Coronavirus disease 2019 (COVID-19): first indication of efficacy of Gene-Eden-VIR/Novirin in SARS-CoV-2 infection

Polansky, Hanan; Lori, Gillad

doi:10.1016/j.ijantimicag.2020.105971

Cited by 42 publications

(36 citation statements)

References 9 publications

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“…Since these methods are now the "gold standard" for screening new drugs and their targets, we can hypothesize the beneficial effects of hesperidin in COVID-19 as well, pending the need of clinical evidence of therapeutic efficacy. The binding of hesperidin to the central part of the spike and to the main protease is much stronger than that of conventional antivirals, and it can be expected that this molecule may soon be tested in randomized trials of patients with COVID-19 or subjects exposed to contagion, as is the case for quercetin, or for a mix of quercetin, green tea, cinnamon and liquorice [115]. These new pharmacological properties of hesperidin are added to those of an antioxidant agent, already known.…”

Section: Discussionmentioning

confidence: 99%

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

Bellavite

Donzelli²

2020

Antioxidants

162

140

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Among the many approaches to Coronavirus disease 2019 (COVID-19) prevention, the possible role of nutrition has so far been rather underestimated. Foods are very rich in substances, with a potential beneficial effect on health, and some of these could have an antiviral action or be important in modulating the immune system and in defending cells from the oxidative stress associated with infection. This short review draws the attention on some components of citrus fruits, and especially of the orange (Citrus sinensis), well known for its vitamin and flavonoid content. Among the flavonoids, hesperidin has recently attracted the attention of researchers, because it binds to the key proteins of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several computational methods, independently applied by different researchers, showed that hesperidin has a low binding energy, both with the coronavirus “spike” protein, and with the main protease that transforms the early proteins of the virus (pp1a and ppa1b) into the complex responsible for viral replication. The binding energy of hesperidin to these important components is lower than that of lopinavir, ritonavir, and indinavir, suggesting that it could perform an effective antiviral action. Furthermore, both hesperidin and ascorbic acid counteract the cell damaging effects of the oxygen free radicals triggered by virus infection and inflammation. There is discussion about the preventive efficacy of vitamin C, at the dose achievable by the diet, but recent reviews suggest that this substance can be useful in the case of strong immune system burden caused by viral disease. Computational methods and laboratory studies support the need to undertake apposite preclinical, epidemiological, and experimental studies on the potential benefits of citrus fruit components for the prevention of infectious diseases, including COVID-19.

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Section: Discussionmentioning

confidence: 99%

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

Bellavite

Donzelli²

2020

Antioxidants

162

140

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“…Flavonoids exhibit antiviral ( Dai et al, 2019 ), antibacterial ( Yixi et al, 2015 ), antimicrobial ( Cushnie and Lamb, 2005 ), anticancer ( Chahar et al, 2011 ), antidiabetic ( AL-Ishaq et al, 2019 ), anti-inflammatory ( He et al, 2018 ) and antifungal ( Weidenbörner et al, 1990 ) properties. Recent reports show quercetin based antiviral drug Gene-Eden-VIR/Novirin inhibiting the protease of SARS-CoV-2 ( Polansky and Lori, 2020 ). Chalcones in flavonoids subset inhibit tobacco mosaic virus ( Tang et al, 2019 ), HIV ( Wu et al, 2003 ), herpes ( Hassan et al, 2015 ) and dengue virus ( Kiat et al, 2006 ) along with antioxidant ( Biradar et al, 2010 ), antimicrobial ( Burmaoglu et al, 2017 ), antimycobacterial ( Chiaradia et al, 2012 ) and antileishmanial ( de Mello et al, 2018 ) properties.…”

Section: Introductionmentioning

confidence: 99%

In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2

Vijayakumar

Ramesh

Joji

et al. 2020

European Journal of Pharmacology

110

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is distinctly infective and there is an ongoing effort to find a cure for this pandemic. Flavonoids exist in many diets as well as in traditional medicine, and their modern subset, indole-chalcones, are effective in fighting various diseases. Hence, these flavonoids and structurally similar indole chalcones derivatives were studied in silico for their pharmacokinetic properties including absorption, distribution, metabolism, excretion, toxicity (ADMET) and anti-SARS-CoV-2 properties against their proteins, namely, RNA dependent RNA polymerase (rdrp), main protease (M pro ) and Spike (S) protein via homology modelling and docking. Interactions were studied with respect to biology and function of SARS-CoV-2 proteins for activity. Functional/structural roles of amino acid residues of SARS-CoV-2 proteins and, the effect of flavonoid and indole chalcone interactions which may cause disease suppression are discussed. The results reveal that out of 23 natural flavonoids and 25 synthetic indole chalcones, 30 compounds are capable of M pro deactivation as well as potentially lowering the efficiency of M pro function. Cyanidin may inhibit RNA polymerase function and, Quercetin is found to block interaction sites on the viral spike. These results suggest flavonoids and their modern pharmaceutical cousins, indole chalcones are capable of fighting SARS-CoV-2. The in vitro anti-SARS-CoV-2 activity of these 30 compounds needs to be studied further for complete understanding and confirmation of their inhibitory potential.

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“…The licorice plant, Glycyrrhiza glabra L., was reported to have specific anti-SARS effects (Polansky and Lori 2020 ). Constituents of licorice include triterpenoids such as glycyrrhizin or glycyrrhizic acid ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Chinsembu

2020

Rev. Bras. Farmacogn.

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Current challenges to the treatment of coronavirus disease 2019 should open new prospects in the search for novel drugs from medicinal plants and other natural products. This paper provides details of natural agents that inhibit human coronavirus entry into cells, general replication, and specific chymotrypsin-like protease (3CL pro)-mediated replication. Medicinal plants, fungi, and marine organisms as remedies for human coronaviruses in China, Lebanon, Malaysia, Singapore, and South Africa are described. Common species include Alnus japonica (Thunb.

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Coronavirus disease 2019 (COVID-19): first indication of efficacy of Gene-Eden-VIR/Novirin in SARS-CoV-2 infection

Cited by 42 publications

References 9 publications

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2

Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

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