Correction: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2

Nader, Nancy; Dib, Maya; Hodeify, Rawad; Courjaret, Raphael Jean; Elmi, Asha; Hammad, Ayat S.; Dey, Raja; Huang, Xin; Machaca, Khaled

doi:10.1371/journal.pbio.3001117

Cited by 7 publications

(6 citation statements)

References 1 publication

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“…More recent structural analyses suggest the N-terminal of mPRs is intracellular [ 20 , 27 ], which is supported by the recent prediction of the “positive-inside rule” in which higher proportions of positively charged amino acids are intracellular [ 21 ]. This orientation is supported by results using Xenopus mPRβ clones with N- terminal fluorescent tags under permeabilized and nonpermeabilized conditions [ 25 ]. The C-terminal domain of mPRs is longer than that of the AdipoRs and is predicted to form an eighth TM domain with an intracellular C-terminal [ 20 , 27 ].…”

Section: Cellular Distribution and Membrane Topologymentioning

confidence: 71%

“…Localization of mPRs in this region is not unexpected since membrane receptors are trafficked to the cell membrane from the endoplasmic reticulum, which usually retains most of the receptor protein [ 23 ]. After ligand binding, mPRs are rapidly internalized by a clathrin-dependent mechanism [ 24 , 25 ], resulting in decreased cell-surface expression of the receptor, which is slowly restored [ 24 ]. The restoration of mPRs on the cell surface involves the participation of various adaptor proteins.…”

Section: Cellular Distribution and Membrane Topologymentioning

confidence: 99%

“…Activation of PI3K/Akt signaling through mPRs is usually accompanied by induction of MAPkinase signaling and ERK1/2 phosphorylation [ 8 , 9 , 25 , 37 , 47 , 48 , 50 , 51 , 60 , 63 ]. Both PI3K/Akt and MAPkinase signaling pathways mediate the functions of mPRα in various cell models, including progestogen stimulation of sperm motility and oocyte maturation in fish [ 8 , 9 ], anti-apoptosis in fish ovarian follicle and human breast cancer cells [ 37 , 51 , 60 ], nitric oxide production in human umbilical vascular endothelial cells [ 48 ], and the progesterone-induced increase in sarcoplasmic reticulum calcium levels and decrease in myosin light chain (MLC) phosphorylation in human vascular smooth muscle cells resulting in their relaxation [ 50 , 63 ].…”

Section: Second Messenger Signaling Through G Proteinsmentioning

confidence: 99%

“…Information on potential interactions between PGRMC1 and other mPR subtypes in vertebrate cells is currently lacking. mPRβ mediates progesterone-induced meiotic maturation of Xenopus oocytes [ 10 , 25 ] and also participates in progestin-induced maturation of zebrafish oocytes [ 80 ]. Nader and colleagues have provided evidence that APPL1 interacts with mPRβ in Xenopus oocytes and that this interaction is essential for progesterone induction of oocyte maturation [ 25 ].…”

Section: Association Of Mprs With Adaptor Proteinsmentioning

confidence: 99%

“…mPRβ mediates progesterone-induced meiotic maturation of Xenopus oocytes [ 10 , 25 ] and also participates in progestin-induced maturation of zebrafish oocytes [ 80 ]. Nader and colleagues have provided evidence that APPL1 interacts with mPRβ in Xenopus oocytes and that this interaction is essential for progesterone induction of oocyte maturation [ 25 ]. These authors suggested that APPL1 is likely involved in progesterone-induced endocytosis of mPRβ [ 25 ].…”

Section: Association Of Mprs With Adaptor Proteinsmentioning

confidence: 99%

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Membrane Progesterone Receptors (mPRs, PAQRs): Review of Structural and Signaling Characteristics

Thomas

2022

Cells

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The role of membrane progesterone receptors (mPRs), which belong to the progestin and adipoQ receptor (PAQR) family, in mediating rapid, nongenomic (non-classical) progestogen actions has been extensively studied since their identification 20 years ago. Although the mPRs have been implicated in progestogen regulation of numerous reproductive and non-reproductive functions in vertebrates, several critical aspects of their structure and signaling functions have been unresolved until recently and remain the subject of considerable debate. This paper briefly reviews recent developments in our understanding of the structure and functional characteristics of mPRs. The proposed membrane topology of mPRα, the structure of its ligand-binding site, and the binding affinities of steroids were predicted from homology modeling based on the structures of other PAQRs, adiponectin receptors, and confirmed by mutational analysis and ligand-binding assays. Extensive data demonstrating that mPR-dependent progestogen regulation of intracellular signaling through mPRs is mediated by activation of G proteins are reviewed. Close association of mPRα with progesterone membrane receptor component 1 (PGRMC1), its role as an adaptor protein to mediate cell-surface expression of mPRα and mPRα-dependent progestogen signaling has been demonstrated in several vertebrate models. In addition, evidence is presented that mPRs can regulate the activity of other hormone receptors.

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Section: Cellular Distribution and Membrane Topologymentioning

confidence: 71%

Section: Cellular Distribution and Membrane Topologymentioning

confidence: 99%

Section: Second Messenger Signaling Through G Proteinsmentioning

confidence: 99%

Section: Association Of Mprs With Adaptor Proteinsmentioning

confidence: 99%

Section: Association Of Mprs With Adaptor Proteinsmentioning

confidence: 99%

See 3 more Smart Citations

Membrane Progesterone Receptors (mPRs, PAQRs): Review of Structural and Signaling Characteristics

Thomas

2022

Cells

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Regulation of oocyte maturation: Role of conserved ERK signaling

Das

Arur

2022

Molecular Reproduction Devel

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During oogenesis, oocytes arrest at meiotic prophase I to acquire competencies for resuming meiosis, fertilization, and early embryonic development. Following this arrested period, oocytes resume meiosis in response to species‐specific hormones, a process known as oocyte maturation, that precedes ovulation and fertilization. Involvement of endocrine and autocrine/paracrine factors and signaling events during maintenance of prophase I arrest, and resumption of meiosis is an area of active research. Studies in vertebrate and invertebrate model organisms have delineated the molecular determinants and signaling pathways that regulate oocyte maturation. Cell cycle regulators, such as cyclin‐dependent kinase (CDK1), polo‐like kinase (PLK1), Wee1/Myt1 kinase, and the phosphatase CDC25 play conserved roles during meiotic resumption. Extracellular signal‐regulated kinase (ERK), on the other hand, while activated during oocyte maturation in all species, regulates both species‐specific, as well as conserved events among different organisms. In this review, we synthesize the general signaling mechanisms and focus on conserved and distinct functions of ERK signaling pathway during oocyte maturation in mammals, non‐mammalian vertebrates, and invertebrates such as Drosophila and Caenorhabditis elegans.

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Adiponectin-mediated promotion of CD44 suppresses diabetic vascular inflammatory effects

Duan¹,

Zhang²,

Xing³

et al. 2023

iScience

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Correction: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2

Cited by 7 publications

References 1 publication

Membrane Progesterone Receptors (mPRs, PAQRs): Review of Structural and Signaling Characteristics

Membrane Progesterone Receptors (mPRs, PAQRs): Review of Structural and Signaling Characteristics

Regulation of oocyte maturation: Role of conserved ERK signaling

Adiponectin-mediated promotion of CD44 suppresses diabetic vascular inflammatory effects

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