Obesity and polymorphisms in genes regulating human adipose tissue

Dahlman, Ingrid; Arner, Peter

doi:10.1038/sj.ijo.0803657

Cited by 55 publications

(35 citation statements)

References 193 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PPAR-γ has previously been reported as associated with BMI (Masud et al 2003) and not associated with BMI (Dahlman and Arner 2007). In our study, Ala carriers have lower BMI, which is associated with a reduced risk of type 2 diabetes mellitus in the general population.…”

Section: Discussionsupporting

confidence: 56%

Pro12Ala polymorphism in PPAR-γ2 and dementia in Chinese nonagenarians/centenarians

Yue

Dong

Huang

et al. 2010

AGE

View full text Add to dashboard Cite

We examined the existence of a relationship between polymorphism and dementia in subjects aged 90 years and above. The sample included 732 unrelated Chinese nonagenarians/centenarians (aged 90-108 years, mean age 93.68 years; 67.5% women). The Pro12Ala variant was examined using polymerase chain reaction restriction fragment length polymorphism. Cognitive function was measured with 30-item minimental state examination. The genotype frequencies of the Pro12Ala polymorphism were 0% Ala12Ala, 9.1% Pro12Ala, and 90.9% Pro12Pro. The prevalence rates of dementia were 64.9% in the whole sample (45.0% for men and 74.5% for women). In both men and women, between subjects with and without 12Ala carriers, there was no significant difference in cognitive function scores and also no significant difference in prevalence of dementia; there was no significant difference in frequency of 12Ala carriers between subjects with and without dementia. Multiple logistic regression was performed by adjusting clinical factors that are thought to be associated with cognitive function or with 12Ala carriers. We found that 12Ala is not a risk factor for dementia. We found that Pro12Ala polymorphism in PPAR-γ2 was not directly correlated with dementia among Chinese nonagenarians and centenarians.

show abstract

Section: Discussionsupporting

confidence: 56%

Pro12Ala polymorphism in PPAR-γ2 and dementia in Chinese nonagenarians/centenarians

Yue

Dong

Huang

et al. 2010

AGE

View full text Add to dashboard Cite

show abstract

“…These abnormalities in catecholamine function promote the release of NEFA from the visceral adipocytes through the portal system and might cause several of the metabolic complications of upper-body obesity. In addition, several polymorphisms in genes encoding b 1 -(ADRB1), b 2 -(ADRB2) and b 3 -(ADRB3) adrenergic receptors have been associated with altered cathecolamineinduced adipocyte lipolysis and with obesity (403,404) . The polymorphisms in the ADRB2 gene are highly frequent in obesity and associated with altered b 2 -adrenergic function (Arg16Gly and Gln27Glu) and catecholamine-induced lipolysis in subcutaneous fat cells (Arg16Gly and Thr164Ile) (42,405,406) .…”

Section: Lipolysis In Human Obesitymentioning

confidence: 99%

Regulation of adipocyte lipolysis

et al. 2014

View full text Add to dashboard Cite

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting conditions or times of elevated energy demands is tightly regulated by neuroendocrine signals, resulting in the activation of lipolytic enzymes. Among the classic regulators of lipolysis, adrenergic stimulation and the insulin-mediated control of lipid mobilisation are the best known. Initially, hormone-sensitive lipase (HSL) was thought to be the rate-limiting enzyme of the first lipolytic step, while we now know that adipocyte TAG lipase is the key enzyme for lipolysis initiation. Pivotal, previously unsuspected components have also been identified at the protective interface of the lipid droplet surface and in the signalling pathways that control lipolysis. Perilipin, comparative gene identification-58 (CGI-58) and other proteins of the lipid droplet surface are currently known to be key regulators of the lipolytic machinery, protecting or exposing the TAG core of the droplet to lipases. The neuroendocrine control of lipolysis is prototypically exerted by catecholaminergic stimulation and insulin-induced suppression, both of which affect cyclic AMP levels and hence the protein kinase A-mediated phosphorylation of HSL and perilipin. Interestingly, in recent decades adipose tissue has been shown to secrete a large number of adipokines, which exert direct effects on lipolysis, while adipocytes reportedly express a wide range of receptors for signals involved in lipid mobilisation. Recently recognised mediators of lipolysis include some adipokines, structural membrane proteins, atrial natriuretic peptides, AMP-activated protein kinase and mitogen-activated protein kinase. Lipolysis needs to be reanalysed from the broader perspective of its specific physiological or pathological context since basal or stimulated lipolytic rates occur under diverse conditions and by different mechanisms.

show abstract

“…Although the maintenance of body weight is under genetic control, mutations in a single gene rarely result in severe obesity (4). Previous studies reported associations between BMI or obesity and genetic variants, suggesting that polymorphisms in the genes linked to various pathways may contribute to the development of obesity (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Association of annexin A5 polymorphisms with obesity

et al. 2013

View full text Add to dashboard Cite

Abstract. Annexin A5 (ANXA5), which is known as a protein with anticoagulative function, may play a role in triglyceride biosynthesis. Triglycerides are involved in lipid and energy metabolism, which are important in the elucidation of obesity. To investigate the association between single-nucleotide polymorphisms (SNPs) of ANXA5 and obesity in a Korean population, 372 participants (213 overweight/obese individuals and 159 control subjects) were enrolled from the Kyung Hee University Medical Center and Keimyung University Dongsan Medical Center. The genotypes of five SNPs (rs12510548, rs4240260, rs3756281, rs13136094 and rs6534313) were evaluated in ANXA5 using the multiple logistic regression analysis with the codominant 1, codominant 2, dominant, recessive and log-additive models. The genotype and allele frequencies of the five investigated SNPs exhibited significant differences between the control and the overweight/obese groups: rs12510548 (P=0.004 in the codominant 2 model, P=0.0019 in the recessive model, P=0.027 in the log-additive model and P=0.026 in allele frequencies); rs4240260 (P=0.002 and Fisher's exact P=0.0006 in the codominant 2 model, P=0.0007 and Fisher's exact P=0.0007 in the recessive model, P=0.020 and Fisher's exact P=0.0019 in the log-additive model and P=0.020 in allele frequencies); rs3756281 (P=0.016 in the codominant 2 model and P=0.0094 in the recessive model); rs13136094 (P=0.0030 and Fisher's exact P=0.0011 in the codominant 2 model, P=0.0012 and Fisher's exact P=0.0013 in the recessive model, P=0.034 and Fisher's exact P=0.0035 in the log-additive model and P=0.024 in allele frequencies); and rs6534313 (P=0.0010 and Fisher's exact P=0.0003 in the codominant 2 model, P=0.0003 and Fisher's exact P=0.0003 in the recessive model, P=0.0075 and Fisher's exact P=0.0010 in the log-additive model and P=0.005 in allele frequencies). Two haplotypes were weakly associated with obesity (GGATG, P=0.037 and CAGCC, P=0.020). Results of the present study suggested that ANXA5 may be associated with the development of obesity in a Korean population.

show abstract

Obesity and polymorphisms in genes regulating human adipose tissue

Cited by 55 publications

References 193 publications

Pro12Ala polymorphism in PPAR-γ2 and dementia in Chinese nonagenarians/centenarians

Pro12Ala polymorphism in PPAR-γ2 and dementia in Chinese nonagenarians/centenarians

Regulation of adipocyte lipolysis

Association of annexin A5 polymorphisms with obesity

Contact Info

Product

Resources

About