Coronavirus Desease 2019 (COVID-19) in Children: Lessons from Pediatric Rheumatology

Каледа, М. И.; Nikishina, Irina; Федоров, Е. С.; Nasonov, E.

doi:10.47360/1995-4484-2020-469-479

Naučno-praktičeskaâ revmatologiâ

2020

DOI: 10.47360/1995-4484-2020-469-479

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Coronavirus Desease 2019 (COVID-19) in Children: Lessons from Pediatric Rheumatology

М. И. Каледа¹,

Irina Nikishina²,

Е. С. Федоров³

et al.

Abstract: The clinical presentation and outcomes of infection with the novel coronavirus (COVID-19) are characterized by exceptional variability in manifestations, which depend on many factors, one of which is the patient’s age. One of the severe life-threatening manifestations in adults is severe acute respiratory syndrome (SARS-CoV-2), in some cases accompanied by the development of multiple organ failure. During the first two to three months of the COVID-19 pandemic, the global medical community was of the opinion th… Show more

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Cited by 11 publications

References 97 publications

(107 reference statements)

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Right Internal Carotid Artery and Basilar Artery Aneurysms After New Coronavirus Infection COVID-19 in Adolescent: Clinical Case

et al. 2021

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The number of people infected with the SARS-CoV-2 virus causing COVID-19 is steadily growing around the world. Given the fact that the disease is new, it is necessary to study the characteristics of its spreading and clinical course, including pediatric population. The article presents clinical case of COVID-19 in 15-year-old child with the development of thrombosed basilar artery aneurysm that compressed the brain stem in the pons and subarachnoid hemorrhage, the development of a fusiform aneurysm of the right internal carotid artery. These pathologies were later complicated by right-sided hemiparesis. The importance of inter-clinical interaction of physicians of all specialties and the need for early rehabilitation at the outpatient stage of treatment in the context of the COVID-19 pandemic were shown.

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Right Internal Carotid Artery and Basilar Artery Aneurysms After New Coronavirus Infection COVID-19 in Adolescent: Clinical Case

et al. 2021

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Management of Children with Pericardial Effusion after COVID-19 on Outpatient Level of Service

et al. 2022

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The steady increase in the number of people infected with SARS-CoV-2 virus causing COVID-19 all over the world necessitates further study of fundamental features of pandemic spreading and clinical signs of disease, especially in children population. This article presents the experience of managing patients with pericardial effusion that has developed after new coronavirus infection COVID-19. The role of timely diagnosis of pericardial effusion, principles of its diagnostics, management, and follow-up observation on outpatient level within the pandemic are presented.

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Features of laboratory parameters in children with multisystem inflammatory syndrome associated with SARS-CoV-2

Обухова

Ryabichenko

Karpovich

et al. 2022

Sibirskij nauchnyj medicinskij zhurnal

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Multisystem inflammatory syndrome (MIS-C) is a new childhood disease associated with coronavirus SARS-CoV-2 that manifests itself 3–4 weeks after infection. The development of MIS-C is possible, despite the asymptomatic course of coronavirus infection. The pathogenetic features of MIS-C remain unclear. The aim of the study was to investigate the state of peripheral blood parameters in children with multisystem inflammatory syndrome associated with SARS-CoV-2 upon admission to a hospital. Material and methods. We examined 52 children with MIS-C from 1 to 14 years old, hospitalized in Children`s Clinical Hospital No. 3 in Novosibirsk in October–December 2020. Testing for the isolation of SARS-CoV-2 RNA in scrapings from the nasopharynx and oropharynx was carried out using real time PCR (test systems of DNA-Technology, Russia). The presence of specific IgM and IgG antibodies to SARS-CoV-2 in blood serum was determined by ELISA using Vector-Best kits (Russia). Results and discussion. It was noted that SARS-CoV-2 virus RNA was found only in 12.8 % of cases, while specific IgG antibodies in blood serum were detected in 100 % of children. IgM to SARS-CoV-2 antigens were detected in the blood serum only in 53.85 % of children with MIS-C. It has been established that unexpressed leukocytosis was found both in children under the age of 7 and in children of 8–14 years old. However, the leukocytes content in children of the older age group was significantly lower than in children aged 1–7 years. At the same time, in both age groups, some children had extremely low values of the indicator. The causes of severe leukopenia against the background of excessive inflammation remain unclear. Age groups (1–7 and 8–14 years) do not differ statistically significantly in the relative content of lymphocytes and neutrophils. In the study of individual values of the relative content of lymphocytes within the age groups, it was noted that only some children had lymphopenia of varying severity. Conclusions. Against the background of minor leukocytosis in children with MIS-C, upon admission to the hospital, there is a tendency to develop both relative and absolute lymphopenia, regardless of age. The study noted an extremely pronounced variability of individual values of the evaluated peripheral blood parameters, regardless of age, which, with similar clinical symptoms, characterized as MIS-C, requires further study in dynamics, taking into account the initial values of the indicators.There is no pronounced relationship between the leukocytes content and specific IgM antibodies to SARS-CoV-2 antigens in the blood.

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Coronavirus Desease 2019 (COVID-19) in Children: Lessons from Pediatric Rheumatology

Cited by 11 publications

References 97 publications

Right Internal Carotid Artery and Basilar Artery Aneurysms After New Coronavirus Infection COVID-19 in Adolescent: Clinical Case

Right Internal Carotid Artery and Basilar Artery Aneurysms After New Coronavirus Infection COVID-19 in Adolescent: Clinical Case

Management of Children with Pericardial Effusion after COVID-19 on Outpatient Level of Service

Features of laboratory parameters in children with multisystem inflammatory syndrome associated with SARS-CoV-2

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