Correction: Piras, A.M., et al. Antibacterial, Antibiofilm, and Antiadhesive Properties of Different Quaternized Chitosan Derivatives. Int. J. Mol. Sci. 2019, 20, 6297

Current suture‐based surgical techniques used to repair torn rotator cuff tendons do not result in mechanically competent tendon‐to‐bone attachments, leading to high postoperative failure rates. Although adhesives have been proposed to protect against sutures tearing through tendon during healing, no currently available adhesive meets the clinical needs of adhesive strength, biocompatibility, and promotion of healing. Here, a biocompatible, graded, 3,4‐dihydroxy phenyl chitosan (BGC) bioadhesive designed to meet these needs is presented. Although 3,4‐dihydroxy phenyl chitosan (DP‐chitosan) bioadhesives are biocompatible, their adhesion strength is low; soluble oxidants or cross‐linking agents can be added for higher bonding strength, but this sacrifices biocompatibility. These challenges are overcome by developing a periodate‐modified ion exchange resin‐bead filtration system that oxidizes catechol moieties to quinones and filters off the activating agent and resin. The resulting BGC bioadhesive exhibited sixfold higher strength compared to commercially available tissue adhesives, with strength in the range necessary to improve tendon‐to‐bone repair (≈1MPa, ≈20% of current suture repair strength). The bioadhesive is biocompatible and promoted tenogenesis; cells exposed to the bioadhesive demonstrated enhanced expression of collagen I and the tenogenic marker Scx. Results demonstrated that the bioadhesive has the potential to improve the strength of a tendon‐to‐bone repair and promote healing.

show abstract

Mechanically Competent Chitosan‐Based Bioadhesive for Tendon‐to‐Bone Repair

Fang

Linstadt²,

Genin

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

Functionalized aliphatic polyketones with germicide activity

et al. 2022

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Correction: Piras, A.M., et al. Antibacterial, Antibiofilm, and Antiadhesive Properties of Different Quaternized Chitosan Derivatives. Int. J. Mol. Sci. 2019, 20, 6297

Abstract: The authors wish to make the following corrections to this paper [...]

Cited by 2 publications

References 1 publication

Mechanically Competent Chitosan‐Based Bioadhesive for Tendon‐to‐Bone Repair

Mechanically Competent Chitosan‐Based Bioadhesive for Tendon‐to‐Bone Repair

Functionalized aliphatic polyketones with germicide activity

Contact Info

Product

Resources

About