CORR Insights®: Is the Induced-membrane Technique Successful for Limb Reconstruction After Resecting Large Bone Tumors in Children?

Nicholas, Richard W.

doi:10.1007/s11999-015-4206-0

Cited by 2 publications

(4 citation statements)

References 9 publications

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“…Additionally, paediatric series are extremely diverse, as varied populations comprise the data (malignant tumours, congenital pathologies, chronic infections, trauma). 7 , 12 , 13 Recently, Rousset et al 29 reported the results of treatment for immature osteomyelitis. They confirmed the efficacy of IMT in treating large bone defects in young patients.…”

Section: Discussionmentioning

confidence: 99%

Radiological and clinical outcomes using induced membrane technique combined with bone marrow concentrate in the treatment of chronic osteomyelitis of immature patients

Shen

Sun

et al. 2021

Bone & Joint Research

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Aims Treatment of chronic osteomyelitis (COM) for young patients remains a challenge. Large bone deficiencies secondary to COM can be treated using induced membrane technique (IMT). However, it is unclear which type of bone graft is optimal. The goal of the study was to determine the clinical effectiveness of bone marrow concentrator modified allograft (BMCA) versus bone marrow aspirate mixed allograft (BMAA) for children with COM of long bones. Methods Between January 2013 and December 2017, 26 young patients with COM were enrolled. Different bone grafts were applied to repair bone defects secondary to IMT procedure for infection eradication. Group BMCA was administered BMCA while Group BMAA was given BMAA. The results of this case-control study were retrospectively analyzed. Results Patient infection in both groups was eradicated after IMT surgery. As for reconstruction surgery, no substantial changes in the operative period (p = 0.852), intraoperative blood loss (p = 0.573), or length of hospital stay (p = 0.362) were found between the two groups. All patients were monitored for 12 to 60 months. The median time to bone healing was 4.0 months (interquartile range (IQR) 3.0 to 5.0; range 3 to 7) and 5.0 months (IQR 4.0 to 7.0; range 3 to 10) in Groups BMCA and BMAA, respectively. The time to heal in Group BMCA versus Group BMAA was substantially lower (p = 0.024). Conclusion IMT with BMCA or BMAA may attain healing in large bone defects secondary to COM in children. The bone healing time was significantly shorter for BMCA, indicating that this could be considered as a new strategy for bone defect after COM treatment. Cite this article: Bone Joint Res 2021;10(1):31–40.

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Section: Discussionmentioning

confidence: 99%

Radiological and clinical outcomes using induced membrane technique combined with bone marrow concentrate in the treatment of chronic osteomyelitis of immature patients

Shen

Sun

et al. 2021

Bone & Joint Research

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“…The membrane is primarily composed of type I collagen, fibroblasts, and blood vessels (inner surface), and it secretes bone morphogenetic protein 2, vascular endothelial growth factor, core-binding factor α1, interleukin 6, collagenase-1, and other growth factors to stimulate bone defect reconstruction [4]. The technique has been shown to promote consolidation of cancellous bone graft within an induced membrane in segmental bone defects of up to 20-25 cm in length [1,5,6]. Despite the fact that the induced membrane technique was described in 1986 [14], its use in children has rarely been reported, unlike in adults.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the fact that the induced membrane technique was described in 1986 [14], its use in children has rarely been reported, unlike in adults. Also, pediatric series are extremely heterogeneous, as mixed populations of patients were included in these reviews (malignant tumours, congenital pathologies, chronic infections, trauma) [1,5,9].…”

Section: Discussionmentioning

confidence: 99%

“…Despite the fact that this technique was first described in 1986 [4], available data in the pediatric population are scarce. Also, most published pediatric series are heterogeneous, and include children with different pathologies [1,3,[5][6][7][8][9]. In addition, it is not clear what type of bone substitute should be used to reconstruct large bone defects following induced membrane formation [10].…”

Section: Introductionmentioning

confidence: 99%

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Chronic infection and infected non-union of the long bones in paediatric patients: preliminary results of bone versus beta-tricalcium phosphate grafting after induced membrane formation

Rousset

Walle

Cambou

et al. 2017

International Orthopaedics (SICOT)

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CORR Insights®: Is the Induced-membrane Technique Successful for Limb Reconstruction After Resecting Large Bone Tumors in Children?

Cited by 2 publications

References 9 publications

Radiological and clinical outcomes using induced membrane technique combined with bone marrow concentrate in the treatment of chronic osteomyelitis of immature patients

Radiological and clinical outcomes using induced membrane technique combined with bone marrow concentrate in the treatment of chronic osteomyelitis of immature patients

Chronic infection and infected non-union of the long bones in paediatric patients: preliminary results of bone versus beta-tricalcium phosphate grafting after induced membrane formation

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