Correction to: Chemotherapy: a double‑edged sword in cancer treatment

Behranvand, Nafiseh; Nasri, Farzad; Emameh, Reza Zolfaghari; Khani, Pouria; Hosseini, Asieh; Garssen, Johan; Falak, Reza

doi:10.1007/s00262-021-03034-y

Cited by 4 publications

(4 citation statements)

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“…Chemotherapy is widely used for the treatment of various malignant tumors. 1 Chemotherapeutic drugs destroy tumoral cells through different mechanisms, including (a) stimulating internal and external apoptosis pathways via increment of Fas ligand expression and subsequently cytochrome C release; (b) inducing cell cycle arrest via activation of p53 gene following DNA injury and inhibition of kinases; (c) alkylation of DNA and leading to a DNA single-or double-strand break and thereby cell death; (d) interference with microtubules leading to cell growth cessation, and (e) causing direct or indirect DNA damages via generation of reactive oxygen species (ROS). [2][3][4][5][6][7][8][9][10][11] In recent years, high toxicity and multidrug resistance have been recognized as the main obstacle of chemotherapeutic agents in anticancer treatment.…”

Section: Introductionmentioning

confidence: 99%

The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review

et al. 2022

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Although the chemotherapeutic drug, doxorubicin, is commonly used to treat various malignant tumors, its clinical use is restricted because of its toxicity especially cardiotoxicity. The use of curcumin may alleviate some of the doxorubicin‐induced cardiotoxic effects. Especially, using the nano‐formulation of curcumin can overcome the poor bioavailability of curcumin and enhance its physicochemical properties regarding its efficacy. In this study, we systematically reviewed the potential cardioprotective effects of nano‐curcumin against the doxorubicin‐induced cardiotoxicity. A systematic search was accomplished based on Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines for the identification of all relevant articles on “the role of nano‐curcumin on doxorubicin‐induced cardiotoxicity” in the electronic databases of Scopus, PubMed, and Web of Science up to July 2021. One hundred and sixty‐nine articles were screened following a predefined set of inclusion and exclusion criteria. Ten eligible scientific papers were finally included in the present systematic review. The administration of doxorubicin reduced the body and heart weights of mice/rats compared to the control groups. In contrast, the combined treatment of doxorubicin and nano‐curcumin increased the body and heart weights of animals compared with the doxorubicin‐treated groups alone. Furthermore, doxorubicin could significantly induce the biochemical and histological changes in the cardiac tissue; however, coadministration of nano‐curcumin formulation demonstrated a pattern opposite to the doxorubicin‐induced changes. The coadministration of nano‐curcumin alleviates the doxorubicin‐induced cardiotoxicity through various mechanisms including antioxidant, anti‐inflammatory, and antiapoptotic effects. Also, the cardioprotective effect of nano‐curcumin formulation against doxorubicin‐induced cardiotoxicity was higher than free curcumin.

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Section: Introductionmentioning

confidence: 99%

The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review

et al. 2022

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“…In the context of cancer treatment, chemotherapy typically refers to the use of chemical drugs for tumor management. [ 88 ] However, in this review, the term “chemical therapy” is employed to distinguish it from cancer chemotherapy. This distinction encompasses the use of both organic chemical small molecule drugs and inorganic nanoparticles as therapeutic agents.…”

Section: Iron Oxide Nanoparticles‐based Theranostic Nanomedicine Util...mentioning

confidence: 99%

Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles

Wang,

He,

Mao

et al. 2024

Advanced Science

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Atherosclerosis, a multifaceted chronic inflammatory disease, has a profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include the delayed detection of advanced stages, the intricate assessment of plaque stability, and the absence of efficacious therapeutic strategies. Nanotheranostic based on nanotechnology offers a novel paradigm for addressing these challenges by amalgamating advanced imaging capabilities with targeted therapeutic interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates for theranostic applications in atherosclerosis due to their magnetic resonance imaging capability and biosafety. This review delineates the current state and prospects of iron oxide nanoparticle‐based nanotheranostics in the realm of atherosclerosis, including pivotal aspects of atherosclerosis development, the pertinent targeting strategies involved in disease pathogenesis, and the diagnostic and therapeutic roles of iron oxide nanoparticles. Furthermore, this review provides a comprehensive overview of theranostic nanomedicine approaches employing iron oxide nanoparticles, encompassing chemical therapy, physical stimulation therapy, and biological therapy. Finally, this review proposes and discusses the challenges and prospects associated with translating these innovative strategies into clinically viable anti‐atherosclerosis interventions. In conclusion, this review offers new insights into the future of atherosclerosis theranostic, showcasing the remarkable potential of iron oxide‐based nanoparticles as versatile tools in the battle against atherosclerosis.

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“…Aggressive cancers remain the leading cause of death around the world, accounting for 9.96 million deaths in 2020. 1 Nowadays, multiple treatments including surgery, 2,3 chemotherapy, 4,5 radiotherapy 6,7 and immunotherapy 8,9 have been applied. Among them, surgery is regarded as the most common strategy in the clinical treatment of the majority of tumors.…”

Section: Introductionmentioning

confidence: 99%