depolarization are polarization metrics that enable quantitative analysis of intrinsic optical tissue properties related to the composition of coronary plaques. In order to identify the respective tissue components that cause observable polarization effects, we compared polarization properties measured with IVP in human cadaveric coronary arteries with matching histology (34). Birefringence maps reinforce several features that are already discernible in the OCT intensity image.…”

Section: Characterization Of Plaque Microstructures With Ivpmentioning

confidence: 99%

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Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging

Otsuka

Villiger

Nadkarni

et al. 2020

Front. Cardiovasc. Med.

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Optical coherence tomography (OCT) and optical frequency domain imaging (OFDI) visualize the coronary artery wall and plaque morphology in great detail. The advent of these high-resolution intracoronary imaging modalities has propelled our understanding of coronary atherosclerosis and provided enhanced guidance for percutaneous coronary intervention. Yet, the lack of contrast between distinct tissue types and plaque compositions impedes further elucidation of the complex mechanisms that contribute to acute coronary syndrome (ACS) and hinders the prospective identification of plaques susceptible to rupture. Intravascular polarimetry with polarization-sensitive OFDI measures polarization properties of the coronary arterial wall using conventional intravascular imaging catheters. The quantitative polarization metrics display notable image contrast between several relevant coronary plaque microstructures that are difficult to identify with conventional OCT and OFDI. Tissues rich in collagen and smooth muscle cells exhibit birefringence, while lipid and macrophages cause depolarization. In this review, we describe the basic principles of intravascular polarimetry, discuss the interpretation of the polarization signatures, and outline promising avenues for future research and clinical implications.

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“…Because the birefringence is a direct property of the tissue, it can visualize tissue abnormalities more directly than the cumulative phase retardation [20]. Atherosclerotic plaques in human aorta have been visualized and quantitatively analyzed using PS-OCT [27,28].…”

Section: Introductionmentioning

confidence: 99%

Polarization-sensitive optical coherence elastography

Miyazawa

Makita

et al. 2019

Biomed. Opt. Express

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Polarization-sensitive optical coherence elastography (PS-OCE) is developed for improved tissue discrimination. It integrates Jones matrix-based PS-optical coherence tomography (PS-OCT) with compression OCE. The method simultaneously measures the OCT intensity, attenuation coefficient, birefringence, and microstructural deformation (MSD) induced by tissue compression. Ex vivo porcine aorta and esophagus tissues were investigated by PS-OCE and histological imaging. The tissue properties measured by PS-OCE are shown as cross-sectional images and a three-dimensional (3-D) depth-trajectory plot. In this trajectory plot, the average attenuation coefficient, birefringence, and MSD were computed at each depth, and the trajectory in the depth direction was plotted in a 3-D feature space of these three properties. The tissue boundaries in a histological image corresponded with the depth-trajectory inflection points. Histogram analysis and t-distributed stochastic neighbour embedding (t-SNE) visualization of the three tissue properties indicated that the PS-OCE measurements provide sufficient information to discriminate porcine esophagus tissues.

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Coronary Plaque Microstructure and Composition Modify Optical Polarization

Cited by 61 publications

References 28 publications

Quantitative depolarization measurements for fiber‐based polarization‐sensitive optical frequency domain imaging of the retinal pigment epithelium

Quantitative depolarization measurements for fiber‐based polarization‐sensitive optical frequency domain imaging of the retinal pigment epithelium

Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging

Polarization-sensitive optical coherence elastography

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