Coronary Stent Thrombosis and Mortality: Does the Relationship Stand the Test of Time?

Moukarbel, George V.

doi:10.1161/jaha.122.025341

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…[16][17][18] Stent thrombosis is a serious complication of PCI, with a mortality rate as high as 25% to 30%. [5,19,20] Therefore, the prevention of stent thrombosis is of great significance in reducing the risk of death after PCI. Many studies have shown that interventional procedures cause vascular endothelial injury, activate platelets, and lead to local platelet adhesion, aggregation, and activation, which are the mechanisms underlying stent thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of ticagrelor and clopidogrel dual antiplatelet therapy on MPVLR, MAADP, and AA inhibition rate in acute coronary syndrome patients after percutaneous coronary intervention

Gao,

Wang,

2023

Medicine

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Objective: To explore the effects of ticagrelor and clopidogrel dual antiplatelet therapy on the mean platelet volume-to-lymphocyte ratio (MPVLR), maximum amplitude of adenosine diphosphate-induced platelet-fibrin clots (MAADP), and arachidonic acid (AA) inhibition rates in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: A total of 120 patients with ACS undergoing elective PCI in our hospital between March 2020 and November 2021 were recruited. Patients were divided into 2 groups using the random number table method, with 60 patients in each group. The control group received clopidogrel + aspirin dual antiplatelet therapy, while the study group received ticagrelor + aspirin dual antiplatelet therapy. MPVLR, MAADP, and AA inhibition rates were compared between the 2 groups. Platelet activation indices, platelet micro PNA-223, and platelet gelsolin levels were measured before and 4 weeks after PCI. Changes in cardiac function indices, bleeding rates, and major adverse cardiovascular events (MACE) were compared between groups. Results: The MAADP score of the study group was lower than that of the control group 3 days after surgery (P < .05). Compared with before surgery, CD62p, CD63, miR-223, PAC-1, platelet membrane glycoprotein IIb/IIIa complex, and gelsolin levels markedly decreased in both groups 4 weeks after surgery (P < .05). The platelet activation index and platelet miR-223 and gelsolin levels were significantly lower in the study group than in the control group 4 weeks after surgery (P < .05). The overall platelet inhibition effect was significantly better in the study group than in the control group (P < .05). Compared with before surgery, the left ventricular ejection fraction and stroke volume were significantly increased, and the left ventricular end-diastolic volume and left ventricular end-diastolic diameter significantly decreased in both groups 4 weeks after surgery (P < .05). No significant differences were found between the 2 groups in terms of the incidence of bleeding events or MACE (P > .05). Conclusion: Ticagrelor is more effective than clopidogrel for platelet inhibition after PCI in patients with ACS and is worthy of clinical recommendation.

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Section: Discussionmentioning

confidence: 99%

Effect of ticagrelor and clopidogrel dual antiplatelet therapy on MPVLR, MAADP, and AA inhibition rate in acute coronary syndrome patients after percutaneous coronary intervention

Gao,

Wang,

2023

Medicine

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“…Stent thrombosis is rare with a reported incidence of ;0.5% with newer generation stents but carries a high mortality risk of 15%-50%. 80,81 By contrast, in-stent restenosis is relatively common complication of stenting with up to 17% of patients requiring target lesion revascularization at 3-year follow-up. 82 In addition, stenting is associated with higher rate of intraprocedural complications, longer procedure time, increased exposure to radiation for both operators and patients, an extended duration of dual antiplatelet therapy (DAPT), and higher economic burden compared with diagnostic coronary angiographies.…”

Section: Management Of Patient With Pementioning

confidence: 99%

Atherosclerotic Plaque Erosion: Mechanisms, Clinical Implications, and Potential Therapeutic Strategies—A Review

Bruoha,

Galli,

Sabouret

et al. 2024

Journal of Cardiovascular Pharmacology

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Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. While rupture of vulnerable plaques has been extensively studied, a distinct mechanism known as plaque erosion has gained recognition and attention in recent years. Plaque erosion, characterized by the loss of endothelial cell lining in the presence of intact fibrous cap contributes to a significant and growing proportion of acute coronary events. However, despite a heterogenous substrate underlying coronary thrombosis, treatment remains identical. This article provides an overview of atherosclerotic plaque erosion characteristics and its underlying mechanisms, highlights its clinical implications, and discusses potential therapeutic strategies.

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Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

Lee,

Sharma,

Hong

et al. 2024

Nano Res.

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Coronary Stent Thrombosis and Mortality: Does the Relationship Stand the Test of Time?

Cited by 5 publications

References 9 publications

Effect of ticagrelor and clopidogrel dual antiplatelet therapy on MPVLR, MAADP, and AA inhibition rate in acute coronary syndrome patients after percutaneous coronary intervention

Effect of ticagrelor and clopidogrel dual antiplatelet therapy on MPVLR, MAADP, and AA inhibition rate in acute coronary syndrome patients after percutaneous coronary intervention

Atherosclerotic Plaque Erosion: Mechanisms, Clinical Implications, and Potential Therapeutic Strategies—A Review

Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

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