Correction: Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect

Yan, Shifan; Jiang, Yu; Yu, Ting; Hou, Changmiao; Xiao, Wen; Xu, Jingshi; Huili, Wen; Wang, Jingjing; Li, Shutong; Chen, Fang; Li, Shentang; Liu, Xiehong; Tan, Hao; Zou, Lianhong; Liu, Yanjuan; Zhu, Yimin

doi:10.1186/s13020-023-00760-6

Cited by 2 publications

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the NF-κB/NLRP3 axis is an effective and functional regulator of pyroptosis ( 21 ), the role that AZU1 exerted on the NF-κB/NLRP3 axis was subsequently assessed. Firstly, TNBC cell lines were treated with various concentrations of AZU1 and western blot analysis was utilized to detect the expression of p-65 NF-κB, NLRP3, caspase-1 and ASC.…”

Section: Resultsmentioning

confidence: 99%

Azurocidin 1 inhibits the aberrant proliferation of triple‑negative breast cancer through the regulation of pyroptosis

Lei,

Li,

Xiao

et al. 2023

Oncol Rep

Self Cite

View full text Add to dashboard Cite

Azurocidin 1 (AZU1) is a heparin-binding protein which has been reported to be aberrantly expressed in various tumors, but its definite role in breast cancer (BC) has not been clarified. The aim of the present study was to explore the associations between AZU1 and BC. In the present study, bioinformatics and western blot analyses were applied to detect the expression level of AZU1 in BC tissues. The effect of AZU1 on cell proliferation and apoptosis was analyzed using Cell Counting Kit-8 assay, colony formation assay and flow cytometry. Based on bioinformatics analysis, AZU1 exhibited low expression in tissues and was negatively associated with the survival rate of patients with triple-negative BC (TNBC). Exogenous AZU1 stimuli significantly inhibited the proliferation and colony formation of TNBC cell lines. Furthermore, the data of flow cytometry revealed that exogenous AZU1 stimuli enhanced apoptosis in MDA-231 and BT-549 cells. As pyroptosis is a new type of cell death, the effects AZU1 played on the expression of gasdermin D (GSDMD), a specific biomarker of pyroptosis, were also investigated. The findings of the present study revealed that GSDMD, as well as its upstream regulators [NF-κB, NLR family pyrin domain containing 3 (NLRP3) and caspase-1], were significantly increased in TNBC cell lines when treated with exogenous AZU1, indicating that AZU1 contributed to the inhibition of pyroptosis of TNBC cell lines through the NF-κB/NLRP3/caspase-1 axis. Collectively, it was revealed for the first time, that AZU1 exposure promoted pyroptosis through the modulation of the pNF-κB/NLRP3/caspase-1/GSDMD axis in TNBC in vitro . The findings of the present study unveiled a novel mechanism of AZU1-induced pyroptosis in TNBC, which may aid in developing new strategies for therapeutic interventions in TNBC. breast cancer is the most commone form of cancer in women and is second only to lung cancer in terms of cancer-related mortality.

show abstract

Section: Resultsmentioning

confidence: 99%

Azurocidin 1 inhibits the aberrant proliferation of triple‑negative breast cancer through the regulation of pyroptosis

Lei,

Li,

Xiao

et al. 2023

Oncol Rep

Self Cite

View full text Add to dashboard Cite

show abstract

An alternative asymmetric figure-of-eight single-layer suture technique for bowel anastomosis in an in vitro porcine model

et al. 2022

View full text Add to dashboard Cite

Anastomotic techniques are of vital importance in restoring gastrointestinal continuity after resection. An alternative asymmetric figure-of-eight single-layer suture anastomotic technique was introduced and its effects were evaluated in an in vitro porcine model. Twelve 15-cm grossly healthy small intestine segments from a porcine cadaver were harvested and randomly divided into asymmetric figure-of-eight single-layer suture (figure-of-eight suture) and single-layer interrupted suture technique (interrupted suture) groups (n = 6 in each group). The anastomosed bowel was infused with methylene blue solution to test anastomotic leakage. Anastomosis construction time, leakage, and suture material cost were recorded and analyzed statistically using Fisher's exact test and Student's t-test. One anastomotic leakage occurred (16.67%) in the figure-of-eight suture group, and two (33.33%) in the interrupted suture group (p > 0.9999). The anastomosis construction time was relatively short in the figure-of-eight suture group, but the difference did not reach a statistically significant level between the two groups. The mean number of suture knots and the cost of suture material in the figure-of-eight suture group were significantly decreased in comparison to the interrupted suture group (15.67 ± 3.30 vs. 22.17 ± 2.03, 167.11 ± 35.20 vs. 236.45 ± 21.70 CNY, p < 0.01, respectively). Our results suggested that the alternative asymmetric figure-of-eight suture technique was safe and economic for intestinal anastomosis. An in vivo experiment is required to elucidate the effects of this suture technique on the physiological anastomotic healing process.

show abstract

Correction: Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect

Cited by 2 publications

References 1 publication

Azurocidin 1 inhibits the aberrant proliferation of triple‑negative breast cancer through the regulation of pyroptosis

Azurocidin 1 inhibits the aberrant proliferation of triple‑negative breast cancer through the regulation of pyroptosis

An alternative asymmetric figure-of-eight single-layer suture technique for bowel anastomosis in an in vitro porcine model

Contact Info

Product

Resources

About