2013
DOI: 10.1038/ejhg.2013.144
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Correction for multiple testing in a gene region

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Cited by 41 publications
(31 citation statements)
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“…Then, ZMVN(0,normalΣ), where Σ=bold-italic0.33emDD. We consider estimates of the effective number of tests via the Galwey () method and the modification of the Gao approach described by Hendricks, Dupuis, Logue, Myers, and Lunetta () Let normalΛ be the vector of eigenvalues corresponding to the eigendecomposition of normalΣ. A Galwey estimate for the effective number of gene set level tests, R Galwey eff , is given by R Galwey eff =false(λrfalse)2λr for λr>0, where λr indicates the r th largest eigenvalue.…”
Section: Methodsmentioning
confidence: 99%
“…Then, ZMVN(0,normalΣ), where Σ=bold-italic0.33emDD. We consider estimates of the effective number of tests via the Galwey () method and the modification of the Gao approach described by Hendricks, Dupuis, Logue, Myers, and Lunetta () Let normalΛ be the vector of eigenvalues corresponding to the eigendecomposition of normalΣ. A Galwey estimate for the effective number of gene set level tests, R Galwey eff , is given by R Galwey eff =false(λrfalse)2λr for λr>0, where λr indicates the r th largest eigenvalue.…”
Section: Methodsmentioning
confidence: 99%
“…The effective number of independent tests was 54,403 for the 282 locus-by-trait pairs (Table S27). Considering that our effective number estimates were already conservative 39 , we used 5E-7 (<0.05/54,403) as the significance threshold. Subsequently, we found 434 association signals (Table S5).…”
Section: Fine-mapping Of Dairy Cattle Traitsmentioning
confidence: 99%
“…Second, we confirmed the independence of 20 SNPs that were located within ±2 MB of a known susceptibility region by conditioning the identified signals on the nearby known signal. Since these 20 SNPs are already genome-wide significant in the original GWAS scan and the conditional analyses restricted to local regions, we therefore used a significance threshold of P<1x10 -6 to control for type-one error 28 .…”
Section: Conditional Analysesmentioning
confidence: 99%