Incidents of male infertility are mushrooming worldwide. Oxidative stress plays a prime role for its onset. Considering this background, the study was designed to focus the direct role of lycopene on cyproterone acetate (CPA) induced testicular hypofunction in rat. Four groups have been considered including the vehicle‐treated control, lycopene‐treated control, CPA‐treated and CPA+ lycopene‐treated groups. Androgenic, antioxidant and toxicity profiles were assessed. Results focused a nonsignificant (p > .05) difference in recovery of testicular Δ5, 3β‐hydroxysteroid dehydrogenase (HSD), 17β‐HSD after direct exposure of lycopene compared to the CPA‐treated group. On other side, lycopene exposure to the testicular tissue of CPA‐treated rat (CPA+ lycopene‐treated) exhibited a significant (p < .05, p < .001) rectification in testicular catalase, superoxide dismutase, peroxidase, glutathione‐S‐transferase activities towards the vehicle‐ and lycopene‐treated control groups. Toxicity profile also showed a significant (p < .001) recovery in CPA‐treated group after direct exposure of lycopene towards the vehicle‐ and lycopene‐treated control groups. So, it can be concluded that direct exposure of lycopene may rectify the CPA‐induced testicular hypofunction either by its free radical‐quenching ability or by stimulating antioxidant enzyme activity without modulating androgenic key enzyme directly.

No abstract

Diabetes mellitus, the very well-known chronic metabolic disorder, is highly prevalent throughout the world. In this condition, high blood glucose level is sustained for a chronic period because of decreased activity of insulin or low level of insulin. Hyperlipidemia, polyuria, polyphagia, polydypsia, oxidative stress, ketosis, hyperglycemia, nephropathy, neuropathy, and cardiovascular disorders are the major complications