The problem of stress induced disorders of hemosta sis (ischemia, acute myocardial infarction, disseminated intravascular coagulation (DIC), thromboembolia, etc.) is important for clinics and basic research in medicine. These diseases cause disability and premature death of creative adults [17].Discoordination of systems of hemorheology, immu nity, hemostasis, and homeokinesis is a pathogenic mech anism of acute stress reaction [21]. Normal functions of visceral systems and the organism as a whole depend on invariability of intraorganismal media.Stress induced disorders are due to sharp changes in environmental conditions associated with industrial fac tors, urbanization, ecological disasters, and so called dis adaptation diseases.Pharmacological correction of stress induced disor ders causes not only positive effect but also allergic reac tion [21].Terahertz electromagnetic therapy (THG therapy) is a promising new method for treatment of various diseases [3]. In cardiology microwave therapy has been successful ly used for 20 years. THG therapy is used in surgery, trau matology, gynecology, dermatology, endocrinology, etc.The frequency range of THG therapy falls between 100 GHz and 10 THz or from 3 mm to 30 µm. From the bottom and top this range is limited by electronic transi tions in semiconductor structures (100 GHz) and maxi mum wavelength of transitions in laser structures, respec tively. This range falls between the EHF (100 300 GHz) and infrared wavelength ranges [4].It has been found that living organisms use radiation in this range for communication and control. Some living organisms are able to emit microwave radiation. The THG induced signals in living organisms simulate inter nal communication and control signals (information sig nals) in biological objects. This restores the radiation inherent in a healthy organism [12]. On the other hand, the THG frequency range includes emission and absorp tion spectra of most important cell metabolites (NO, O 2 , CO 2 , CO, OH , etc.) [14]. The biophysical effects of THG radiation can be used in biomedical engineering: THG therapy and THG diagnosis [3].Molecular emission and absorption spectra (MEAS) of nitric oxide (150, 176 150, 664 GHz) are of consider able interest in experimental research because NO is an important mediator of many physiological and patho physiological processes. NO is a unique second messen ger in most living cells. For example, NO mediates vasodilatation, bronchodilation, neurotransmission, platelet aggregation, immune reactions, muscular ten sion, memory, renal hemodynamics, glomerulofiltration, and some pathological processes [7,16,20]. It was shown that the MEAS of NO had a stress limiting effect [11].Noninvasive methods of NO secretion regulation are of considerable interest for basic research and medical practice. Low intensity THG radiation in MEAS of NO (150, 176 150, 664 GHz) provides a promising approach to this problem.There is experimental evidence that this radiation affects microcirculatory and rheological properties of blood a...

This article describes the manufacturing technology of biocompatible flexible strain-sensitive sensor based on Ecoflex silicone and multi-walled carbon nanotubes (MWCNT). The sensor demonstrates resistive behavior. Structural, electrical, and mechanical characteristics are compared. It is shown that laser radiation significantly reduces the resistance of the material. Through laser radiation, electrically conductive networks of MWCNT are formed in a silicone matrix. The developed sensor demonstrates highly sensitive characteristics: gauge factor at 100% elongation −4.9, gauge factor at 90° bending −0.9%/deg, stretchability up to 725%, tensile strength 0.7 MPa, modulus of elasticity at 100% 46 kPa, and the temperature coefficient of resistance in the range of 30–40 °С is −2 × 10−3. There is a linear sensor response (with 1 ms response time) with a low hysteresis of ≤3%. An electronic unit for reading and processing sensor signals based on the ATXMEGA8E5-AU microcontroller has been developed. The unit was set to operate the sensor in the range of electrical resistance 5–150 kOhm. The Bluetooth module made it possible to transfer the received data to a personal computer. Currently, in the field of wearable technologies and health monitoring, a vital need is the development of flexible sensors attached to the human body to track various indicators. By integrating the sensor with the joints of the human hand, effective movement sensing has been demonstrated.

The effects of terahertz irradiation at the nitric oxide frequencies (150.176-150.664 GHz) on the intensity of lipoperoxidation and antioxidant properties of the blood were examined on albino rats subjected to immobilization stress. This terahertz irradiation completely normalized LPO processes and functional activity of antioxidants in stressed rats.

Stress reaction contributes significantly to many forms of human pathology. Stress reaction is induced by various environmental factors [1]. Changes in hemostasis are decisive pathogenic factors of acute and chronic stress reaction [1,2]. Under conditions of long term and inten sive stress, vascular activation of hemostasis system results in thrombosis and modification of the coagulation cas cade, functional activity of thrombocytes, and dissemi nated intravascular clotting [2].Presently available methods of drug correction of hemostasis system dysfunction are ineffective, require laboratory monitoring, and have various contraindica tions. The literature indicates high cost of drug treatment of hemostasis and fibrinolysis system dysfunction [3].Electromagnetic wave therapy within the frequency range 10 2 10 4 GHz or wavelength range 3 mm 30 μm is a promising method for treatment of various diseases [4,5]. The terahertz frequency range (TFR) is widely used in medicine because it has an effect on cell metabolites (NO, O 2 , СО 2 , СО, ОН , etc.) [6]. Complicated biolog ical systems are based on stable metabolites. Deterministic radiation induced control of cell metabo lism depends on radiation emission and absorption spec tra. Emission and absorption spectra of a given metabolite determine its medical properties. The metabolite and electromagnetic field constitute a unified system [4,5].TFR of 129.0 GHz frequency range (the absorption range of atmospheric oxygen) is of significant medical interest [5]. Deficiency in organs and tissues results in hypoxia and ischemia. Therefore, TFR at the frequency of molecular oxygen is very important [6].The goal of this work was to use terahertz electro magnetic waves for correcting hemostasis functions. MethodsBlood was collected from 75 male mongrel white rats (body weight, 180 200 g).Immobilization stress (fixation of supine rats for 3 h) was used as model of hemocoagulation and fibrinolysis dysfunction [7]. The test was run in pentaplicate in 15The influence of terahertz range waves at 129.0 GHz (frequency of the molecular spectrum of radiation and absorption of atmospheric oxygen) on faulty coagulation hemostasis and its fibrinolysis potential was studied under conditions of experimental stress. Considerable hypercoagulation and the suppression of fibrinolysis of blood were observed in experimental animals exposed to experimental stress. The influence of 129.0 GHz radi ation was studied in animals under conditions of immobilizing stress. No considerable changes in the faulty indi cators of hemostasis and fibrinolysis were observed for 5 min exposure duration. In case of 15 min exposure, partial normalization of indicators characterizing the coagulation cascade and fibrinolysis was observed. The influence of terahertz radiation on the specified frequencies within 30 min caused full normalization of hemoco agulation and fibrinolysis as the studied indicators of a coagulation link of the system of hemostasis and fibri nolysis. Thus, on the basis of the presented data it is pos...