Correction of glycemic and oxidative stress sensors in streptozotocin induced diabetic rat model: Impact of dose dependent study of n‐butanol solvent fraction of hydro‐methanol extract of banana flower (<i>Musa balbisiana</i>)

Ara, Farhin; Tripathy, Adrija; Ghosh, Pritam; Ghosh, Debidas

doi:10.1111/jfbc.13386

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Diabetes is associated with low genomic expression of anti-oxidant enzymes as well as hyper-activation of lipid peroxidation pathways (Ara et al, 2020) and this is substantiate with our results. After direct exposure to Aloe vera (L.) antioxidant enzyme activities like catalase and SOD were recovered towards the control may be due to the activation of the antioxidant enzymes after they bound to the phytomolecule (s) present in the said extract (Tripathy et al, 2016).…”

Section: Discussionsupporting

confidence: 91%

Anti-Diabetic and Anti-Oxidative Effect of Aloe Vera (L.) Gel: An In- Vitro Approach

Pal,

Roy,

Das

et al. 2021

ijbs

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Medicinal plants are utilized in various formulations to treat a wide range of illnesses, includig diabetes.The present study focused on anti-diabetic and anti-oxidative effect of Aloe vera (L.) in an in-vitro model. Wistar strain albino rats with less than 350 mg/dl of fasting blood glucose level on the 7th day of Streptozotocin (STZ) injection were considered for this study and left for obverting a chronic state of diabetes. On the 29th day of STZ injection, rats were sacrificed and targeted tissues were incubated for 2 hours in an in-vitro medium with 1, 2, and 4 mg of Aloe vera (L.) hydro-ethanol (40:60) extract (AVHE) separately and subjected to evaluation with adopted parameters. Results showed a significant (p˂0.05) recovery in the glucose-6- phosphatase and oxidative stress markers along with GOT and GPT activities in extract-charged groups whereas no significant (p>0.05) changes was noted in hexokinase enzymes activity compared to the unexposed diabetic group. Statistical analysis showed no significant (p>0.05) difference in the recovery level among 1, 2, and 4 mg doses of AVHE. It can be concluded that AVHE has direct ameliorative effect on diabetes and its linked oxidative stress markers.

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Section: Discussionsupporting

confidence: 91%

Anti-Diabetic and Anti-Oxidative Effect of Aloe Vera (L.) Gel: An In- Vitro Approach

Pal,

Roy,

Das

et al. 2021

ijbs

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“…This explanation is compatible with recently published research work by others using another plant. [18,19] Individuals with diabetes had 1.5 and 2 times higher AG and AA activities, respectively. [20] Regularization of the said enzyme activities could be a key therapeutic tool to manage post-prandial hyperglycemia.…”

Section: Resultsmentioning

confidence: 98%

Amelioration of Diabetes Associated Hypo-testicular Co-morbidities in Rat by <i>Aloe vera</i> (L.): Potent Extract Selection Study

Pal,

Lohar,

Mondal

et al. 2024

Int. J. Pharm. Sci. Drug Res.

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The present experiment was conducted to get the most effective extract of Aloe vera (L.) leaf gel for the correction of testicular hypo-function in diabetic rat. A single-time injection (intramuscular) of Streptozotocin at 4 mg/100 g body weight was given for diabetes induction. Treatment with aqueous or ethanol or methanol or hydro-ethanol (40:60) or hydro-methanol (40:60) extract of Aloe vera (L.) was continued for 28 days. Rats were euthanized and sacrificed on 29th day. Fasting blood glucose level, hexokinase activity, androgenic key enzyme activities, and markers of oxidative stress were assessed. Concentration of the sperm per milliliter of epididymal washed fluid, sperm motility, serum testosterone, plasma insulin levels, lipid, and metabolic toxicity sensors were also measured. Significant amelioration (p˂0.05) of the negatively deviated above-mentioned parameters and the disrupted histomorphology of testicles towards vehicle-treated control were noted after uninterrupted 28 days of treatment to diabetic rat with the mentioned extracts of Aloe vera (L.). Highest percentage of recovery in the adopted sensors was noted in the hydro-ethanol extract-treated diabetes group than others. Hydro-ethanol extract of the said plant part is potent among all other extracts for correcting such hypo-function of testicles in diabetes.

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“…Diabetes and obesity are the most critical metabolic and endocrine diseases associated with hyperglycemia and insulin secretion dysfunction (insulin resistance) (Ara et al, 2020; Bermudez‐Pirela et al, 2007). Numerous researches have shown that increasing fatty acids leads to β cells apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Ferula assa‐foetida oleo gum resin ethanolic extract alleviated the pancreatic changes and antioxidant status in streptozotocin‐induced diabetic rats: A biochemical, histopathological, and ultrastructural study

Latifi

Mohammadpour

Hafshejani

et al. 2022

Journal of Food Biochemistry

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The current research examines the effects of administration of 150 and 250 mg/kg body weight/day of ethanolic Ferula assa‐foetida L. oleo gum resin extract (FAE) for 42 days in streptozotocin‐induced diabetes in rats. On day 42, all rats were euthanized; HOMA‐β, HOMA‐IR, and QUICKI levels in pancreas were examined histopathologically and ultrastructurally . Low‐dose FAE (150 mg/kg) treatment resulted in significant improvement in serum glucose, insulin and superoxide dismutase, glutathione, and catalase levels (p < .05). It also improved β‐cell function, restored pancreatic β‐cells, and reduced insulin resistance compared to the diabetic control rats. Necrotic and degenerative alterations in the islets, pyknotic β‐cell nuclei, β‐cell degranulation, reduced islet cellular density, and significant vacuolation were found in the islets of STZ‐diabetic control group ratsby the histomorphological and ultrastructural examination. The pancreatic histomorphology of low dose of FAE‐treated diabetic rats showed remarkable improvements in the islets, such as the β‐cell number and the area of the pancreatic islets. Practical applications The experiment revealed that Ferula assa‐foetida L. may exert antihyperglycemic activity in STZ diabetes via β‐cell regeneration and its high antioxidant capacity. This work elucidates the role of Ferula assa‐foetida L. in diabetes management. Ferula assa‐foetida L. gum extract improved the morphological changes of the diabetic pancreas and stimulated the regeneration of the β cells. The findings demonstrated positive results for the long‐term cure of diabetes. Additionally, this study showed the potential of isolating nutraceuticals for the development of medications.

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Correction of glycemic and oxidative stress sensors in streptozotocin induced diabetic rat model: Impact of dose dependent study of n‐butanol solvent fraction of hydro‐methanol extract of banana flower (Musa balbisiana)

Cited by 6 publications

References 22 publications

Anti-Diabetic and Anti-Oxidative Effect of Aloe Vera (L.) Gel: An In- Vitro Approach

Anti-Diabetic and Anti-Oxidative Effect of Aloe Vera (L.) Gel: An In- Vitro Approach

Amelioration of Diabetes Associated Hypo-testicular Co-morbidities in Rat by <i>Aloe vera</i> (L.): Potent Extract Selection Study

Ferula assa‐foetida oleo gum resin ethanolic extract alleviated the pancreatic changes and antioxidant status in streptozotocin‐induced diabetic rats: A biochemical, histopathological, and ultrastructural study

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