Correction: Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets

Sørensen, Thorkild I A; Boutin, Philippe; Taylor, Moira A.; Larsen, Lesli H.; Verdich, Camilla; Petersen, Liselotte; Holst, Claus; Echwald, Søren M.; Dina, Christian; Toubro, Søren; Petersen, Martin R.; Polàk, Jan; Clément, Karine; Martínez, J. Alfredo; Langin, Dominique; Oppert, Jean‐Michel; Štich, Vladimír; Macdonald, I. A.; Arner, Peter; Pedersen, Oluf; Astrup, Arne; Froguel, Philippe

doi:10.1371/journal.pctr.0010023

Cited by 19 publications

(36 citation statements)

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“…Previously 42 SNPs in 26 candidate genes for obesity (not including FTO) were examined in relation to weight loss in the NUGENOB study (Nutrient-gene interaction in human obesity: implication for dietary guidelines), in which average weight loss was 6.8 kg after 10 weeks. 23 The results suggested that the 42 SNPs under study did not have any major impact on weight reduction during short-term either high-fat (HF) or low-fat (LF) hypo-energetic diet in obese individuals. In this context we decided to investigate the effect of FTO rs9939609 on diet-induced weight loss and associated phenotypes including possible interactions with macronutrient content of the weight loss diet in the NUGENOB-cohort.…”

Section: Introductionmentioning

confidence: 86%

“…NUGENOB was a multi-centre study including eight clinical centres in seven European countries (Sweden, Denmark, UK, The Netherlands, Czech Republic, France (two clinical centres), and Spain) and has been described in detail elsewhere (www.nugenob.org). 23,24 Participants were recruited from May 2001 until September 2002 through the media, from waiting lists or ongoing population studies and by self-referral or referral from a general practitioner or other clinical units and local obesity organizations. Inclusion criteria were: body mass index (BMI; kg m À2 ) X30, and age 20-50 years.…”

Section: Methodsmentioning

confidence: 99%

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Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans

et al. 2009

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Background: The A risk allele of rs9939609 of the fat mass-and obesity-associated gene (FTO) increases body fat mass. Objective: To examine whether FTO rs9939609 affects obese individuals' response to a high-fat, low-carbohydrate (CHO) (HF) or low-fat, high-CHO (LF), hypo-energetic diet and whether the effect of the FTO variant depends on dietary fat and CHO content. Design: In a 10-week, European, multi-centre dietary intervention study 771 obese women and men were randomized to either LF (20-25% of energy (%E) from fat, 60-65%E from CHO) or HF (40-45%E from fat, 40-45%E from CHO), hypo-energetic diet (measured resting metabolic rate multiplied by 1.3-600 kcal day À1 ). Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation as % of REE (FatOx), insulin release (HOMA-b) and a surrogate measure of insulin resistance (HOMA-IR) were measured at baseline and after the intervention. In all, 764 individuals were genotyped for FTO rs9939609. Results: For A-allele carriers the drop-out rate was higher on HF than LF diet (in AT, P ¼ 0.002; in AT/AA combined, P ¼ 0.003). Among those individuals completing the intervention, we found no effect of FTO rs9939609 genotype on Dweight, DFM, DFFM, DWC or DFatOx. However, participants with TT had a smaller reduction in REE on LF than on HF diet (75 kcal/24 h; interaction: P ¼ 0.0055). These individuals also showed the greatest reduction in HOMA-b and HOMA-IR (interaction: P ¼ 0.0083 and P ¼ 0.047). Conclusion:The FTO rs9939609 may interact with the macronutrient composition in weight loss diets in various ways; carriers of the A allele on LF diet appear to have a lower risk for drop out, and TT individuals have a smaller decrease in REE and greater decrease in HOMA-b and HOMA-IR on LF than on HF diet.

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Section: Introductionmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans

et al. 2009

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“…High-protein diets may also be related to higher levels of thermogenesis, which can increase energy efficiency during weight loss and help avoiding weight regain (46) . It was shown by one study that body-weight loss and low weight-gain depend on the high-protein content of the diet, rather than the lowcarbohydrate component, while it is unrelated to the concomitant fat-content of the diet (47) . Furthermore, the Mediterranean and Dietary Approaches to Stop Hypertension diet, which was recommended by Champagne et al (48) and Svetkey et al (43) for the weight reduction phase, encourages intakes of fruit, vegetables, nuts, and whole grains and discourages intakes of red and processed meats and saturated fat.…”

Section: Effectiveness Of Energy Restriction and Macronutrient Composmentioning

confidence: 99%

Long-term weight status in regainers after weight loss by lifestyle intervention: status and challenges

et al. 2014

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After having participated in a weight loss trial, most participants do not stabilise the obtained weight loss but return to their initial weight. The aim of this review is to describe the main determinants of continued low weight status after weight loss, and the effectiveness of physical activity (PA), energy restriction and macronutrient composition of the diet for low long-term weight regain. Studies with intervention periods of at least 3 months duration of weight reduction measures and a follow-up at least 2 years after the intervention period were considered as eligible for the review. Owing to limited data, the studies describing the role of PA in weight management were eligible with a follow-up of 1 year only. It appears that a diet with self-regulation of dietary intake seems to be given a prominent role in the strategy of successful long-term weight loss among the obese. This measure could be combined with behaviour therapy and PA and tailored to the individual situation. However, considering available evidence it is difficult to conclude regarding unambiguous measures and to recommend a specific dietary intervention. Nevertheless, interventions should be effective in promoting intrinsic motivation and self-efficacy. The harmonisation and standardisation of data collection in the follow-up period of long-term weight loss studies is a major challenge.

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“…In an extensive genetic study of weight reduction including 648 obese subjects who underwent intervention with hypoenergetic diet, ENPP1 was nominally associated with weight loss. 149 Endocrine and paracrine action of adipocytes Human adipose tissue secrete hormones, cytokines and other molecules, together termed 'adipokines', which besides having local effects through release into the circulation participate in the regulation of whole body metabolism. The best characterized obesity gene, leptin, encodes a peptide hormone secreted exclusively by adipocytes.…”

Section: Pathways Controlling Lipid Storage In Adipocytesmentioning

confidence: 99%

Obesity and polymorphisms in genes regulating human adipose tissue

Dahlman

Arner

2007

Int J Obes

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Obesity is the result of an imbalance between food intake and energy expenditure resulting in the storing of energy as fat. Adipose tissue contains the largest store of energy in the body and plays important roles in regulating energy partitioning. Developments in genomics, in particular microarray-based expression profiling, have provided scientists with a number of new candidate genes whose expression in adipose tissue is regulated by obesity. Integrating expression profiles with genome-wide linkage and/or association analyses is a promising strategy to identify new genes underlying susceptibility to obesity. This article provides a comprehensive review of adipose-tissue-expressed genes implicated in predisposition to human obesity. The authors consider the following genes of particular interest: peroxisome proliferator-activated receptor gamma and, potentially, INSIG2 acting in adipogenesis; the adrenoreceptors beta 2 and 3, as well as hormone-sensitive lipase acting on lipolysis; uncoupling protein 2 acting in mitochondria energy expenditure; and among secreted molecules the cytokine tumor necrosis factor alpha and the hormone leptin. With the rapid development in genome research, we predict that additional alleles in genes regulating adipose tissue function will be established as risk factors for common obesity in the coming years. This has important implications for the prevention of obesity and may also offer new therapeutic targets.

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Correction: Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets

Cited by 19 publications

References 0 publications

Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans

Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans

Long-term weight status in regainers after weight loss by lifestyle intervention: status and challenges

Obesity and polymorphisms in genes regulating human adipose tissue

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