Correction of endotoxemia in patients with nonalcoholic steatohepatitis

Sobirova, G. N.; Karimov, M. M.; Alavi, A.

doi:10.15208/mhsj.2011.180

Cited by 2 publications

(1 citation statement)

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“…In this regard, sorption therapy, which is aimed at detoxification of human body and is achieved via application of high-performance sorbents of medical purpose, becomes significant [1][2][3][4][5]. Medical sorbents are in high demand both for delivery of emergency medical care (acute toxicosis) and for nonoperative therapy of dozens of diseases.…”

Section: Introductionmentioning

confidence: 99%

Physical-Chemical and Pharmacological Research on New Lignin Enterosorbent

Ismailova¹,

Yunuskhodjaeva²,

Ismailova³

et al. 2014

JPP

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Abstract:The technology on obtaining enterosorbent from local feedstock-hydrolyzed lignin of cotton seed hulls named Zerotox was developed. The purpose of this research is to conduct a complex study on its physical-chemical and pharmacological properties. Samples of cotton hydrolyzed lignin based enterosorbent Zerotox were investigated, wood hydrolyzed lignin based enterosorbent Polifepan (Russia) was used as a comparison drug. The technology of new medical enterosorbent Zerotox, based on cotton hydrolyzed lignin, has been developed with its physical-chemical and pharmacological characteristics being researched. Comparative research on adsorbing capacity of sorbent Zerotox (80 mg/g) and its analogue-Polipefan (55 mg/g), which is obtained from wood hydrolyzed lignin, has displayed advantages of the new sorbent. IR-spectroscopy research on lignin sorbent Zerotox has shown presence of oxygen-containing functional groups which determine its high absorbing capacity due to its chemisorption. Atomic-adsorptive method has proved high absorbing capacity of the sorbent towards heavy metals ions. Acute and chronic toxicity and antidiarrheal activity of enterosorbent Zerotox have also been studied.

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Section: Introductionmentioning

confidence: 99%

Physical-Chemical and Pharmacological Research on New Lignin Enterosorbent

Ismailova¹,

Yunuskhodjaeva²,

Ismailova³

et al. 2014

JPP

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Synthesis and Characterization of Novel Nano-,Micro- and Macroporous Lignin Sorbents for Purification of Biological Fluids

Chopabayeva

Mukanov

2015

J. Chem. Eng. Res. Updates.

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Novel nano-, micro- and macroporous ion-exchangers based on hydrolytic lignin of cotton husk have been synthesized by two-step process including o-alkylation of biopolymer with diglycidyl ether of dioxydiphenylpropane and subsequent amination of formed glycidyl derivative. The optimal conditions of synthesis, composition, structure and physical, chemical properties of ion-exchangers were investigated by FTIR, SEM, porosimetry and potentiometric titration method. Textural characteristics of lignin and sorbents were also studied. It has been established that alkaline activated lignin shows an increase of SBET from 17.7 to 20.9 m2/g while modification leads to decrease of SBET more than double (from 14.5 to 9.2-5.2 m2/g) that of an untreared sample. Synthesized ion-exchangers are characterized by approximately identical porous structure and mainly contained a pore size of 10-14 nm. The results show the efficiency of lignin based sorbents for the removal of water and lipid soluble toxic metabolites from blood serum of diabetic retinopathy patients. Considerable detoxication effects of sorbents have potential for prevention and treatment of diabetes.

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Correction of endotoxemia in patients with nonalcoholic steatohepatitis

Cited by 2 publications

References 0 publications

Physical-Chemical and Pharmacological Research on New Lignin Enterosorbent

Physical-Chemical and Pharmacological Research on New Lignin Enterosorbent

Synthesis and Characterization of Novel Nano-,Micro- and Macroporous Lignin Sorbents for Purification of Biological Fluids

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