Correction: Characteristics of hospitalized patients during a large waterborne outbreak of Campylobacter jejuni in Norway

Mortensen, Nicolay; Jonasson, Solveig Aalstad; Lavesson, Ingrid Viola; Emberland, Knut Erik; Litleskare, Sverre; Wensaas, Knut‐Arne; Rørtveit, Guri; Langeland, Nina; Hanevik, Kurt

doi:10.1371/journal.pone.0259407

Cited by 6 publications

(2 citation statements)

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“…C. jejuni-infected humans complain about gastroenteritis with diverse clinical manifestations, ranging from mild clinical signs to severe symptoms characterized by fever, Biomolecules 2023, 13, 320 2 of 19 vomiting, abdominal cramps, and watery or even bloody diarrhea [11,12]. The symptoms usually resolve within two weeks post infection (p.i.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Oral Application of Carvacrol Alleviates Acute Campylobacteriosis in Mice Harboring a Human Gut Microbiota

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Mousavi

et al. 2023

Biomolecules

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Human Campylobacter jejuni infections are rising globally. Since antibiotics are usually not indicated in acute campylobacteriosis, antibiotic-independent intervention measures are desirable. The phenolic compound carvacrol constitutes a promising candidate molecule given its antimicrobial and immune-modulatory features. To test the disease-alleviating effects of oral carvacrol treatment in acute murine campylobacteriosis, IL-10−/− mice harboring a human gut microbiota were perorally infected with C. jejuni and treated with carvacrol via the drinking water. Whereas C. jejuni stably established in the gastrointestinal tract of mice from the placebo cohort, carvacrol treatment resulted in lower pathogen loads in the small intestines on day 6 post infection. When compared to placebo, carvacrol ameliorated pathogen-induced symptoms including bloody diarrhea that was accompanied by less distinct histopathological and apoptotic cell responses in the colon. Furthermore, innate and adaptive immune cell numbers were lower in the colon of carvacrol- versus placebo-treated mice. Notably, carvacrol application dampened C. jejuni-induced secretion of pro-inflammatory mediators in intestinal, extra-intestinal and systemic organs to naive levels and furthermore, resulted in distinct shifts in the fecal microbiota composition. In conclusion, our preclinical placebo-controlled intervention study provides evidence that therapeutic carvacrol application constitutes a promising option to alleviate campylobacteriosis in the infected vertebrate host.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Oral Application of Carvacrol Alleviates Acute Campylobacteriosis in Mice Harboring a Human Gut Microbiota

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Mousavi

et al. 2023

Biomolecules

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“…generally produces self-limiting gastroenteritis, but some complications, such as septicemia, m e n i n g i t i s , h e m o l y t i c -u r e m i c s y n d r o m e , pancreatitis, and abortion have been reported. Moreover, post-infection sequels such as reactive arthritis and Guillain Bare syndrome have been 18,20 attributed.…”

Section: Incidence Rate =mentioning

confidence: 99%

Campylobacteriosis in An Outbreak of Foodborne Disease at Bantar Gadung Village Palabuhan Ratu

Budiailmiawan¹,

Parwati²,

Rita³

et al. 2022

Indonesian J. Clin. Pathol. Med. Lab.

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Campylobacteriosis is a rare enteritis case in Indonesia. On September 12, 2019, there was an outbreak of foodborneÂ diseases with the symptoms of fever, abdominal cramps, and bloody diarrhea after eating food from the Tahlilan (funeralÂ prayer) ceremonial at Bantar Gadung village Palabuhan Ratu Sukabumi. The laboratory and epidemiological investigationwere performed. Fresh stool samples were collected from 18 suspected cases. Gram stain, routine stool examination, andÂ PCR were performed. The PCR method was used based on the nested PCR method by Platts-Mills et al. for CampylobacterÂ spp. The positive result was identified by visualization in gel electrophoresis at 816-bp. Interview, environmentalÂ investigation, and analysis of incidence rate were performed for epidemiological study. The majority of patients were malesÂ aged 33-48 years old. The main symptoms were fever (100%), abdominal cramps (100%), and bloody diarrhea (11/18;61%).Â Nine of them (9/11; 82%) were confirmed by Gram staining as Gram- negative bacteria, with comma, s-shaped, or seagullÂ appearance, as presumptive Campylobacter spp. Two patients (2/18;11%) were confirmed infected with Campylobacterspp. by PCR and sequencing tests. It has been found that this outbreak was caused by food contaminated withÂ Campylobacter spp. The incidence rate of Campylobacteriosis in this outbreak was 11%.

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Iron Deprivation by Oral Deferoxamine Application Alleviates Acute Campylobacteriosis in a Clinical Murine Campylobacter jejuni Infection Model

et al. 2022

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The progressively rising food-borne Campylobacter jejuni infections pose serious health problems and socioeconomic burdens. Given that antibiotic therapy is not recommended for most campylobacteriosis patients, novel treatment options include strategies targeting iron homeostasis that impacts both C. jejuni virulence and inflammatory cell damage caused by toxic oxygen species. In our preclinical intervention study, we tested potential disease-alleviating effects upon prophylactic oral application of the iron-chelating compound desferoxamine (DESF) in acute murine campylobacteriosis. Therefore, microbiota-depleted IL-10-/- mice received synthetic DESF via the drinking water starting seven days before oral infection with C. jejuni strain 81-176. Results revealed that the DESF application did not reduce gastrointestinal pathogen loads but significantly improved the clinical outcome of infected mice at day 6 post-infection. This was accompanied by less pronounced colonic epithelial cell apoptosis, attenuated accumulation of neutrophils in the infected large intestines and abolished intestinal IFN-γ and even systemic MCP-1 secretion. In conclusion, our study highlights the applied murine campylobacteriosis model as suitable for investigating the role of iron in C. jejuni infection in vivo as demonstrated by the disease-alleviating effects of specific iron binding by oral DESF application in acute C. jejuni induced enterocolitis.

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Correction: Characteristics of hospitalized patients during a large waterborne outbreak of Campylobacter jejuni in Norway

Cited by 6 publications

References 1 publication

Therapeutic Oral Application of Carvacrol Alleviates Acute Campylobacteriosis in Mice Harboring a Human Gut Microbiota

Therapeutic Oral Application of Carvacrol Alleviates Acute Campylobacteriosis in Mice Harboring a Human Gut Microbiota

Campylobacteriosis in An Outbreak of Foodborne Disease at Bantar Gadung Village Palabuhan Ratu

Iron Deprivation by Oral Deferoxamine Application Alleviates Acute Campylobacteriosis in a Clinical Murine Campylobacter jejuni Infection Model

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