Corrected and Republished from: “Understanding Lactobacillus paracasei and Streptococcus oralis Biofilm Interactions through Agent-Based Modeling”

Abstract

We previously discovered a role of the oral commensal Streptococcus oralis as an accessory pathogen. S. oralis increases the virulence of Candida albicans infections in murine oral candidiasis and epithelial cell models through mechanisms which promote the formation of tissue-damaging biofilms. Lactobacillus species have known inhibitory effects on biofilm formation of many microbes, including Streptococcus species. Agent-based modeling has great advantages as a means of exploring multifaceted relationships between organisms in complex environments such as biofilms.

Activating Biocake Communities Retards Jumps of Transmembrane Pressure in Membrane Bioreactors

“…For example, Candidatus_Competibacter is known as a typical glycogen-accumulating organism that can accelerate sludge floc formation by excreting extracellular PS. , Herein, Candidatus_Competibacter (9.24 vs 5.75%) presented a lower relative abundance in nutrient-enriched biocakes (M6) than low-nutrient biocakes (M1). Compared to low-nutrient biocakes (M1), nutrient-enriched biocakes (M6) contained a higher relative abundance of Lactobacillus (0.04 vs 0.02%), which was reported to have the ability to intercept the production of N -acyl-L-homoserine lactones. , …”

“…Compared to low-nutrient biocakes (M1), nutrient-enriched biocakes (M6) contained a higher relative abundance of Lactobacillus (0.04 vs 0.02%), which was reported to have the ability to intercept the production of N-acyl-L-homoserine lactones. 43,44 Using the Random Forest model (Table S7 and Figure S6), we identified a cluster of biomarker taxa that were more sensitive to fluctuations after nutrition exposure. Of the identified biomarker genera, the contents of six different genera (e.g., Streptomyces, Cloacibacterium, and Nocardia) decreased with an increase in organic concentrations and the content of one genus (i.e., Ruminococcaceae UCG.002) increased with an increase in the nutrient loading, suggesting that with nutrient exposure, most taxa were gradually depleted and only a few were enriched.…”

Modulating the skin mycobiome-bacteriome and treating seborrheic dermatitis with a probiotic-enriched oily suspension

“…This suggests that delivering probiotics in biofilm-like microcolonies could boost bacterial functionalities 44 . L. paracasei, which is known to produce molecules with antimicrobial and surfactant properties, is able to form biofilm and inhibit Streptococcus oralis growth in vitro 45 . In conjunction with other characteristics, the biofilm-forming ability makes L. crispatus and L. paracasei effective probiotics for skin health.…”