Correction: The νSaα Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells

Nguyen, Minh Thu; Kraft, Beatrice; Yu, Wenchao; Demircioglu, Dogan Doruk; Hertlein, Tobias; Burian, Marc; Schmaler, Mathias; Boller, Klaus; Bekeredjian‐Ding, Isabelle; Ohlsen, Knut; Schittek, Birgit; Götz, Friedrich

doi:10.1371/journal.ppat.1005189

Cited by 5 publications

(2 citation statements)

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“…agr is an important regulator of virulence and is also a TCS consisting of the response regulator AgrA and the kinase AgrC. The SaeR/S TCS in essential to the evasion of the innate immune system by reducing reactive oxygen species, aiding survival in the face of host defense peptides, reducing expression of IL-8, and increasing the expression of leukocidins [32, 40, 42, 189, 190]. SaeRS can also regulate the expression of virulence genes including hla [191].…”

Section: Two-component Systemsmentioning

confidence: 99%

Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics

Kane

Carothers

Lee

2018

CDT

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Background Staphylococcus aureus is a major bacterial pathogen capable of causing a range of infections in humans from gastrointestinal disease, skin and soft tissue infections, to severe outcomes such as sepsis. Staphylococcal infections in humans can be frequent and recurring, with treatments becoming less effective due to the growing persistence of antibiotic resistant S. aureus strains. Due to the prevalence of antibiotic resistance, and the current limitations on antibiotic development, an active and highly promising avenue of research has been to develop strategies to specifically inhibit the activity of virulence factors produced S. aureus as an alternative means to treat disease. Objective In this review we specifically highlight several major virulence factors produced by S. aureus for which recent advances in antivirulence approaches may hold promise as an alternative means to treating diseases caused by this pathogen. Strategies to inhibit virulence factors can range from small molecule inhibitors, to antibodies, to mutant and toxoid forms of the virulence proteins. Conclusion The major prevalence of antibiotic resistant strains of S. aureus combined with the lack of new antibiotic discoveries highlight the need for vigorous research into alternative strategies to combat diseases caused by this highly successful pathogen. Current efforts to develop specific antivirulence strategies, vaccine approaches, and alternative therapies for treating severe disease caused by S. aureus have the potential to stem the tide against the limitations that we face in the post-antibiotic era.

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Section: Two-component Systemsmentioning

confidence: 99%

Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics

Kane

Carothers

Lee

2018

CDT

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“…aa) SAUSA300_0410Lpl-1 νSaα specific( Nguyen et al, 2015a,b) Q2FJK3 (266 aa) SAUSA300_0411 Lpl-2 νSaα specific ( Nguyen et al, 2015a,b) Q2FJK2 (266 aa) SAUSA300_0413 Lpl-3 νSaα specific ( Nguyen et al, 2015a,b) Q2FJK1 (256 aa) SAUSA300_0414 Lpl-4 νSaα specific ( Nguyen et al, 2015a,b) Q2FJK0 (263 aa) SAUSA300_0415 Lpl3 Lpl-5 νSaα specific ( Nguyen et al, 2015a,b) Q2FJJ9 (258 aa) SAUSA300_0416 Lpl-6 νSaα specific ( Nguyen et al, 2015a,b) Q2FJJ8 (270 aa) SAUSA300_0417 Lpl-7 νSaα specific ( Nguyen et al, 2015a,b) (continued on next page)…”

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confidence: 99%

Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus

Bartual

Alcorlo

Martínez-Caballero

et al. 2018

International Journal of Medical Microbiology

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Bacterial lipoproteins (Lpp) compose a large family of surface-exposed proteins that are involved in diverse, but critical, cellular functions spanning from fitness to virulence. All of them present a common signature, a sequence motif, known as LipoBox, containing an invariant Cys residue that allows the protein to be covalently bound to the membrane through a thioether linkage. Despite the abundance and relevance of Lpp, there is a scarcity of structural and functional information for this family of proteins. In this review, the updated structural and functional data for Lpp from two Gram-positive pathogenic model organisms, Staphylococcus aureus and Streptococcus pneumoniae is presented. The available structural information offers a glimpse over the Lpp functional mechanisms. Their relevance in bacterial fitness, and also in virulence and host-pathogen interactions, reveals lipoproteins as very attractive targets for designing of novel antimicrobials, and interesting candidates as novel vaccine antigens.

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Prostaglandin E2 accumulation is closely associated with S. aureus-infected bovine endometritis

Liu,

Pei,

Shen

et al. 2024

Cytokine

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Correction: The νSaα Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells

Cited by 5 publications

References 1 publication

Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics

Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics

Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus

Prostaglandin E2 accumulation is closely associated with S. aureus-infected bovine endometritis

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