Correction to Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials

Mott, Andrew; Bradley, Thomas Gerard; Wright, Kath; Cockayne, Elizabeth Sarah; Shearer, Martin J.; Adamson, Joy; Lanham-New, Susan A; Torgerson, David

doi:10.1007/s00198-020-05586-8

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…Vitamin K has, apart from its effect on blood coagulation, also an effect on bone mineralization and bone formation. However, in a meta-analysis, no effect of vitamin K supplementation was found on BMD and on fracture rate [ 47 ]. It is important to realize that vitamin K supplementation might interfere with blood coagulation.…”

Section: Resultsmentioning

confidence: 99%

The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena

van den Bergh,

Geusens,

Appelman-Dijkstra

et al. 2024

Arch Osteoporos

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Background In 2018, a grant was provided for an evidence-based guideline on osteoporosis and fracture prevention based on 10 clinically relevant questions. Methods A multidisciplinary working group was formed with delegates from Dutch scientific and professional societies, including representatives from the patient’s organization and the Dutch Institute for Medical Knowledge. The purpose was to obtain a broad consensus among all participating societies to facilitate the implementation of the updated guideline. Results Novel recommendations in our guideline are as follows: - In patients with an indication for DXA of the lumbar spine and hips, there is also an indication for VFA. - Directly starting with anabolic drugs (teriparatide or romosozumab) in patients with a very high fracture risk; - Directly starting with zoledronic acid in patients 75 years and over with a hip fracture (independent of DXA); - Directly starting with parenteral drugs (denosumab, teriparatide, zoledronic acid) in glucocorticoid-induced osteoporosis with very high fracture risk; - A lifelong fracture risk management, including lifestyle, is indicated from the start of the first treatment. Conclusion In our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 “relatively new statements” that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implementation.

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Section: Resultsmentioning

confidence: 99%

The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena

van den Bergh,

Geusens,

Appelman-Dijkstra

et al. 2024

Arch Osteoporos

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show abstract

“…bone mineral density and fractures). Most included studies typically adopted large doses of Vitamin K2 in the form of pharmaceutical MK4 (1.5 mg up to 45 mg) or MK7 (up to 375 µg) 5,6 and reported no benefits of Vitamin K supplements for bone mineral density and vertebral fractures. Evidence for a reduction in clinical fractures in post-menopausal or osteoporotic patients were reported.…”

Section: Discussionmentioning

confidence: 99%

“…1 Although best known for its role in blood coagulation, epidemiological investigation and clinical trials suggest that Vitamin K intake is important for skeletal health. [2][3][4][5][6] Basic studies of Vitamin K have supported the clinical data by identifying a critical role in the γ-carboxylation of the Vitamin K dependant bone proteins, including osteocalcin (OC). 7 Specifically, OC is produced by osteoblasts and is believed to improve bone toughness, 7 which is essential for preventing fractures.…”

Section: Introductionmentioning

confidence: 99%

Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk: the Perth longitudinal study of ageing women

et al. 2022

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“…Finally, a 2019 meta-analysis by Mott carried out on 36 studies with a total of 11,112 participants who were followed for a follow-up ranging from 6 to 48 months stated that in osteoporotic or postmenopausal patients, fractures were lower in those who had vitamin K supplementation than in the control (2.24% and 3.06%, respectively, with OR of 0.72) but not at the level of vertebral fractures [ 133 ].…”

Section: Discussionmentioning

confidence: 99%

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

et al. 2021

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Bone is a nutritionally modulated tissue. Given this background, aim of this review is to evaluate the latest data regarding ideal dietary approach in order to reduce bone mineral density loss and to construct a food pyramid that allows osteopenia/osteoporosis patients to easily figure out what to eat. The pyramid shows that carbohydrates should be consumed every day (3 portions of whole grains), together with fruits and vegetables (5 portions; orange-colored fruits and vegetables and green leafy vegetables are to be preferred), light yogurt (125 mL), skim milk (200 mL,) extra virgin olive oil (almost 20 mg/day), and calcium water (almost 1 l/day); weekly portions should include fish (4 portions), white meat (3 portions), legumes (2 portions), eggs (2 portions), cheeses (2 portions), and red or processed meats (once/week). At the top of the pyramid, there are two pennants: one green means that osteopenia/osteoporosis subjects need some personalized supplementation (if daily requirements cannot be satisfied through diet, calcium, vitamin D, boron, omega 3, and isoflavones supplementation could be an effective strategy with a great benefit/cost ratio), and one red means that there are some foods that are banned (salt, sugar, inorganic phosphate additives). Finally, three to four times per week of 30–40 min of aerobic and resistance exercises must be performed.

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Correction to Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials

Abstract: Mean difference in Bone Mineral Density of the Radius at 24 months-Figure 5, part 3 Only two studies had data available for this, YOPS and Cheung et al. Taking the results only from Cheung et al. [6], the estimate would be 0.00 (95%CI − 0.85 to 0.85).

Cited by 9 publications

References 6 publications

The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena

The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena

Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk: the Perth longitudinal study of ageing women

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

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