Correction of acute stress-induced disorders of hemostasis using the KVCh-NO apparatus

Abstract

The problem of stress induced disorders of hemosta sis (ischemia, acute myocardial infarction, disseminated intravascular coagulation (DIC), thromboembolia, etc.) is important for clinics and basic research in medicine. These diseases cause disability and premature death of creative adults [17].Discoordination of systems of hemorheology, immu nity, hemostasis, and homeokinesis is a pathogenic mech anism of acute stress reaction [21]. Normal functions of visceral systems and the organism as a whole depend on invariability of intraorganismal media.Stress induced disorders are due to sharp changes in environmental conditions associated with industrial fac tors, urbanization, ecological disasters, and so called dis adaptation diseases.Pharmacological correction of stress induced disor ders causes not only positive effect but also allergic reac tion [21].Terahertz electromagnetic therapy (THG therapy) is a promising new method for treatment of various diseases [3]. In cardiology microwave therapy has been successful ly used for 20 years. THG therapy is used in surgery, trau matology, gynecology, dermatology, endocrinology, etc.The frequency range of THG therapy falls between 100 GHz and 10 THz or from 3 mm to 30 µm. From the bottom and top this range is limited by electronic transi tions in semiconductor structures (100 GHz) and maxi mum wavelength of transitions in laser structures, respec tively. This range falls between the EHF (100 300 GHz) and infrared wavelength ranges [4].It has been found that living organisms use radiation in this range for communication and control. Some living organisms are able to emit microwave radiation. The THG induced signals in living organisms simulate inter nal communication and control signals (information sig nals) in biological objects. This restores the radiation inherent in a healthy organism [12]. On the other hand, the THG frequency range includes emission and absorp tion spectra of most important cell metabolites (NO, O 2 , CO 2 , CO, OH , etc.) [14]. The biophysical effects of THG radiation can be used in biomedical engineering: THG therapy and THG diagnosis [3].Molecular emission and absorption spectra (MEAS) of nitric oxide (150, 176 150, 664 GHz) are of consider able interest in experimental research because NO is an important mediator of many physiological and patho physiological processes. NO is a unique second messen ger in most living cells. For example, NO mediates vasodilatation, bronchodilation, neurotransmission, platelet aggregation, immune reactions, muscular ten sion, memory, renal hemodynamics, glomerulofiltration, and some pathological processes [7,16,20]. It was shown that the MEAS of NO had a stress limiting effect [11].Noninvasive methods of NO secretion regulation are of considerable interest for basic research and medical practice. Low intensity THG radiation in MEAS of NO (150, 176 150, 664 GHz) provides a promising approach to this problem.There is experimental evidence that this radiation affects microcirculatory and rheological properties of blood a...

Behavioral effect of terahertz waves in male mice

“…This assumption is confirmed by the absence of significant changes in the total time spent in the area of radia- tion. The exposure to a distant source of THz waves probably has little effect and directly modulates the tissues, cells, and biological molecules, which is consistent with published data [4,8,9]. Irradiation for 30 min had a strong effect on the state of experimental animals.…”

The usage of THz radiation of nitrogen oxide occurrence in blood antioxidant characteristics correction and lipid peroxidation process under stress conditions

“…There was demonstrated that THz-band of nitrogen oxide occurrence that had been performed alongside with a stress agent action, prevents stress-dependent changes progressing in an antioxidant system of an organism and decreases LPO activity. This may be connected with an increase of reactivity of free endogenic nitrogen oxide or an increase of its concentration because of the influence of the THz-band of MASO of 150.176-150.664 GHz nitrogen oxide occurrence directly on NOS and their catalyzation [1,[6][7][8][9]. It should be noticed that the THz-band irradiation of nitrogen oxide occurrence had evident stress-limiting effect [5,10], because of the overconcentration of corticosterone and catecholamines as well [10].…”

“…Irradiator had been located 1.5 cm above the body of an animal. The generator radiant power was 0.7 mW, the power density that arrives at the 3 cm² skin area was 0.2 mW/cm² [9].…”

Sex-specific differences in changes of disturbed functional activity of platelets in albino rats under the effect of terahertz electromagnetic radiation at nitric oxide frequencies

“…Immobilization stress (a single 3-h fixation of animals in the supine posture) [5] served as the model of disorders in the intravascular component of microcirculation. The animals were exposed to TFB waves at NO frequency for 15 or 30 min using a KVCh-NO generator [10].…”