Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective

Shafiee, Abbas; Moradi, Lida; Lim, Mayasari; Brown, John J.

doi:10.1002/sctm.20-0197

Cited by 24 publications

(29 citation statements)

References 61 publications

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“…The SARS-CoV-2 disease generates pro-inflammatory cytokines and chemokines storm, which cause severe inflammation. Inflammation is the driving power that leads to coronavirus infections such as severe shock, and multiple organ failure results in acute respiratory distress syndrome[ 88 , 89 ]. Another study showed that COVID-19 patients (mild to severe) showed low serum Ca 2 + .…”

Section: Discussionmentioning

confidence: 99%

Calcium channels and their role in regenerative medicine

Ahamad

Singh

2021

WJSC

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Stem cells hold indefinite self-renewable capability that can be differentiated into all desired cell types. Based on their plasticity potential, they are divided into totipotent (morula stage cells), pluripotent (embryonic stem cells), multipotent (hematopoietic stem cells, multipotent adult progenitor stem cells, and mesenchymal stem cells [MSCs]), and unipotent (progenitor cells that differentiate into a single lineage) cells. Though bone marrow is the primary source of multipotent stem cells in adults, other tissues such as adipose tissues, placenta, amniotic fluid, umbilical cord blood, periodontal ligament, and dental pulp also harbor stem cells that can be used for regenerative therapy. In addition, induced pluripotent stem cells also exhibit fundamental properties of self-renewal and differentiation into specialized cells, and thus could be another source for regenerative medicine. Several diseases including neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, virus infection (also coronavirus disease 2019) have limited success with conventional medicine, and stem cell transplantation is assumed to be the best therapy to treat these disorders. Importantly, MSCs, are by far the best for regenerative medicine due to their limited immune modulation and adequate tissue repair. Moreover, MSCs have the potential to migrate towards the damaged area, which is regulated by various factors and signaling processes. Recent studies have shown that extracellular calcium (Ca 2+ ) promotes the proliferation of MSCs, and thus can assist in transplantation therapy. Ca 2+ signaling is a highly adaptable intracellular signal that contains several components such as cell-surface receptors, Ca 2+ channels/pumps/exchangers, Ca 2+ buffers, and Ca 2+ sensors, which together are essential for the appropriate functioning of stem cells and thus modulate their proliferative and regenerative capacity, which will be discussed in this review.

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Section: Discussionmentioning

confidence: 99%

Calcium channels and their role in regenerative medicine

Ahamad

Singh

2021

WJSC

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“…During the pandemic of the COVID-19, most scientists, including the healthcare professionals have stopped their basic research to rather fully focus on COVID-19. Moreover, various hospitals have postponed their routine clinical trials and surgical operations involving tissue replacement and reconstructive surgeries, as the hospitals and the medical staff were devoted to treating the COVID-19 patients [ 32 ]. Thus, COVID-19 has created a great imbalance in the healthcare system worldwide.…”

Section: Environmental Stressorsmentioning

confidence: 99%

The impact of oxidative stress damage induced by the environmental stressors on COVID-19

et al. 2021

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The ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a substantial stressor that is greatly impacting environmental sustainability. Besides, the different pre-existing environmental stressors and coronavirus disease-2019 (COVID-19)-related stressors are further worsening the effects of the viral disease by inducing the generation of oxidative stress. The generated oxidative stress results in nucleic acid damage associated with viral mutations, that could potentially reduce the effectiveness of COVID-19 management, including the vaccine approach. The current review is aimed to overview the impact of the oxidative stress damage induced by various environmental stressors on COVID-19. The available data regarding the COVID-19-related stressors and the effects of oxidative stress damage induced by the chronic stress, exposure to free radicals, and malnutrition are also analyzed to showcase the promising options, which could be investigated further for sustainable control of the pandemic.

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“…Toward this end, tissue engineering techniques and 3D printing in combination with microfluidics could be used to construct the organs and immune tissues, such as thymus, lung, bone marrow, spleen, lymph nodes, and their intracellular compartments, as well as infection models to study human immune function and diseases. 62,66,67 One of these engineered platforms, organ-on-a-chip technology, has allowed to recapitulate the life cycle of HBV in a 3D microfluidic primary human hepatocyte (PHH) culture. 68 Different viral infection models could be engineered similarly to study the pathophysiological characteristics of human viral infections and to test drug candidates.…”

Section: Biomaterials and Nanotechnolgymentioning

confidence: 99%

Biomaterials-based formulations and surfaces to combat viral infectious diseases

Kumari

Chatterjee

2021

APL Bioengineering

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Rapidly growing viral infections are potent risks to public health worldwide. Accessible virus-specific antiviral vaccines and drugs are therapeutically inert to emerging viruses, such as Zika, Ebola, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, discovering ways to prevent and control viral infections is among the foremost medical challenge of our time. Recently, innovative technologies are emerging that involve the development of new biomaterial-based formulations and surfaces endowed with broad-spectrum antiviral properties. Here, we review emerging biomaterials technologies for controlling viral infections. Relevant advances in biomaterials employed with nanotechnology to inactivate viruses or to inhibit virus replication and further their translation in safe and effective antiviral formulations in clinical trials are discussed. We have included antiviral approaches based on both organic and inorganic nanoparticles (NPs), which offer many advantages over molecular medicine. An insight into the development of immunomodulatory scaffolds in designing new platforms for personalized vaccines is also considered. Substantial research on natural products and herbal medicines and their potential in novel antiviral drugs are discussed. Furthermore, to control contagious viral infections, i.e., to reduce the viral load on surfaces, current strategies focusing on biomimetic anti-adhesive surfaces through nanostructured topography and hydrophobic surface modification techniques are introduced. Biomaterial surfaces functionalized with antimicrobial polymers and nanoparticles against viral infections are also discussed. We recognize the importance of research on antiviral biomaterials and present potential strategies for future directions in applying these biomaterial-based approaches to control viral infections and SARS-CoV-2.

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Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective

Cited by 24 publications

References 61 publications

Calcium channels and their role in regenerative medicine

Calcium channels and their role in regenerative medicine

The impact of oxidative stress damage induced by the environmental stressors on COVID-19

Biomaterials-based formulations and surfaces to combat viral infectious diseases

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