Aim and objective:The novel coronavirus pandemic has resulted in telemedicine becoming a commonplace for patient care. Being a novel disease, and there are still multiple opinions and differences in all the treatment protocols and investigations followed, due to the vast amount of literature available. A consolidated review of all the literature relating to each field is needed, so that it can be accessed and used easily by upcoming treating doctors and researchers for managing coronavirus disease-2019 (COVID-19). A review of published literature was done to systemically analyze the symptoms, investigations, and treatment protocols. Study design: Systematic literature review. Materials and methods: One hundred randomized, clinical, and experimental trials were reviewed by us. These trials were conducted since the first instance of COVID-19 in December 2019. A systemic literature review was done of all the PubMed indexed journals published between January 2020 and August 2020 using keywords COVID-19, coronavirus, and otorhinolaryngology, with use of World Health Organization website for references of official manuals and protocols, published in the English language. Results: From 100 original articles screened, all were systematically categorized into clinical features, investigations, and treatment. All the clinical features were described as early and late-onset symptoms. Investigations and various methods for evaluation were described in detail. Also, specific investigations for each clinical symptom like loss of smell and taste were also described. Data was insufficient for meta-analysis. Conclusions: Preventive measures and early mitigation are essential in breaking the chain. The current review of the literature suggests the preventive measures in the community with the most efficacy include proper hand hygiene, such as washing hands frequently with soap and water or using an alcohol-based hand rub with 60% isopropyl alcohol or more, and to avoid touching the face. This may prevent the transmission of the pathogen to the respiratory tract and thereby prevent the spread of this fatal disease.