PurposeThe purpose of this paper is to evaluate the interplay of various measures used by different governments around the world in combatting COVID-19.Design/methodology/approachThe research uses the interpretative structural modelling (ISM) for assessing the powerful measures amongst the recognized ones, whereas to establish the cause-and-effect relations amongst the variables, the Decision-Making Trial and Evaluation Laboratory (DEMATEL) method is used. Both approaches utilized in the study aid in the comprehension of the relationship amongst the assessed measures.FindingsAccording to the ISM model, international support measures have the most important role in reducing the risk of COVID-19. There has also been a suggestion of a relationship between economic and risk measures. Surprisingly, no linkage factor (unstable one) was reported in the research. The study indicates social welfare measures, R&D measures, centralized power and decentralized governance measures and universal healthcare measures as independent factors. The DEMATEL analysis reveals that the net causes are social welfare measures, centralized power and decentralized government, universal health coverage measure and R&D measures, while the net effects are economic measures, green recovery measures, risk measures and international support measures.Originality/valueThe study includes a list of numerous government measures deployed throughout the world to mitigate the risk of COVID-19, as well as the structural links amongst the identified government measures. The Matrice d'Impacts croises-multiplication applique and classment analysis can help the policymakers in understanding measures used in combatting COVID-19 based on their driving and dependence power. These insights may assist them in employing these measures for mitigating the risks associated with COVID-19 or any other similar pandemic situation in the future.