Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes

Cervera, Javier; Levin, Michael; Mafé, Salvador

doi:10.1016/j.bbagen.2023.130440

Biochimica et Biophysica Acta (BBA) - General Subjects

2023

DOI: 10.1016/j.bbagen.2023.130440

|View full text |Cite

Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes

Javier Cervera

Michael Levin

Salvador Mafé

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models

Cervera,

Levin,

Mafe

2024

Sci Rep

View full text Add to dashboard Cite

Cells can compensate a disruptive change in one ion channel by compensatory changes in other channels. We have simulated the adaptation of a multicellular aggregate of non-excitable cells to the electrophysiological perturbation produced by the external blocking of a cation channel. In the biophysical model employed, we consider that this blocking provokes a cell depolarization that opens a voltage-gated calcium channel, thus allowing toxic Ca2+ levels. The cell adaptation to this externally-induced perturbation is ascribed to the multiplicity of channels available to keep the cell membrane potential within a physiological window. We propose that the cell depolarization provokes the upregulated expression of a compensatory channel protein that resets the cell potential to the correct polarized value, which prevents the calcium entry. To this end, we use two different simulation algorithms based on deterministic and stochastic methods. The simulations suggest that because of the local correlations coupling the cell potential to transcription, short-term bioelectrical perturbations can trigger long-term biochemical adaptations to novel stressors in multicellular aggregates. Previous experimental data on planarian flatworms’ adaptation to a barium-containing environment is also discussed.

show abstract

Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models

Cervera,

Levin,

Mafe

2024

Sci Rep

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes

Cited by 1 publication

References 56 publications

Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models

Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models

Contact Info

Product

Resources

About