Correction: Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis

Qiu, Xie; Liu, Wei; Zheng, Yifan; Zeng, Kai; Wang, Hao; Sun, Han‐Dong; Dai, Jianhua

doi:10.1186/s12890-022-02170-0

BMC Pulm Med

2022

DOI: 10.1186/s12890-022-02170-0

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Correction: Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis

Xie Qiu

Wei Liu

Yifan Zheng

et al.

Abstract: The original article has been updated accordingly. The authors apologize for any inconvenience caused and thank you for reading this correction.

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Nucleophosmin promotes lung adenocarcinoma cell proliferation, migration and invasion by activating the EGFR/MAPK signaling pathway

Zhu

et al. 2023

Oncol Rep

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Lung adenocarcinoma (LUAD) is the main cause of death globally. The present study investigated the prognostic value and functional verification of nucleophosmin (NPM1) in LUAD. LUAD and normal samples from The Cancer Genome Atlas were analyzed to identify whether NPM1 is associated with LUAD prognosis. NPM1 protein expression level was verified by western blotting. Cell proliferation, migration and invasion were detected by Cell Counting Kit-8, wound healing and Transwell assays, respectively. EGFR/MAPK pathway-related proteins [phosphorylated (p)-EGFR/EGFR, p-MEK/MEK, and p-ERK/ERK] expression was measured through western blotting. A xenograft tumor mice model was constructed to perform the in vivo verification. NPM1 was upregulated in LUAD cells, and high-level NPM1 indicated poor prognosis in patients with LUAD. In vitro experiments revealed that NPM1 knockdown inhibited LUAD cell proliferation, migration and invasion. Moreover, protein expression of p-EGFR/EGFR, p-MEK/MEK and p-ERK/ERK was reduced with the NPM1 silencing. Furthermore, EGF, an activator of the EGFR/MAPK pathway, reversed the effects of NPM1. In vivo experiments showed that NPM1 knockdown inhibited tumor growth and protein levels of p-EGFR/EGFR, p-MEK/MEK and p-ERK/ERK. NPM1 is related to the poor prognosis of LUAD and promotes the malignant progression of LUAD by activating the EGFR/MAPK pathway. This discovery provides a new potential therapeutic target for the diagnosis and treatment of LUAD.

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Nucleophosmin promotes lung adenocarcinoma cell proliferation, migration and invasion by activating the EGFR/MAPK signaling pathway

Zhu

et al. 2023

Oncol Rep

View full text Add to dashboard Cite

show abstract

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Correction: Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis

Abstract: The original article has been updated accordingly. The authors apologize for any inconvenience caused and thank you for reading this correction.

Cited by 1 publication

References 0 publications

Nucleophosmin promotes lung adenocarcinoma cell proliferation, migration and invasion by activating the EGFR/MAPK signaling pathway

Nucleophosmin promotes lung adenocarcinoma cell proliferation, migration and invasion by activating the EGFR/MAPK signaling pathway

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