Sustainable development has always been the objective of many fields, including the tourism and transportation sector. However, a major part of this sector, the airline industry, deals with many negative impacts, such as air pollution, noise, CO2 emission, and labor practice. Corporate social responsibility (CSR) is a strategic business activity that can enhance the sustainability of the airline industry. The results of the Dow Jones Sustainability Indices (DJSI) reveal that airlines of Western countries exhibit a more remarkable CSR performance than Asia-Pacific airlines, suggesting that the CSR programs of Asia-Pacific airlines need improvement. By constructing an evaluation hierarchy and applying the decision-making trial and evaluation laboratory (DEMATEL) method, this study found that the key strategic factors in the airline industry's implementation of CSR include corporate governance, risk and crisis management, brand management, and product responsibility (safety).