Corpus callosum–fastigium and tectal lengths in late‐onset small fetuses

Abstract

This study demonstrates that, relative to appropriatefor-gestational-age controls, small fetuses exhibit smaller midbrain measurements, namely corpus callosumfastigium length and tectal length, with more pronounced differences in those with fetal growth restriction. What are the clinical implications of this work?If future studies in small fetuses confirm the association of prenatal corpus callosum-fastigium and tectal lengths with neurodevelopmental outcome, these midbrain measurements could feasibly represent biomarkers for suboptimal neurodevelopment.

Does diabetes mellitus affect the development of fetal brain structures and spaces including corpus callosum, subarachnoid space, insula, and parieto‐occipital fissure?

“…The examination of prenatal brain development has been conducted by the imaging modalities of ultrasonography and magnetic resonance imaging (MRI), and using animal models in several obstetrical conditions, such as preeclampsia, growth retardation, and fetal cardiac abnormalities. [21][22][23][24] On the other hand, although the investigation of the effect of DM on fetal brain development is mainly limited to MRI 13 and animal models, 25 there have been a few studies conducted with ultrasound in recent years. 26,27 The results of existing and current research, including ultrasonographic measurements of different brain regions, suggest that DM may have a potential impact on fetal brain development.…”

Fetal corpus callosal anomalies: from disease of classification to classification of disease

“…That the anomalies of the CC represent a hot topic in fetal medicine is demonstrated by the number of articles published over the last 2 years in this Journal [26][27][28][29] . In our opinion, what is indeed important is to classify corpus callosal anomalies based only on well-developed, standardized and agreed criteria.…”

Neurosonographic evaluation of corpus callosum–fastigium and tectal length in late‐onset small fetuses

“…Thus, monitoring the neurodevelopment of small fetuses is of great importance, as it can guide necessary intervention to improve prognosis. We read recently the case-control study of Lip-Sosa et al 2 , which compared corpus callosum-fastigium length (CCFL) and tectal length (TL) between small fetuses and matched appropriate-for-gestational-age (AGA) controls. Their findings indicated that small fetuses, especially those with FGR, had markedly shorter CCFL and TL compared to AGA fetuses.…”