Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians

Cheng, Ching‐Yu; Yamashiro, Kenji; Chen, Li Jia; Ahn, Jeeyun; Huang, Lulin; Huang, Lvzhen; Cheung, Chui Ming Gemmy; Miyake, Masahiro; Cackett, Peter; Yeo, Ian; Laude, Augustinus; Mathur, Ranjana; Pang, Junxiong; Sim, Kar Seng; Koh, Adrian; Chen, Peng; Lee, Shu Yen; Wong, Doric; Chan, Choi Mun; Loh, Boon Kwang; Sun, Yaoyao; Dávila, Sonia; Nakata, Isao; Nakanishi, Hideo; Akagi-Kurashige, Yumiko; Gotoh, Noriko; Tsujikawa, Akitaka; Matsuda, Fumihiko; Mori, Keisuke; Yoneya, Shin; Sakurada, Yoichi; Iijima, Hiroyuki; Iida, Tomohiro; Honda, Shigeru; Lai, Timothy Y. Y.; Tam, Pancy Oi Sin; Chen, Haoyu; Tang, Shibo; Ding, Xiaoyan; Wen, Feng; Lu, Fang; Zhang, Xiongze; Shi, Yi; Zhao, Peiquan; Zhao, Bowen; Sang, Jinghong; Gong, Bo; Dorajoo, Rajkumar; Yuan, Jian Min; Koh, Woon Puay; Dam, Rob M. van; Friedlander, Yechiel; Lin, Yin Liang; Hibberd, Martin L.; Foo, Jia Nee; Wang, Ke; Wong, Christina; Tan, Gavin Sw; Park, Sang Jun; Bhargava, Mayuri; Gopal, Lingam; Naing, Thet; Liao, Jiemin; Ong, Peng Guan; Mitchell, Paul; Zhou, Peng; Xie, Xuefeng; Liang, Jinlong; Mei, Junpu; Jin, Xin; Saw, Seang Mei; Ozaki, Mineo; Mizoguchi, Takinori; Kurimoto, Yasuo; Woo, Se Joon; Chung, Hum; Yu, Hyeong Gon; Shin, Joo Young; Park, Dong Ho; Kim, In Taek; Chang, Woo Hyok; Sagong, Min; Lee, Sang Joon; Kim, Hyun Woong; Lee, Ji Eun; Li, Yang; Li, Jianjun; Teo, Yik Ying; Heng, Chew Kiat; Lim, Tock Han; Yang, Suk Kyun; Song, Kyuyoung; Vithana, Eranga N.; Aung, Tin; Bei, Jin Xin; Zeng, Yi Xin; Tai, E. Shyong; Li, Xiao Xin; Yang, Zhenglin; Park, Kyu-Hyung; Pang, Chi Pui; Yoshimura, Nagahisa; Wong, Tien Yin; Khor, Chiea‐Chuen

doi:10.1038/ncomms7817

Cited by 5 publications

(2 citation statements)

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“…Second, rs10490924 and rs 10737680 have been demonstrated to be associated with eye diseases in both European and Asian populations. [ 39 , 40 , 41 ] In addition, according to the 1000 Genomes Consortium, the frequencies of allele effects of rs2596560 (T) and rs9275207 (G) are reported to be similar in European and Asian populations. [ 42 ] These results suggest that our MR analyses are capable of being replicated in Asian populations.…”

Section: Discussionmentioning

confidence: 99%

Short-term duration of diabetic retinopathy as a predictor for development of diabetic kidney disease

Duan,

Liu,

Zhao

et al. 2023

Journal of Translational Internal Medicine

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Background Diabetic retinopathy (DR) is a risk factor for diabetic kidney disease (DKD). Whether the duration, especially the short-term duration, of DR is associated with the development and progression of DKD remains unclear. Materials and Methods A retrospective study and two-sample Mendelian randomization (MR) analysis were conducted. Kidney disease was defined by the urinary albumin-to-creatinine ratio (ACR) and the estimated glomerular filtration rate (eGFR). DR was diagnosed by an expert ophthalmologist by using a digital fundus camera. Binary and ordinal logistic regression analyses were performed. A restricted cubic spline was utilized to detect nonlinear associations. Summary statistics for DR- and DKD-associated single-nuclear polymorphisms (SNPs) were extracted from the FinnGen and the UK Biobank consortia. Results A total of 2674 patients with type 2 diabetes mellitus (T2DM) and type 2 diabetic kidney disease (T2DKD) were included. The prevalence and mean duration of DR increased with elevation of ACR and decline in eGFR. Renal function was significantly reduced in patients with DR in the fifth year of life. Binary and ordinal logistic regression showed that each 1-year increase in DR duration was associated with a 19% risk increase in the development of DKD, 16% in the elevation of ACR, and 21% in the decline of renal function. MR estimates indicated that DR was causally associated with DKD development, with an odds ratio of 2.89. Conclusions DR and the duration of DR were independent risk factors for the development and progression of DKD. The short-term duration of DR may be associated with DKD development. DR had a statistically significant effect on DKD.

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Section: Discussionmentioning

confidence: 99%

Short-term duration of diabetic retinopathy as a predictor for development of diabetic kidney disease

Duan,

Liu,

Zhao

et al. 2023

Journal of Translational Internal Medicine

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“…Age-related macular degeneration (AMD) is an age-associated disease of the eyes, which is the most common cause of visual impairment and blindness in the elderly (1). According to a blind register center survey in Britain, ~50% of blind patients are affected by AMD (2).…”

Section: Introductionmentioning

confidence: 99%

Rhizoma Paridis total saponins alleviate H2O2‑induced oxidative stress injury by upregulating the Nrf2 pathway

et al. 2019

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Rhizoma Paridis total saponins (RPTS) is an active substance isolated from the traditional Chinese medicine Rhizoma Paridis, which possesses multiple biological activities. The aim of the present study was to explore the roles and mechanisms of RPTS in oxidative stress injury of ARPE-19 human retinal pigment epithelial cells. Cell viability, reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP) and apoptosis were determined by Cell Counting kit-8 assay and flow cytometry, respectively. Enzyme-linked immunosorbent assay was performed to detect the expression of oxidative stress markers. Western blotting and reverse transcription-quantitative polymerase chain reaction were used to determine the expression levels of related genes and proteins. The results revealed that RPTS enhanced cell viability and reduced H2O2-induced oxidative stress of ARPE-19 human retinal pigment epithelial cells. RPTS increased the MMP of ARPE-19 cells compared with in H2O2-treated ARPE-19 cells. In addition, RPTS suppressed ROS production and apoptosis of H2O2-treated ARPE-19 cells. Additionally, RPTS modulated the expression levels of apoptosis-associated proteins and the nuclear factor 2-related factor 2 (Nrf2) pathway. In conclusion, RPTS alleviated H2O2-induced oxidative stress injury by upregulating the Nrf2 pathway. The potential effects of RPTS on protection against H2O2-induced apoptosis of ARPE-19 cells suggested that RPTS may be a potential therapeutic target for preventing age-related macular degeneration.

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Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations

Kumar¹,

Pouw²,

Autio³

et al. 2022

The American Journal of Human Genetics

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Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians

Cited by 5 publications

References 0 publications

Short-term duration of diabetic retinopathy as a predictor for development of diabetic kidney disease

Short-term duration of diabetic retinopathy as a predictor for development of diabetic kidney disease

Rhizoma Paridis total saponins alleviate H2O2‑induced oxidative stress injury by upregulating the Nrf2 pathway

Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations

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